RhoGTPase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitment

Countering Bone Loss in Space A chemical element naturally found for instance in seafood or grains, could counter bone loss from long-term spaceflight. Alain Guignandon and colleagues from the Université de Lyon à St-Etienne in France exposed multipotent embryonic fibroblasts to microgravity conditi...

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Autores principales:	Fiona Louis, Wafa Bouleftour, Aline Rattner, Marie-Thérèse Linossier, Laurence Vico, Alain Guignandon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Biotechnology TP248.13-248.65 Physiology QP1-981
Acceso en línea:	https://doaj.org/article/74b4487b9a43410ab4bb7e9d1adb01a1
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id	oai:doaj.org-article:74b4487b9a43410ab4bb7e9d1adb01a1
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spelling	oai:doaj.org-article:74b4487b9a43410ab4bb7e9d1adb01a12021-12-02T15:18:48ZRhoGTPase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitment10.1038/s41526-016-0004-62373-8065https://doaj.org/article/74b4487b9a43410ab4bb7e9d1adb01a12017-01-01T00:00:00Zhttps://doi.org/10.1038/s41526-016-0004-6https://doaj.org/toc/2373-8065Countering Bone Loss in Space A chemical element naturally found for instance in seafood or grains, could counter bone loss from long-term spaceflight. Alain Guignandon and colleagues from the Université de Lyon à St-Etienne in France exposed multipotent embryonic fibroblasts to microgravity conditions similar to those found in space. They found the balance shifted in these stem cells from differentiating to bone-forming cells (osteoblasts) to differentiating to fatty-tissue forming cells (adipocytes). When the cells were treated with strontium, the shift toward osteoblastogenesis was regained. Strontium achieves this by sustaining the activity of two proteins that play a role in bone development but are suppressed in space. Strontium’s effect on the proteins could happen via release of vascular endothelial growth factor, which, under normal gravity conditions, plays a role in committing the cell to differentiation into osteoblasts rather than adipoyctes.Fiona LouisWafa BouleftourAline RattnerMarie-Thérèse LinossierLaurence VicoAlain GuignandonNature PortfolioarticleBiotechnologyTP248.13-248.65PhysiologyQP1-981ENnpj Microgravity, Vol 3, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biotechnology TP248.13-248.65 Physiology QP1-981
spellingShingle	Biotechnology TP248.13-248.65 Physiology QP1-981 Fiona Louis Wafa Bouleftour Aline Rattner Marie-Thérèse Linossier Laurence Vico Alain Guignandon RhoGTPase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitment
description	Countering Bone Loss in Space A chemical element naturally found for instance in seafood or grains, could counter bone loss from long-term spaceflight. Alain Guignandon and colleagues from the Université de Lyon à St-Etienne in France exposed multipotent embryonic fibroblasts to microgravity conditions similar to those found in space. They found the balance shifted in these stem cells from differentiating to bone-forming cells (osteoblasts) to differentiating to fatty-tissue forming cells (adipocytes). When the cells were treated with strontium, the shift toward osteoblastogenesis was regained. Strontium achieves this by sustaining the activity of two proteins that play a role in bone development but are suppressed in space. Strontium’s effect on the proteins could happen via release of vascular endothelial growth factor, which, under normal gravity conditions, plays a role in committing the cell to differentiation into osteoblasts rather than adipoyctes.
format	article
author	Fiona Louis Wafa Bouleftour Aline Rattner Marie-Thérèse Linossier Laurence Vico Alain Guignandon
author_facet	Fiona Louis Wafa Bouleftour Aline Rattner Marie-Thérèse Linossier Laurence Vico Alain Guignandon
author_sort	Fiona Louis
title	RhoGTPase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitment
title_short	RhoGTPase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitment
title_full	RhoGTPase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitment
title_fullStr	RhoGTPase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitment
title_full_unstemmed	RhoGTPase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitment
title_sort	rhogtpase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitment
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/74b4487b9a43410ab4bb7e9d1adb01a1
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RhoGTPase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitment

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