Mesoporous silica nanoparticles functionalized with folic acid for targeted release Cis-Pt to glioblastoma cells

This work reports the preparation, characterization, and a drug release study of mesoporous silica nanoparticles (MNPSiO2) functionalized with folic acid (FA) and loaded with Cis-Pt as a targeted release system to kill glioblastoma cancer cells. The MNPSiO2 were synthesized by the Stöber method usin...

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Autores principales:	Ortiz-Islas Emma, Sosa-Arróniz Anahí, Manríquez-Ramírez Ma Elena, Rodríguez-Pérez C. Ekaterina, Tzompantzi Francisco, Padilla Juan Manuel
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	silica nanoparticles drug release vehicle brain cancer cells cell uptake Technology T Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/74b2c97083de4923b476a0f16a23c94d
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spelling	oai:doaj.org-article:74b2c97083de4923b476a0f16a23c94d2021-12-05T14:11:02ZMesoporous silica nanoparticles functionalized with folic acid for targeted release Cis-Pt to glioblastoma cells1605-812710.1515/rams-2021-0009https://doaj.org/article/74b2c97083de4923b476a0f16a23c94d2021-01-01T00:00:00Zhttps://doi.org/10.1515/rams-2021-0009https://doaj.org/toc/1605-8127This work reports the preparation, characterization, and a drug release study of mesoporous silica nanoparticles (MNPSiO2) functionalized with folic acid (FA) and loaded with Cis-Pt as a targeted release system to kill glioblastoma cancer cells. The MNPSiO2 were synthesized by the Stöber method using hexadecyltrimethylammonium bromide as the templating agent, which was finally removed by calcination at 550°C. The folic acid was chemically anchored to the silica nanoparticles surface by a carbodiimide reaction. Several physicochemical techniques were used for the MNPSiO2 characterization, and a triplicate in vitro Cis-Pt release test was carried out. The release Cis-Pt experimental values were fitted to different theoretical models to find the Cis-Pt release mechanism. The cytotoxicity evaluation of the MNPSiO2 was performed using LN 18 cells (human GBM cells). Homogeneous and well-defined nanoparticles with well-distributed and homogeneous porosity were obtained. The spectroscopic results show the proper functionalization of the mesoporous nanoparticles; besides, MNPSiO2 showed high surface area and large pore size. High correlation coefficients were obtained. Though the best fitted was the Korsmeyer-Peppas kinetic model, the Higuchi model adjusted better to the results obtained for our system. The MNPSiO2-FA were highly biocompatible, and they increased the cytotoxic effect of Cis-Pt loaded in them.Ortiz-Islas EmmaSosa-Arróniz AnahíManríquez-Ramírez Ma ElenaRodríguez-Pérez C. EkaterinaTzompantzi FranciscoPadilla Juan ManuelDe Gruyterarticlesilica nanoparticlesdrug release vehiclebrain cancer cellscell uptakeTechnologyTChemical technologyTP1-1185ENReviews on Advanced Materials Science, Vol 60, Iss 1, Pp 25-37 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	silica nanoparticles drug release vehicle brain cancer cells cell uptake Technology T Chemical technology TP1-1185
spellingShingle	silica nanoparticles drug release vehicle brain cancer cells cell uptake Technology T Chemical technology TP1-1185 Ortiz-Islas Emma Sosa-Arróniz Anahí Manríquez-Ramírez Ma Elena Rodríguez-Pérez C. Ekaterina Tzompantzi Francisco Padilla Juan Manuel Mesoporous silica nanoparticles functionalized with folic acid for targeted release Cis-Pt to glioblastoma cells
description	This work reports the preparation, characterization, and a drug release study of mesoporous silica nanoparticles (MNPSiO2) functionalized with folic acid (FA) and loaded with Cis-Pt as a targeted release system to kill glioblastoma cancer cells. The MNPSiO2 were synthesized by the Stöber method using hexadecyltrimethylammonium bromide as the templating agent, which was finally removed by calcination at 550°C. The folic acid was chemically anchored to the silica nanoparticles surface by a carbodiimide reaction. Several physicochemical techniques were used for the MNPSiO2 characterization, and a triplicate in vitro Cis-Pt release test was carried out. The release Cis-Pt experimental values were fitted to different theoretical models to find the Cis-Pt release mechanism. The cytotoxicity evaluation of the MNPSiO2 was performed using LN 18 cells (human GBM cells). Homogeneous and well-defined nanoparticles with well-distributed and homogeneous porosity were obtained. The spectroscopic results show the proper functionalization of the mesoporous nanoparticles; besides, MNPSiO2 showed high surface area and large pore size. High correlation coefficients were obtained. Though the best fitted was the Korsmeyer-Peppas kinetic model, the Higuchi model adjusted better to the results obtained for our system. The MNPSiO2-FA were highly biocompatible, and they increased the cytotoxic effect of Cis-Pt loaded in them.
format	article
author	Ortiz-Islas Emma Sosa-Arróniz Anahí Manríquez-Ramírez Ma Elena Rodríguez-Pérez C. Ekaterina Tzompantzi Francisco Padilla Juan Manuel
author_facet	Ortiz-Islas Emma Sosa-Arróniz Anahí Manríquez-Ramírez Ma Elena Rodríguez-Pérez C. Ekaterina Tzompantzi Francisco Padilla Juan Manuel
author_sort	Ortiz-Islas Emma
title	Mesoporous silica nanoparticles functionalized with folic acid for targeted release Cis-Pt to glioblastoma cells
title_short	Mesoporous silica nanoparticles functionalized with folic acid for targeted release Cis-Pt to glioblastoma cells
title_full	Mesoporous silica nanoparticles functionalized with folic acid for targeted release Cis-Pt to glioblastoma cells
title_fullStr	Mesoporous silica nanoparticles functionalized with folic acid for targeted release Cis-Pt to glioblastoma cells
title_full_unstemmed	Mesoporous silica nanoparticles functionalized with folic acid for targeted release Cis-Pt to glioblastoma cells
title_sort	mesoporous silica nanoparticles functionalized with folic acid for targeted release cis-pt to glioblastoma cells
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/74b2c97083de4923b476a0f16a23c94d
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Mesoporous silica nanoparticles functionalized with folic acid for targeted release Cis-Pt to glioblastoma cells

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