Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node

Tumor neoantigens can be drained to the lymph nodes, but the nature and the significance of the induced immune responses are still unclear. Here the authors use a mouse genetic tumor model to show that tumor-specific CD4 T cells can become anergic or suppressive in the draining lymph node to modulat...

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Autores principales:	Ruby Alonso, Héloïse Flament, Sébastien Lemoine, Christine Sedlik, Emanuel Bottasso, Isabel Péguillet, Virginie Prémel, Jordan Denizeau, Marion Salou, Aurélie Darbois, Nicolás Gonzalo Núñez, Benoit Salomon, David Gross, Eliane Piaggio, Olivier Lantz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/74b8aa3d1148474e8cae7856e61a4c79
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spelling	oai:doaj.org-article:74b8aa3d1148474e8cae7856e61a4c792021-12-02T16:56:43ZInduction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node10.1038/s41467-018-04524-x2041-1723https://doaj.org/article/74b8aa3d1148474e8cae7856e61a4c792018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04524-xhttps://doaj.org/toc/2041-1723Tumor neoantigens can be drained to the lymph nodes, but the nature and the significance of the induced immune responses are still unclear. Here the authors use a mouse genetic tumor model to show that tumor-specific CD4 T cells can become anergic or suppressive in the draining lymph node to modulate tumor immunity.Ruby AlonsoHéloïse FlamentSébastien LemoineChristine SedlikEmanuel BottassoIsabel PéguilletVirginie PrémelJordan DenizeauMarion SalouAurélie DarboisNicolás Gonzalo NúñezBenoit SalomonDavid GrossEliane PiaggioOlivier LantzNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ruby Alonso Héloïse Flament Sébastien Lemoine Christine Sedlik Emanuel Bottasso Isabel Péguillet Virginie Prémel Jordan Denizeau Marion Salou Aurélie Darbois Nicolás Gonzalo Núñez Benoit Salomon David Gross Eliane Piaggio Olivier Lantz Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node
description	Tumor neoantigens can be drained to the lymph nodes, but the nature and the significance of the induced immune responses are still unclear. Here the authors use a mouse genetic tumor model to show that tumor-specific CD4 T cells can become anergic or suppressive in the draining lymph node to modulate tumor immunity.
format	article
author	Ruby Alonso Héloïse Flament Sébastien Lemoine Christine Sedlik Emanuel Bottasso Isabel Péguillet Virginie Prémel Jordan Denizeau Marion Salou Aurélie Darbois Nicolás Gonzalo Núñez Benoit Salomon David Gross Eliane Piaggio Olivier Lantz
author_facet	Ruby Alonso Héloïse Flament Sébastien Lemoine Christine Sedlik Emanuel Bottasso Isabel Péguillet Virginie Prémel Jordan Denizeau Marion Salou Aurélie Darbois Nicolás Gonzalo Núñez Benoit Salomon David Gross Eliane Piaggio Olivier Lantz
author_sort	Ruby Alonso
title	Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node
title_short	Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node
title_full	Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node
title_fullStr	Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node
title_full_unstemmed	Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node
title_sort	induction of anergic or regulatory tumor-specific cd4+ t cells in the tumor-draining lymph node
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/74b8aa3d1148474e8cae7856e61a4c79
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Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node

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