Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells

Yamanaka factors can reprogram somatic and cancer cells into induced pluripotent stem cells. Here, the authors show that the induction of these factors in acute myeloid leukemia leads to apoptosis of leukemia cells in vivo, and this is through modulation of chromatin accessibility to apoptotic genes...

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Autores principales: Yajie Wang, Ting Lu, Guohuan Sun, Yawei Zheng, Shangda Yang, Hongyan Zhang, Sha Hao, Yanfeng Liu, Shihui Ma, Houyu Zhang, Yongxin Ru, Shaorong Gao, Kuangyu Yen, Hui Cheng, Tao Cheng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/74b5e3075d964424ba332b6b527e4378
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