Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells

Yamanaka factors can reprogram somatic and cancer cells into induced pluripotent stem cells. Here, the authors show that the induction of these factors in acute myeloid leukemia leads to apoptosis of leukemia cells in vivo, and this is through modulation of chromatin accessibility to apoptotic genes...

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Autores principales:	Yajie Wang, Ting Lu, Guohuan Sun, Yawei Zheng, Shangda Yang, Hongyan Zhang, Sha Hao, Yanfeng Liu, Shihui Ma, Houyu Zhang, Yongxin Ru, Shaorong Gao, Kuangyu Yen, Hui Cheng, Tao Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/74b5e3075d964424ba332b6b527e4378
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:74b5e3075d964424ba332b6b527e43782021-12-02T14:38:44ZTargeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells10.1038/s41467-019-13411-y2041-1723https://doaj.org/article/74b5e3075d964424ba332b6b527e43782019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13411-yhttps://doaj.org/toc/2041-1723Yamanaka factors can reprogram somatic and cancer cells into induced pluripotent stem cells. Here, the authors show that the induction of these factors in acute myeloid leukemia leads to apoptosis of leukemia cells in vivo, and this is through modulation of chromatin accessibility to apoptotic genes and accompanied by H3K9me3 dysregulation.Yajie WangTing LuGuohuan SunYawei ZhengShangda YangHongyan ZhangSha HaoYanfeng LiuShihui MaHouyu ZhangYongxin RuShaorong GaoKuangyu YenHui ChengTao ChengNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yajie Wang Ting Lu Guohuan Sun Yawei Zheng Shangda Yang Hongyan Zhang Sha Hao Yanfeng Liu Shihui Ma Houyu Zhang Yongxin Ru Shaorong Gao Kuangyu Yen Hui Cheng Tao Cheng Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells
description	Yamanaka factors can reprogram somatic and cancer cells into induced pluripotent stem cells. Here, the authors show that the induction of these factors in acute myeloid leukemia leads to apoptosis of leukemia cells in vivo, and this is through modulation of chromatin accessibility to apoptotic genes and accompanied by H3K9me3 dysregulation.
format	article
author	Yajie Wang Ting Lu Guohuan Sun Yawei Zheng Shangda Yang Hongyan Zhang Sha Hao Yanfeng Liu Shihui Ma Houyu Zhang Yongxin Ru Shaorong Gao Kuangyu Yen Hui Cheng Tao Cheng
author_facet	Yajie Wang Ting Lu Guohuan Sun Yawei Zheng Shangda Yang Hongyan Zhang Sha Hao Yanfeng Liu Shihui Ma Houyu Zhang Yongxin Ru Shaorong Gao Kuangyu Yen Hui Cheng Tao Cheng
author_sort	Yajie Wang
title	Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells
title_short	Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells
title_full	Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells
title_fullStr	Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells
title_full_unstemmed	Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells
title_sort	targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/74b5e3075d964424ba332b6b527e4378
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Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells

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