Allele frequencies of single nucleotide polymorphisms of clinically important drug-metabolizing enzymes CYP2C9, CYP2C19, and CYP3A4 in a Thai population

Abstract Prior knowledge of allele frequencies of cytochrome P450 polymorphisms in a population is crucial for the revision and optimization of existing medication choices and doses. In the current study, the frequency of the CYP2C9*2, CYP2C9*3, CYP2C19*2, CYP2C19*3, CYP2C19*6, CYP2C19*17, and CYP3A...

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Autores principales:	Rattanaporn Sukprasong, Sumonrat Chuwongwattana, Napatrupron Koomdee, Thawinee Jantararoungtong, Santirhat Prommas, Pimonpan Jinda, Jiratha Rachanakul, Nutthan Nuntharadthanaphong, Nutcha Jongjitsook, Apichaya Puangpetch, Chonlaphat Sukasem
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/74bcb67535044068aa1971e2450ebe29
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spelling	oai:doaj.org-article:74bcb67535044068aa1971e2450ebe292021-12-02T17:47:03ZAllele frequencies of single nucleotide polymorphisms of clinically important drug-metabolizing enzymes CYP2C9, CYP2C19, and CYP3A4 in a Thai population10.1038/s41598-021-90969-y2045-2322https://doaj.org/article/74bcb67535044068aa1971e2450ebe292021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90969-yhttps://doaj.org/toc/2045-2322Abstract Prior knowledge of allele frequencies of cytochrome P450 polymorphisms in a population is crucial for the revision and optimization of existing medication choices and doses. In the current study, the frequency of the CYP2C92, CYP2C93, CYP2C192, CYP2C193, CYP2C196, CYP2C1917, and CYP3A4 (rs4646437) alleles in a Thai population across different regions of Thailand was examined. Tests for polymorphisms of CYP2C9 and CYP3A4 were performed using TaqMan SNP genotyping assay and CYP2C19 was performed using two different methods; TaqMan SNP genotyping assay and Luminex x Tag V3. The blood samples were collected from 1205 unrelated healthy individuals across different regions within Thailand. Polymorphisms of CYP2C9 and CYP2C19 were transformed into phenotypes, which included normal metabolizer (NM), intermediate metabolizer (IM), poor metabolizer (PM), and rapid metabolizers (RM). The CYP2C9 allele frequencies among the Thai population were 0.08% and 5.27% for the CYP2C92 and CYP2C93 alleles, respectively. The CYP2C19 allele frequencies among the Thai population were 25.60%, 2.50%, 0.10%, and 1.80% for the CYP2C192, CYP2C193, CYP2C196, and CYP2C1917 alleles, respectively. The allele frequency of the CYP3A4 (rs4646437) variant allele was 28.50% in the Thai population. The frequency of the CYP2C93 allele was significantly lower among the Northern Thai population (P < 0.001). The frequency of the CYP2C1917 allele was significantly higher in the Southern Thai population (P < 0.001). Our results may provide an understanding of the ethnic differences in drug responses and support for the utilization of pharmacogenomics testing in clinical practice.Rattanaporn SukprasongSumonrat ChuwongwattanaNapatrupron KoomdeeThawinee JantararoungtongSantirhat PrommasPimonpan JindaJiratha RachanakulNutthan NuntharadthanaphongNutcha JongjitsookApichaya PuangpetchChonlaphat SukasemNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rattanaporn Sukprasong Sumonrat Chuwongwattana Napatrupron Koomdee Thawinee Jantararoungtong Santirhat Prommas Pimonpan Jinda Jiratha Rachanakul Nutthan Nuntharadthanaphong Nutcha Jongjitsook Apichaya Puangpetch Chonlaphat Sukasem Allele frequencies of single nucleotide polymorphisms of clinically important drug-metabolizing enzymes CYP2C9, CYP2C19, and CYP3A4 in a Thai population
description	Abstract Prior knowledge of allele frequencies of cytochrome P450 polymorphisms in a population is crucial for the revision and optimization of existing medication choices and doses. In the current study, the frequency of the CYP2C92, CYP2C93, CYP2C192, CYP2C193, CYP2C196, CYP2C1917, and CYP3A4 (rs4646437) alleles in a Thai population across different regions of Thailand was examined. Tests for polymorphisms of CYP2C9 and CYP3A4 were performed using TaqMan SNP genotyping assay and CYP2C19 was performed using two different methods; TaqMan SNP genotyping assay and Luminex x Tag V3. The blood samples were collected from 1205 unrelated healthy individuals across different regions within Thailand. Polymorphisms of CYP2C9 and CYP2C19 were transformed into phenotypes, which included normal metabolizer (NM), intermediate metabolizer (IM), poor metabolizer (PM), and rapid metabolizers (RM). The CYP2C9 allele frequencies among the Thai population were 0.08% and 5.27% for the CYP2C92 and CYP2C93 alleles, respectively. The CYP2C19 allele frequencies among the Thai population were 25.60%, 2.50%, 0.10%, and 1.80% for the CYP2C192, CYP2C193, CYP2C196, and CYP2C1917 alleles, respectively. The allele frequency of the CYP3A4 (rs4646437) variant allele was 28.50% in the Thai population. The frequency of the CYP2C93 allele was significantly lower among the Northern Thai population (P < 0.001). The frequency of the CYP2C1917 allele was significantly higher in the Southern Thai population (P < 0.001). Our results may provide an understanding of the ethnic differences in drug responses and support for the utilization of pharmacogenomics testing in clinical practice.
format	article
author	Rattanaporn Sukprasong Sumonrat Chuwongwattana Napatrupron Koomdee Thawinee Jantararoungtong Santirhat Prommas Pimonpan Jinda Jiratha Rachanakul Nutthan Nuntharadthanaphong Nutcha Jongjitsook Apichaya Puangpetch Chonlaphat Sukasem
author_facet	Rattanaporn Sukprasong Sumonrat Chuwongwattana Napatrupron Koomdee Thawinee Jantararoungtong Santirhat Prommas Pimonpan Jinda Jiratha Rachanakul Nutthan Nuntharadthanaphong Nutcha Jongjitsook Apichaya Puangpetch Chonlaphat Sukasem
author_sort	Rattanaporn Sukprasong
title	Allele frequencies of single nucleotide polymorphisms of clinically important drug-metabolizing enzymes CYP2C9, CYP2C19, and CYP3A4 in a Thai population
title_short	Allele frequencies of single nucleotide polymorphisms of clinically important drug-metabolizing enzymes CYP2C9, CYP2C19, and CYP3A4 in a Thai population
title_full	Allele frequencies of single nucleotide polymorphisms of clinically important drug-metabolizing enzymes CYP2C9, CYP2C19, and CYP3A4 in a Thai population
title_fullStr	Allele frequencies of single nucleotide polymorphisms of clinically important drug-metabolizing enzymes CYP2C9, CYP2C19, and CYP3A4 in a Thai population
title_full_unstemmed	Allele frequencies of single nucleotide polymorphisms of clinically important drug-metabolizing enzymes CYP2C9, CYP2C19, and CYP3A4 in a Thai population
title_sort	allele frequencies of single nucleotide polymorphisms of clinically important drug-metabolizing enzymes cyp2c9, cyp2c19, and cyp3a4 in a thai population
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/74bcb67535044068aa1971e2450ebe29
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Allele frequencies of single nucleotide polymorphisms of clinically important drug-metabolizing enzymes CYP2C9, CYP2C19, and CYP3A4 in a Thai population

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