Oscillatory cortical network involved in auditory verbal hallucinations in schizophrenia.

<h4>Background</h4>Auditory verbal hallucinations (AVH), a prominent symptom of schizophrenia, are often highly distressing for patients. Better understanding of the pathogenesis of hallucinations could increase therapeutic options. Magnetoencephalography (MEG) provides direct measures o...

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Autores principales:	Remko van Lutterveld, Arjan Hillebrand, Kelly M J Diederen, Kirstin Daalman, René S Kahn, Cornelis J Stam, Iris E C Sommer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/74a9a232b9c34fd0a1f3138f02ee2869
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spelling	oai:doaj.org-article:74a9a232b9c34fd0a1f3138f02ee28692021-11-18T07:11:35ZOscillatory cortical network involved in auditory verbal hallucinations in schizophrenia.1932-620310.1371/journal.pone.0041149https://doaj.org/article/74a9a232b9c34fd0a1f3138f02ee28692012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22844436/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Auditory verbal hallucinations (AVH), a prominent symptom of schizophrenia, are often highly distressing for patients. Better understanding of the pathogenesis of hallucinations could increase therapeutic options. Magnetoencephalography (MEG) provides direct measures of neuronal activity and has an excellent temporal resolution, offering a unique opportunity to study AVH pathophysiology.<h4>Methods</h4>Twelve patients (10 paranoid schizophrenia, 2 psychosis not otherwise specified) indicated the presence of AVH by button-press while lying in a MEG scanner. As a control condition, patients performed a self-paced button-press task. AVH-state and non-AVH state were contrasted in a region-of-interest (ROI) approach. In addition, the two seconds before AVH onset were contrasted with the two seconds after AVH onset to elucidate a possible triggering mechanism.<h4>Results</h4>AVH correlated with a decrease in beta-band power in the left temporal cortex. A decrease in alpha-band power was observed in the right inferior frontal gyrus. AVH onset was related to a decrease in theta-band power in the right hippocampus.<h4>Conclusions</h4>These results suggest that AVH are triggered by a short aberration in the theta band in a memory-related structure, followed by activity in language areas accompanying the experience of AVH itself.Remko van LutterveldArjan HillebrandKelly M J DiederenKirstin DaalmanRené S KahnCornelis J StamIris E C SommerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e41149 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Remko van Lutterveld Arjan Hillebrand Kelly M J Diederen Kirstin Daalman René S Kahn Cornelis J Stam Iris E C Sommer Oscillatory cortical network involved in auditory verbal hallucinations in schizophrenia.
description	<h4>Background</h4>Auditory verbal hallucinations (AVH), a prominent symptom of schizophrenia, are often highly distressing for patients. Better understanding of the pathogenesis of hallucinations could increase therapeutic options. Magnetoencephalography (MEG) provides direct measures of neuronal activity and has an excellent temporal resolution, offering a unique opportunity to study AVH pathophysiology.<h4>Methods</h4>Twelve patients (10 paranoid schizophrenia, 2 psychosis not otherwise specified) indicated the presence of AVH by button-press while lying in a MEG scanner. As a control condition, patients performed a self-paced button-press task. AVH-state and non-AVH state were contrasted in a region-of-interest (ROI) approach. In addition, the two seconds before AVH onset were contrasted with the two seconds after AVH onset to elucidate a possible triggering mechanism.<h4>Results</h4>AVH correlated with a decrease in beta-band power in the left temporal cortex. A decrease in alpha-band power was observed in the right inferior frontal gyrus. AVH onset was related to a decrease in theta-band power in the right hippocampus.<h4>Conclusions</h4>These results suggest that AVH are triggered by a short aberration in the theta band in a memory-related structure, followed by activity in language areas accompanying the experience of AVH itself.
format	article
author	Remko van Lutterveld Arjan Hillebrand Kelly M J Diederen Kirstin Daalman René S Kahn Cornelis J Stam Iris E C Sommer
author_facet	Remko van Lutterveld Arjan Hillebrand Kelly M J Diederen Kirstin Daalman René S Kahn Cornelis J Stam Iris E C Sommer
author_sort	Remko van Lutterveld
title	Oscillatory cortical network involved in auditory verbal hallucinations in schizophrenia.
title_short	Oscillatory cortical network involved in auditory verbal hallucinations in schizophrenia.
title_full	Oscillatory cortical network involved in auditory verbal hallucinations in schizophrenia.
title_fullStr	Oscillatory cortical network involved in auditory verbal hallucinations in schizophrenia.
title_full_unstemmed	Oscillatory cortical network involved in auditory verbal hallucinations in schizophrenia.
title_sort	oscillatory cortical network involved in auditory verbal hallucinations in schizophrenia.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/74a9a232b9c34fd0a1f3138f02ee2869
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Oscillatory cortical network involved in auditory verbal hallucinations in schizophrenia.

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