Local activation of α2 adrenergic receptors is required for vagus nerve stimulation induced motor cortical plasticity

Abstract Vagus nerve stimulation (VNS) paired with rehabilitation training is emerging as a potential treatment for improving recovery of motor function following stroke. In rats, VNS paired with skilled forelimb training results in significant reorganization of the somatotopic cortical motor map; h...

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Autores principales:	Ching-Tzu Tseng, Solomon J. Gaulding, Canice Lei E. Dancel, Catherine A. Thorn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/74bdf85fb7e149e3a12404ae5fda9df6
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spelling	oai:doaj.org-article:74bdf85fb7e149e3a12404ae5fda9df62021-11-08T10:53:03ZLocal activation of α2 adrenergic receptors is required for vagus nerve stimulation induced motor cortical plasticity10.1038/s41598-021-00976-22045-2322https://doaj.org/article/74bdf85fb7e149e3a12404ae5fda9df62021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00976-2https://doaj.org/toc/2045-2322Abstract Vagus nerve stimulation (VNS) paired with rehabilitation training is emerging as a potential treatment for improving recovery of motor function following stroke. In rats, VNS paired with skilled forelimb training results in significant reorganization of the somatotopic cortical motor map; however, the mechanisms underlying this form of VNS-dependent plasticity remain unclear. Recent studies have shown that VNS-driven cortical plasticity is dependent on noradrenergic innervation of the neocortex. In the central nervous system, noradrenergic α2 receptors (α2-ARs) are widely expressed in the motor cortex and have been critically implicated in synaptic communication and plasticity. In current study, we examined whether activation of cortical α2-ARs is necessary for VNS-driven motor cortical reorganization to occur. Consistent with previous studies, we found that VNS paired with motor training enlarges the map representation of task-relevant musculature in the motor cortex. Infusion of α2-AR antagonists into M1 blocked VNS-driven motor map reorganization from occurring. Our results suggest that local α2-AR activation is required for VNS-induced cortical reorganization to occur, providing insight into the mechanisms that may underlie the neuroplastic effects of VNS therapy.Ching-Tzu TsengSolomon J. GauldingCanice Lei E. DancelCatherine A. ThornNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ching-Tzu Tseng Solomon J. Gaulding Canice Lei E. Dancel Catherine A. Thorn Local activation of α2 adrenergic receptors is required for vagus nerve stimulation induced motor cortical plasticity
description	Abstract Vagus nerve stimulation (VNS) paired with rehabilitation training is emerging as a potential treatment for improving recovery of motor function following stroke. In rats, VNS paired with skilled forelimb training results in significant reorganization of the somatotopic cortical motor map; however, the mechanisms underlying this form of VNS-dependent plasticity remain unclear. Recent studies have shown that VNS-driven cortical plasticity is dependent on noradrenergic innervation of the neocortex. In the central nervous system, noradrenergic α2 receptors (α2-ARs) are widely expressed in the motor cortex and have been critically implicated in synaptic communication and plasticity. In current study, we examined whether activation of cortical α2-ARs is necessary for VNS-driven motor cortical reorganization to occur. Consistent with previous studies, we found that VNS paired with motor training enlarges the map representation of task-relevant musculature in the motor cortex. Infusion of α2-AR antagonists into M1 blocked VNS-driven motor map reorganization from occurring. Our results suggest that local α2-AR activation is required for VNS-induced cortical reorganization to occur, providing insight into the mechanisms that may underlie the neuroplastic effects of VNS therapy.
format	article
author	Ching-Tzu Tseng Solomon J. Gaulding Canice Lei E. Dancel Catherine A. Thorn
author_facet	Ching-Tzu Tseng Solomon J. Gaulding Canice Lei E. Dancel Catherine A. Thorn
author_sort	Ching-Tzu Tseng
title	Local activation of α2 adrenergic receptors is required for vagus nerve stimulation induced motor cortical plasticity
title_short	Local activation of α2 adrenergic receptors is required for vagus nerve stimulation induced motor cortical plasticity
title_full	Local activation of α2 adrenergic receptors is required for vagus nerve stimulation induced motor cortical plasticity
title_fullStr	Local activation of α2 adrenergic receptors is required for vagus nerve stimulation induced motor cortical plasticity
title_full_unstemmed	Local activation of α2 adrenergic receptors is required for vagus nerve stimulation induced motor cortical plasticity
title_sort	local activation of α2 adrenergic receptors is required for vagus nerve stimulation induced motor cortical plasticity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/74bdf85fb7e149e3a12404ae5fda9df6
work_keys_str_mv	AT chingtzutseng localactivationofa2adrenergicreceptorsisrequiredforvagusnervestimulationinducedmotorcorticalplasticity AT solomonjgaulding localactivationofa2adrenergicreceptorsisrequiredforvagusnervestimulationinducedmotorcorticalplasticity AT caniceleiedancel localactivationofa2adrenergicreceptorsisrequiredforvagusnervestimulationinducedmotorcorticalplasticity AT catherineathorn localactivationofa2adrenergicreceptorsisrequiredforvagusnervestimulationinducedmotorcorticalplasticity
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Local activation of α2 adrenergic receptors is required for vagus nerve stimulation induced motor cortical plasticity

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