Association of Life-Course Educational Attainment and Breast Cancer Grade in the MEND Study

Background: Nigeria reports the highest age-standardized mortality rate for breast cancer (BC) among African countries and disproportionately high rates of high-grade cancer. Histological grade is a strong predictor of mortality, and evidence suggests that educational attainment influences cancer ou...

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Autores principales:	Anjali Gupta, Kelley Jones, April Deveaux, Malcolm Bevel, Omolola Salako, Adetola Daramola, Allison Hall, Olusegun Alatise, Gabriel Ogun, Adewale Adeniyi, Akinlolu Ojo, Omobolaji Ayandipo, Thomas Olajide, Olalekan Olasehinde, Olukayode Arowolo, Adewale Adisa, Oludolapo Afuwape, Aralola Olusanya, Aderemi Adegoke, Trygve O. Tollefsbol, Donna Arnett, Christopher B. Newgard, Tomi Akinyemiju
Formato:	article
Lenguaje:	EN
Publicado:	Ubiquity Press 2021
Materias:	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/74c0a716fc504a859a639c9769cf20cb
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spelling	oai:doaj.org-article:74c0a716fc504a859a639c9769cf20cb2021-12-02T16:34:27ZAssociation of Life-Course Educational Attainment and Breast Cancer Grade in the MEND Study2214-999610.5334/aogh.3142https://doaj.org/article/74c0a716fc504a859a639c9769cf20cb2021-07-01T00:00:00Zhttps://annalsofglobalhealth.org/articles/3142https://doaj.org/toc/2214-9996Background: Nigeria reports the highest age-standardized mortality rate for breast cancer (BC) among African countries and disproportionately high rates of high-grade cancer. Histological grade is a strong predictor of mortality, and evidence suggests that educational attainment influences cancer outcomes. Objective: We characterize the association between educational trends across the life-course and BC grade at diagnosis. Methods: Data on 224 BC patients enrolled in the Mechanisms for Established and Novel Risk Factors for Breast Cancer in Nigerian Women (MEND) study was analyzed. Participant and parental (mother and father) education was categorized as low (primary school or less) or high (secondary school or greater). Accordingly, the educational trend across the life-course was determined for each participant relative to each parent: stable high, increasing, decreasing, or stable low. BC grade was classified as high (grade 3) or low (grades 1–2). Findings: About 34% of participants, 71% of fathers, and 85% of mothers had low education. Approximately one-third of participants were diagnosed with high-grade BC. Participants with low-grade BC were more likely to have highly educated fathers (p = 0.04). After adjusting for age, comorbidities, marital status and mammogram screening, participants with highly educated fathers were 60% less likely to have high-grade BC (aOR 0.41; 95% CI 0.20 to 0.84) compared to those with less-educated fathers. Stable high life-course education relative to father was also associated with a significantly lower likelihood of having high-grade BC (aOR 0.36; 95% CI 0.15 to 0.87) compared to stable low life-course education. No significant associations were observed for the participant’s education, mother’s education, or life-course education relative to mother. Conclusions: Early-life socioeconomic status (SES) may influence BC grade. This deserves further study to inform policies that may be useful in reducing high-grade BC in Nigeria.Anjali GuptaKelley JonesApril DeveauxMalcolm BevelOmolola SalakoAdetola DaramolaAllison HallOlusegun AlatiseGabriel OgunAdewale AdeniyiAkinlolu OjoOmobolaji AyandipoThomas OlajideOlalekan OlasehindeOlukayode ArowoloAdewale AdisaOludolapo AfuwapeAralola OlusanyaAderemi AdegokeTrygve O. TollefsbolDonna ArnettChristopher B. NewgardTomi AkinyemijuUbiquity PressarticleInfectious and parasitic diseasesRC109-216Public aspects of medicineRA1-1270ENAnnals of Global Health, Vol 87, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
spellingShingle	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270 Anjali Gupta Kelley Jones April Deveaux Malcolm Bevel Omolola Salako Adetola Daramola Allison Hall Olusegun Alatise Gabriel Ogun Adewale Adeniyi Akinlolu Ojo Omobolaji Ayandipo Thomas Olajide Olalekan Olasehinde Olukayode Arowolo Adewale Adisa Oludolapo Afuwape Aralola Olusanya Aderemi Adegoke Trygve O. