Subjective Cognitive Complaints in Newly-Diagnosed Parkinson’s Disease With and Without Mild Cognitive Impairment

Background: Subjective cognitive complaints (SCCs) and mild cognitive impairment (MCI) are common among patients with Parkinson’s disease (PD). However, the relationship between SCCs and MCI is not well understood. Herein, we aimed to investigate whether there are any differences in the prevalence a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chenxi Pan, Jingru Ren, Ping Hua, Lei Yan, Miao Yu, Yajie Wang, Gaiyan Zhou, Ronggui Zhang, Jiu Chen, Weiguo Liu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Parkinson’s disease subjective cognitive complaints mild cognitive impairment non-motor symptoms attention/working memory Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/74aa83f93b564fa3adf2d24cf2551c26
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:74aa83f93b564fa3adf2d24cf2551c26
record_format	dspace
spelling	oai:doaj.org-article:74aa83f93b564fa3adf2d24cf2551c262021-11-30T17:14:53ZSubjective Cognitive Complaints in Newly-Diagnosed Parkinson’s Disease With and Without Mild Cognitive Impairment1662-453X10.3389/fnins.2021.761817https://doaj.org/article/74aa83f93b564fa3adf2d24cf2551c262021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.761817/fullhttps://doaj.org/toc/1662-453XBackground: Subjective cognitive complaints (SCCs) and mild cognitive impairment (MCI) are common among patients with Parkinson’s disease (PD). However, the relationship between SCCs and MCI is not well understood. Herein, we aimed to investigate whether there are any differences in the prevalence and risk factors of SCCs between early PD patients with and without MCI.Methods: Overall, 108 newly diagnosed, untreated PD patients underwent comprehensive neuropsychological assessments. PD patients with mild cognitive impairment (PD-MCI) were diagnosed according to the MCI level II criteria. Furthermore, SCCs were measured with the Cognitive Complaints Interview (CCI). Logistic regression analysis, after adjusting for confounding variable, was performed in order to investigate risk factors of SCCs in PD-MCI patients and PD patients with normal cognition (PD-NC).Results: Furthermore, 42 (42.3%) participants reported SCCs and 53 (53.5%) participants were diagnosed with PD-MCI. The prevalence of SCCs in PD-MCI and PD-NC participants was 30.3% and 12.1%, respectively. Logistic regression analyses revealed that the presence of SCCs in PD-MCI group was significantly associated with Non-Motor Symptoms Questionnaire (NMSQ) score (OR = 1.340, 95%CI = 1.115−1.610, p = 0.002), while the presence of SCCs in PD-NC group was significantly associated with time of Stroop Color-Word Test card C (OR = 1.050, 95%CI = 1.009−1.119, p = 0.016).Conclusion: SCCs are frequent among patients with early PD. The prevalence and risk factor of SCCs are distinct in PD with and without MCI. These findings suggest that SCCs in early PD with different cognitive status appear to have different pathogenicity.Chenxi PanJingru RenPing HuaLei YanMiao YuYajie WangGaiyan ZhouRonggui ZhangJiu ChenJiu ChenWeiguo LiuFrontiers Media S.A.articleParkinson’s diseasesubjective cognitive complaintsmild cognitive impairmentnon-motor symptomsattention/working memoryNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Parkinson’s disease subjective cognitive complaints mild cognitive impairment non-motor symptoms attention/working memory Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Parkinson’s disease subjective cognitive complaints mild cognitive impairment non-motor symptoms attention/working memory Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Chenxi Pan Jingru Ren Ping Hua Lei Yan Miao Yu Yajie Wang Gaiyan Zhou Ronggui Zhang Jiu Chen Jiu Chen Weiguo Liu Subjective Cognitive Complaints in Newly-Diagnosed Parkinson’s Disease With and Without Mild Cognitive Impairment
