Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node

Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node

Tumor neoantigens can be drained to the lymph nodes, but the nature and the significance of the induced immune responses are still unclear. Here the authors use a mouse genetic tumor model to show that tumor-specific CD4 T cells can become anergic or suppressive in the draining lymph node to modulat...

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Autores principales: Ruby Alonso, Héloïse Flament, Sébastien Lemoine, Christine Sedlik, Emanuel Bottasso, Isabel Péguillet, Virginie Prémel, Jordan Denizeau, Marion Salou, Aurélie Darbois, Nicolás Gonzalo Núñez, Benoit Salomon, David Gross, Eliane Piaggio, Olivier Lantz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/74b8aa3d1148474e8cae7856e61a4c79
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Sumario:Tumor neoantigens can be drained to the lymph nodes, but the nature and the significance of the induced immune responses are still unclear. Here the authors use a mouse genetic tumor model to show that tumor-specific CD4 T cells can become anergic or suppressive in the draining lymph node to modulate tumor immunity.

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