Procalcitonin metabolomics in the critically ill reveal relationships between inflammation intensity and energy utilization pathways

Abstract Procalcitonin is a biomarker of systemic inflammation and may have importance in the immune response. The metabolic response to elevated procalcitonin in critical illness is not known. The response to inflammation is vitally important to understanding metabolism alterations during extreme s...

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Autores principales:	Hirotada Kobayashi, Karin Amrein, Jessica A. Lasky-Su, Kenneth B. Christopher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/74b49f3ac1674f67bef69711dd30dbad
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spelling	oai:doaj.org-article:74b49f3ac1674f67bef69711dd30dbad2021-12-05T12:12:22ZProcalcitonin metabolomics in the critically ill reveal relationships between inflammation intensity and energy utilization pathways10.1038/s41598-021-02679-02045-2322https://doaj.org/article/74b49f3ac1674f67bef69711dd30dbad2021-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02679-0https://doaj.org/toc/2045-2322Abstract Procalcitonin is a biomarker of systemic inflammation and may have importance in the immune response. The metabolic response to elevated procalcitonin in critical illness is not known. The response to inflammation is vitally important to understanding metabolism alterations during extreme stress. Our aim was to determine if patients with elevated procalcitonin have differences in the metabolomic response to early critical illness. We performed a metabolomics study of the VITdAL-ICU trial where subjects received high dose vitamin D3 or placebo. Mixed-effects modeling was used to study changes in metabolites over time relative to procalcitonin levels adjusted for age, Simplified Acute Physiology Score II, admission diagnosis, day 0 25-hydroxyvitamin D level, and the 25-hydroxyvitamin D response to intervention. With elevated procalcitonin, multiple members of the short and medium chain acylcarnitine, dicarboxylate fatty acid, branched-chain amino acid, and pentose phosphate pathway metabolite classes had significantly positive false discovery rate corrected associations. Further, multiple long chain acylcarnitines and lysophosphatidylcholines had significantly negative false discovery rate corrected associations with elevated procalcitonin. Gaussian graphical model analysis revealed functional modules specific to elevated procalcitonin. Our findings show that metabolite differences exist with increased procalcitonin indicating activation of branched chain amino acid dehydrogenase and a metabolic shift.Hirotada KobayashiKarin AmreinJessica A. Lasky-SuKenneth B. ChristopherNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hirotada Kobayashi Karin Amrein Jessica A. Lasky-Su Kenneth B. Christopher Procalcitonin metabolomics in the critically ill reveal relationships between inflammation intensity and energy utilization pathways
description	Abstract Procalcitonin is a biomarker of systemic inflammation and may have importance in the immune response. The metabolic response to elevated procalcitonin in critical illness is not known. The response to inflammation is vitally important to understanding metabolism alterations during extreme stress. Our aim was to determine if patients with elevated procalcitonin have differences in the metabolomic response to early critical illness. We performed a metabolomics study of the VITdAL-ICU trial where subjects received high dose vitamin D3 or placebo. Mixed-effects modeling was used to study changes in metabolites over time relative to procalcitonin levels adjusted for age, Simplified Acute Physiology Score II, admission diagnosis, day 0 25-hydroxyvitamin D level, and the 25-hydroxyvitamin D response to intervention. With elevated procalcitonin, multiple members of the short and medium chain acylcarnitine, dicarboxylate fatty acid, branched-chain amino acid, and pentose phosphate pathway metabolite classes had significantly positive false discovery rate corrected associations. Further, multiple long chain acylcarnitines and lysophosphatidylcholines had significantly negative false discovery rate corrected associations with elevated procalcitonin. Gaussian graphical model analysis revealed functional modules specific to elevated procalcitonin. Our findings show that metabolite differences exist with increased procalcitonin indicating activation of branched chain amino acid dehydrogenase and a metabolic shift.
format	article
author	Hirotada Kobayashi Karin Amrein Jessica A. Lasky-Su Kenneth B. Christopher
author_facet	Hirotada Kobayashi Karin Amrein Jessica A. Lasky-Su Kenneth B. Christopher
author_sort	Hirotada Kobayashi
title	Procalcitonin metabolomics in the critically ill reveal relationships between inflammation intensity and energy utilization pathways
title_short	Procalcitonin metabolomics in the critically ill reveal relationships between inflammation intensity and energy utilization pathways
title_full	Procalcitonin metabolomics in the critically ill reveal relationships between inflammation intensity and energy utilization pathways
title_fullStr	Procalcitonin metabolomics in the critically ill reveal relationships between inflammation intensity and energy utilization pathways
title_full_unstemmed	Procalcitonin metabolomics in the critically ill reveal relationships between inflammation intensity and energy utilization pathways
title_sort	procalcitonin metabolomics in the critically ill reveal relationships between inflammation intensity and energy utilization pathways
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/74b49f3ac1674f67bef69711dd30dbad
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Procalcitonin metabolomics in the critically ill reveal relationships between inflammation intensity and energy utilization pathways

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