description	Background: Subjective cognitive complaints (SCCs) and mild cognitive impairment (MCI) are common among patients with Parkinson’s disease (PD). However, the relationship between SCCs and MCI is not well understood. Herein, we aimed to investigate whether there are any differences in the prevalence and risk factors of SCCs between early PD patients with and without MCI.Methods: Overall, 108 newly diagnosed, untreated PD patients underwent comprehensive neuropsychological assessments. PD patients with mild cognitive impairment (PD-MCI) were diagnosed according to the MCI level II criteria. Furthermore, SCCs were measured with the Cognitive Complaints Interview (CCI). Logistic regression analysis, after adjusting for confounding variable, was performed in order to investigate risk factors of SCCs in PD-MCI patients and PD patients with normal cognition (PD-NC).Results: Furthermore, 42 (42.3%) participants reported SCCs and 53 (53.5%) participants were diagnosed with PD-MCI. The prevalence of SCCs in PD-MCI and PD-NC participants was 30.3% and 12.1%, respectively. Logistic regression analyses revealed that the presence of SCCs in PD-MCI group was significantly associated with Non-Motor Symptoms Questionnaire (NMSQ) score (OR = 1.340, 95%CI = 1.115−1.610, p = 0.002), while the presence of SCCs in PD-NC group was significantly associated with time of Stroop Color-Word Test card C (OR = 1.050, 95%CI = 1.009−1.119, p = 0.016).Conclusion: SCCs are frequent among patients with early PD. The prevalence and risk factor of SCCs are distinct in PD with and without MCI. These findings suggest that SCCs in early PD with different cognitive status appear to have different pathogenicity.
format	article
author	Chenxi Pan Jingru Ren Ping Hua Lei Yan Miao Yu Yajie Wang Gaiyan Zhou Ronggui Zhang Jiu Chen Jiu Chen Weiguo Liu
author_facet	Chenxi Pan Jingru Ren Ping Hua Lei Yan Miao Yu Yajie Wang Gaiyan Zhou Ronggui Zhang Jiu Chen Jiu Chen Weiguo Liu
author_sort	Chenxi Pan
title	Subjective Cognitive Complaints in Newly-Diagnosed Parkinson’s Disease With and Without Mild Cognitive Impairment
title_short	Subjective Cognitive Complaints in Newly-Diagnosed Parkinson’s Disease With and Without Mild Cognitive Impairment
title_full	Subjective Cognitive Complaints in Newly-Diagnosed Parkinson’s Disease With and Without Mild Cognitive Impairment
title_fullStr	Subjective Cognitive Complaints in Newly-Diagnosed Parkinson’s Disease With and Without Mild Cognitive Impairment
title_full_unstemmed	Subjective Cognitive Complaints in Newly-Diagnosed Parkinson’s Disease With and Without Mild Cognitive Impairment
title_sort	subjective cognitive complaints in newly-diagnosed parkinson’s disease with and without mild cognitive impairment
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/74aa83f93b564fa3adf2d24cf2551c26
work_keys_str_mv	AT chenxipan subjectivecognitivecomplaintsinnewlydiagnosedparkinsonsdiseasewithandwithoutmildcognitiveimpairment AT jingruren subjectivecognitivecomplaintsinnewlydiagnosedparkinsonsdiseasewithandwithoutmildcognitiveimpairment AT pinghua subjectivecognitivecomplaintsinnewlydiagnosedparkinsonsdiseasewithandwithoutmildcognitiveimpairment AT leiyan subjectivecognitivecomplaintsinnewlydiagnosedparkinsonsdiseasewithandwithoutmildcognitiveimpairment AT miaoyu subjectivecognitivecomplaintsinnewlydiagnosedparkinsonsdiseasewithandwithoutmildcognitiveimpairment AT yajiewang subjectivecognitivecomplaintsinnewlydiagnosedparkinsonsdiseasewithandwithoutmildcognitiveimpairment AT gaiyanzhou subjectivecognitivecomplaintsinnewlydiagnosedparkinsonsdiseasewithandwithoutmildcognitiveimpairment AT rongguizhang subjectivecognitivecomplaintsinnewlydiagnosedparkinsonsdiseasewithandwithoutmildcognitiveimpairment AT jiuchen subjectivecognitivecomplaintsinnewlydiagnosedparkinsonsdiseasewithandwithoutmildcognitiveimpairment AT jiuchen subjectivecognitivecomplaintsinnewlydiagnosedparkinsonsdiseasewithandwithoutmildcognitiveimpairment AT weiguoliu subjectivecognitivecomplaintsinnewlydiagnosedparkinsonsdiseasewithandwithoutmildcognitiveimpairment
_version_	1718406387184173056

Subjective Cognitive Complaints in Newly-Diagnosed Parkinson’s Disease With and Without Mild Cognitive Impairment

Ejemplares similares