Improvement in the Survival of Esophageal Cancer Patients at Cancer Institute of Iran after Implementation of the Neo-adjuvant Chemo-radiation: Retrospective Cohort Study

Background: Iran is a high-risk area with a poor prognosis for esophageal cancer. We conducted the present study to evaluate the survival rate of esophageal cancer after the introduction of neo-adjuvant chemo-radiation at the Cancer Institute of Iran. Method: We performed a retrospective cohort stud...

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Autores principales:	Saeed Nemati, Maryam Hadji, Parissa Seifi, Mohammad Shirkhoda, Mojtaba Vand Rajabpour, Nazanin Rajaei, Mahdi Aghili, Mohammad Ali Mohagheghi, Kazem Zendehdel
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2021
Materias:	esophagus neoplasms staging chemoradiation survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/74af21f5ac47452788b3e1bb09bb1f26
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spelling	oai:doaj.org-article:74af21f5ac47452788b3e1bb09bb1f262021-11-29T10:40:47ZImprovement in the Survival of Esophageal Cancer Patients at Cancer Institute of Iran after Implementation of the Neo-adjuvant Chemo-radiation: Retrospective Cohort Study2008-67092008-668710.30476/mejc.2021.84185.1205https://doaj.org/article/74af21f5ac47452788b3e1bb09bb1f262021-10-01T00:00:00Zhttps://mejc.sums.ac.ir/article_47380_8e68ec5598d55bd06ce7963ad86e7f39.pdfhttps://doaj.org/toc/2008-6709https://doaj.org/toc/2008-6687Background: Iran is a high-risk area with a poor prognosis for esophageal cancer. We conducted the present study to evaluate the survival rate of esophageal cancer after the introduction of neo-adjuvant chemo-radiation at the Cancer Institute of Iran. Method: We performed a retrospective cohort study and abstracted the data of 421 patients who referred to the Cancer Institute of Iran between 2007 and 2011. Life table and Kaplan-Meier approaches were applied to estimate 1-, 3-, and 5-year survival rates and corresponding 95% confidence intervals (CI). Multiple Cox regression model was recruited for investigating the association between 5-year survival rate and prognostic factors. Results: We found that 1-, 3-, and 5-year survival rates were 66.7%, 28.2, and 20.9%, respectively. The hazard ratio (HR) was significantly higher among the patients who has received definitive chemo-radiation therapy (Hazard ratio (HR) = 2.2, 95% confidence interval (CI): 1.1, 4.2), surgery (HR= 2.0 95% CI: 1.0, 3.7), and palliative care (HR= 4.2, 95% CI: 2.1, 1.8) compared with those who received neo-adjuvant chemo-radiation and surgery. We also found that the 5-year survival rate was doubled in the current study conducted between 2007 and 2011 (20.9%) compared with the previous one conducted between 1997 and 2006 (10.0%). Additionally, a considerable improvement was observed in 1- and 3-year survival rate of esophageal cancer at the Cancer Institute of Iran. Conclusion: Following the administration of neo-adjuvant chemo-radiation therapy, the prognosis of esophageal cancer has improved significantly at the Cancer Institute of Iran during the last decade. More data from other cancer centers and provinces of Iran are required.Saeed NematiMaryam HadjiParissa SeifiMohammad ShirkhodaMojtaba Vand RajabpourNazanin RajaeiMahdi AghiliMohammad Ali MohagheghiKazem ZendehdelShiraz University of Medical SciencesarticleesophagusneoplasmsstagingchemoradiationsurvivalNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENMiddle East Journal of Cancer , Vol 12, Iss 4, Pp 535-542 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	esophagus neoplasms staging chemoradiation survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	esophagus neoplasms staging chemoradiation survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Saeed Nemati Maryam Hadji Parissa Seifi Mohammad Shirkhoda Mojtaba Vand Rajabpour Nazanin Rajaei Mahdi Aghili Mohammad Ali Mohagheghi Kazem Zendehdel Improvement in the Survival of Esophageal Cancer Patients at Cancer Institute of Iran after Implementation of the Neo-adjuvant Chemo-radiation: Retrospective Cohort Study
description	Background: Iran is a high-risk area with a poor prognosis for esophageal cancer. We conducted the present study to evaluate the survival rate of esophageal cancer after the introduction of neo-adjuvant chemo-radiation at the Cancer Institute of Iran. Method: We performed a retrospective cohort study and abstracted the data of 421 patients who referred to the Cancer Institute of Iran between 2007 and 2011. Life table and Kaplan-Meier approaches were applied to estimate 1-, 3-, and 5-year survival rates and corresponding 95% confidence intervals (CI). Multiple Cox regression model was recruited for investigating the association between 5-year survival rate and prognostic factors. Results: We found that 1-, 3-, and 5-year survival rates were 66.7%, 28.2, and 20.9%, respectively. The hazard ratio (HR) was significantly higher among the patients who has received definitive chemo-radiation therapy (Hazard ratio (HR) = 2.2, 95% confidence interval (CI): 1.1, 4.2), surgery (HR= 2.0 95% CI: 1.0, 3.7), and palliative care (HR= 4.2, 95% CI: 2.1, 1.8) compared with those who received neo-adjuvant chemo-radiation and surgery. We also found that the 5-year survival rate was doubled in the current study conducted between 2007 and 2011 (20.9%) compared with the previous one conducted between 1997 and 2006 (10.0%). Additionally, a considerable improvement was observed in 1- and 3-year survival rate of esophageal cancer at the Cancer Institute of Iran. Conclusion: Following the administration of neo-adjuvant chemo-radiation therapy, the prognosis of esophageal cancer has improved significantly at the Cancer Institute of Iran during the last decade. More data from other cancer centers and provinces of Iran are required.
format	article
author	Saeed Nemati Maryam Hadji Parissa Seifi Mohammad Shirkhoda Mojtaba Vand Rajabpour Nazanin Rajaei Mahdi Aghili Mohammad Ali Mohagheghi Kazem Zendehdel
author_facet	Saeed Nemati Maryam Hadji Parissa Seifi Mohammad Shirkhoda Mojtaba Vand Rajabpour Nazanin Rajaei Mahdi Aghili Mohammad Ali Mohagheghi Kazem Zendehdel
author_sort	Saeed Nemati
title	Improvement in the Survival of Esophageal Cancer Patients at Cancer Institute of Iran after Implementation of the Neo-adjuvant Chemo-radiation: Retrospective Cohort Study
title_short	Improvement in the Survival of Esophageal Cancer Patients at Cancer Institute of Iran after Implementation of the Neo-adjuvant Chemo-radiation: Retrospective Cohort Study
title_full	Improvement in the Survival of Esophageal Cancer Patients at Cancer Institute of Iran after Implementation of the Neo-adjuvant Chemo-radiation: Retrospective Cohort Study
title_fullStr	Improvement in the Survival of Esophageal Cancer Patients at Cancer Institute of Iran after Implementation of the Neo-adjuvant Chemo-radiation: Retrospective Cohort Study
title_full_unstemmed	Improvement in the Survival of Esophageal Cancer Patients at Cancer Institute of Iran after Implementation of the Neo-adjuvant Chemo-radiation: Retrospective Cohort Study
title_sort	improvement in the survival of esophageal cancer patients at cancer institute of iran after implementation of the neo-adjuvant chemo-radiation: retrospective cohort study
publisher	Shiraz University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/74af21f5ac47452788b3e1bb09bb1f26
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Improvement in the Survival of Esophageal Cancer Patients at Cancer Institute of Iran after Implementation of the Neo-adjuvant Chemo-radiation: Retrospective Cohort Study

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