Serum and brain natural copper stable isotopes in a mouse model of Alzheimer’s disease

Abstract Alzheimer’s disease is associated with the production of Cu rich aβ fibrils. Because monitoring the changes in Cu level of organs has been proposed to follow the evolution of the disease, we analyzed the copper isotopic composition of serum and brain of APPswe/PSEN1dE9 transgenic mice, a mo...

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Autores principales:	Frédéric Moynier, John Creech, Jessica Dallas, Marie Le Borgne
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/74bea38f49124f2a94dab93061ab66e4
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spelling	oai:doaj.org-article:74bea38f49124f2a94dab93061ab66e42021-12-02T16:08:16ZSerum and brain natural copper stable isotopes in a mouse model of Alzheimer’s disease10.1038/s41598-019-47790-52045-2322https://doaj.org/article/74bea38f49124f2a94dab93061ab66e42019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-47790-5https://doaj.org/toc/2045-2322Abstract Alzheimer’s disease is associated with the production of Cu rich aβ fibrils. Because monitoring the changes in Cu level of organs has been proposed to follow the evolution of the disease, we analyzed the copper isotopic composition of serum and brain of APPswe/PSEN1dE9 transgenic mice, a model of Alzheimer’s disease, and wild-type (WT) controls. Serum composition of 3, 6, 9 and 12-month-old mice, as well as the composition of 9 brains of 12-month-old mice are reported. In WT mice, brains were ~1‰ isotopically heavier than serum, and the Cu isotopic composition of the serum was isotopically different between males and females. We propose that this effect of sex on the Cu isotopic budget of the serum may be related to a difference of Cu speciation and relative abundance of Cu carriers. Brains of APPswe/PSEN1dE9 mice were slightly lighter than brains of WT mice, while not statistically significant. This trend may reflect an increase of Cu(I) associated with the formation of Aβ fibrils. The Cu isotopic composition of the brains and serum were correlated, implying copper transport between these two reservoirs, in particular a transfer of Cu(I) from the brain to the serum. Altogether, these data suggest that Cu stable isotopic composition of body fluid may have the potential to be used as detection tools for the formation of Aβ fibrils in the brain, but further work has to be done.Frédéric MoynierJohn CreechJessica DallasMarie Le BorgneNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Frédéric Moynier John Creech Jessica Dallas Marie Le Borgne Serum and brain natural copper stable isotopes in a mouse model of Alzheimer’s disease
description	Abstract Alzheimer’s disease is associated with the production of Cu rich aβ fibrils. Because monitoring the changes in Cu level of organs has been proposed to follow the evolution of the disease, we analyzed the copper isotopic composition of serum and brain of APPswe/PSEN1dE9 transgenic mice, a model of Alzheimer’s disease, and wild-type (WT) controls. Serum composition of 3, 6, 9 and 12-month-old mice, as well as the composition of 9 brains of 12-month-old mice are reported. In WT mice, brains were ~1‰ isotopically heavier than serum, and the Cu isotopic composition of the serum was isotopically different between males and females. We propose that this effect of sex on the Cu isotopic budget of the serum may be related to a difference of Cu speciation and relative abundance of Cu carriers. Brains of APPswe/PSEN1dE9 mice were slightly lighter than brains of WT mice, while not statistically significant. This trend may reflect an increase of Cu(I) associated with the formation of Aβ fibrils. The Cu isotopic composition of the brains and serum were correlated, implying copper transport between these two reservoirs, in particular a transfer of Cu(I) from the brain to the serum. Altogether, these data suggest that Cu stable isotopic composition of body fluid may have the potential to be used as detection tools for the formation of Aβ fibrils in the brain, but further work has to be done.
format	article
author	Frédéric Moynier John Creech Jessica Dallas Marie Le Borgne
author_facet	Frédéric Moynier John Creech Jessica Dallas Marie Le Borgne
author_sort	Frédéric Moynier
title	Serum and brain natural copper stable isotopes in a mouse model of Alzheimer’s disease
title_short	Serum and brain natural copper stable isotopes in a mouse model of Alzheimer’s disease
title_full	Serum and brain natural copper stable isotopes in a mouse model of Alzheimer’s disease
title_fullStr	Serum and brain natural copper stable isotopes in a mouse model of Alzheimer’s disease
title_full_unstemmed	Serum and brain natural copper stable isotopes in a mouse model of Alzheimer’s disease
title_sort	serum and brain natural copper stable isotopes in a mouse model of alzheimer’s disease
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/74bea38f49124f2a94dab93061ab66e4
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Serum and brain natural copper stable isotopes in a mouse model of Alzheimer’s disease

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