Quantitative Magnetic Resonance Imaging in Perianal Crohn’s Disease at 1.5 and 3.0 T: A Feasibility Study

Perianal Crohn’s Disease (pCD) is a common manifestation of Crohn’s Disease. Absence of reliable disease measures makes disease monitoring unreliable. Qualitative MRI has been increasingly used for diagnosing and monitoring pCD and has shown potential for assessing response to treatment. Quantitativ...

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Autores principales:	Ali Alyami, Caroline L. Hoad, Christopher Tench, Uday Bannur, Christopher Clarke, Khalid Latief, Konstantinos Argyriou, Alan Lobo, Philip Lung, Rachel Baldwin-Cleland, Kapil Sahnan, Ailsa Hart, Jimmy K. Limdi, John Mclaughlin, David Atkinson, Geoffrey J. M. Parker, James P. B. O’Connor, Ross A. Little, Penny A. Gowland, Gordon W. Moran
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	perianal Crohn’s disease quantitative MRI MT DWI T2 DCE Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/74ba319f25de4b3fae15fcb087fe6c40
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spelling	oai:doaj.org-article:74ba319f25de4b3fae15fcb087fe6c402021-11-25T17:21:55ZQuantitative Magnetic Resonance Imaging in Perianal Crohn’s Disease at 1.5 and 3.0 T: A Feasibility Study10.3390/diagnostics111121352075-4418https://doaj.org/article/74ba319f25de4b3fae15fcb087fe6c402021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2135https://doaj.org/toc/2075-4418Perianal Crohn’s Disease (pCD) is a common manifestation of Crohn’s Disease. Absence of reliable disease measures makes disease monitoring unreliable. Qualitative MRI has been increasingly used for diagnosing and monitoring pCD and has shown potential for assessing response to treatment. Quantitative MRI sequences, such as diffusion-weighted imaging (DWI), dynamic contrast enhancement (DCE) and magnetisation transfer (MT), along with T2 relaxometry, offer opportunities to improve diagnostic capability. Quantitative MRI sequences (DWI, DCE, MT and T2) were used in a cohort of 25 pCD patients before and 12 weeks after biological therapy at two different field strengths (1.5 and 3 T). Disease activity was measured with the Perianal Crohn’s Disease Activity index (PDAI) and serum C-reactive protein (CRP). Diseased tissue areas on MRI were defined by a radiologist. A baseline model to predict outcome at 12 weeks was developed. No differences were seen in the quantitative MR measured in the diseased tissue regions from baseline to 12 weeks; however, PDAI and CRP decreased. Baseline PDAI, CRP, T2 relaxometry and surgical history were found to have a moderate ability to predict response after 12 weeks of biological treatment. Validation in larger cohorts with MRI and clinical measures are needed in order to further develop the model.Ali AlyamiCaroline L. HoadChristopher TenchUday BannurChristopher ClarkeKhalid LatiefKonstantinos ArgyriouAlan LoboPhilip LungRachel Baldwin-ClelandKapil SahnanAilsa HartJimmy K. LimdiJohn MclaughlinDavid AtkinsonGeoffrey J. M. ParkerJames P. B. O’ConnorRoss A. LittlePenny A. GowlandGordon W. MoranMDPI AGarticleperianal Crohn’s diseasequantitative MRIMTDWIT2DCEMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2135, p 2135 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	perianal Crohn’s disease quantitative MRI MT DWI T2 DCE Medicine (General) R5-920
spellingShingle	perianal Crohn’s disease quantitative MRI MT DWI T2 DCE Medicine (General) R5-920 Ali Alyami Caroline L. Hoad Christopher Tench Uday Bannur Christopher Clarke Khalid Latief Konstantinos Argyriou Alan Lobo Philip Lung Rachel Baldwin-Cleland Kapil Sahnan Ailsa Hart Jimmy K. Limdi John Mclaughlin David Atkinson Geoffrey J. M. Parker James P. B. O’Connor Ross A. Little Penny A. Gowland Gordon W. Moran Quantitative Magnetic Resonance Imaging in Perianal Crohn’s Disease at 1.5 and 3.0 T: A Feasibility Study
description	Perianal Crohn’s Disease (pCD) is a common manifestation of Crohn’s Disease. Absence of reliable disease measures makes disease monitoring unreliable. Qualitative MRI has been increasingly used for diagnosing and monitoring pCD and has shown potential for assessing response to treatment. Quantitative MRI sequences, such as diffusion-weighted imaging (DWI), dynamic contrast enhancement (DCE) and magnetisation transfer (MT), along with T2 relaxometry, offer opportunities to improve diagnostic capability. Quantitative MRI sequences (DWI, DCE, MT and T2) were used in a cohort of 25 pCD patients before and 12 weeks after biological therapy at two different field strengths (1.5 and 3 T). Disease activity was measured with the Perianal Crohn’s Disease Activity index (PDAI) and serum C-reactive protein (CRP). Diseased tissue areas on MRI were defined by a radiologist. A baseline model to predict outcome at 12 weeks was developed. No differences were seen in the quantitative MR measured in the diseased tissue regions from baseline to 12 weeks; however, PDAI and CRP decreased. Baseline PDAI, CRP, T2 relaxometry and surgical history were found to have a moderate ability to predict response after 12 weeks of biological treatment. Validation in larger cohorts with MRI and clinical measures are needed in order to further develop the model.
format	article
author	Ali Alyami Caroline L. Hoad Christopher Tench Uday Bannur Christopher Clarke Khalid Latief Konstantinos Argyriou Alan Lobo Philip Lung Rachel Baldwin-Cleland Kapil Sahnan Ailsa Hart Jimmy K. Limdi John Mclaughlin David Atkinson Geoffrey J. M. Parker James P. B. O’Connor Ross A. Little Penny A. Gowland Gordon W. Moran
author_facet	Ali Alyami Caroline L. Hoad Christopher Tench Uday Bannur Christopher Clarke Khalid Latief Konstantinos Argyriou Alan Lobo Philip Lung Rachel Baldwin-Cleland Kapil Sahnan Ailsa Hart Jimmy K. Limdi John Mclaughlin David Atkinson Geoffrey J. M. Parker James P. B. O’Connor Ross A. Little Penny A. Gowland Gordon W. Moran
author_sort	Ali Alyami
title	Quantitative Magnetic Resonance Imaging in Perianal Crohn’s Disease at 1.5 and 3.0 T: A Feasibility Study
title_short	Quantitative Magnetic Resonance Imaging in Perianal Crohn’s Disease at 1.5 and 3.0 T: A Feasibility Study
title_full	Quantitative Magnetic Resonance Imaging in Perianal Crohn’s Disease at 1.5 and 3.0 T: A Feasibility Study
title_fullStr	Quantitative Magnetic Resonance Imaging in Perianal Crohn’s Disease at 1.5 and 3.0 T: A Feasibility Study
title_full_unstemmed	Quantitative Magnetic Resonance Imaging in Perianal Crohn’s Disease at 1.5 and 3.0 T: A Feasibility Study
title_sort	quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 t: a feasibility study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/74ba319f25de4b3fae15fcb087fe6c40
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Quantitative Magnetic Resonance Imaging in Perianal Crohn’s Disease at 1.5 and 3.0 T: A Feasibility Study

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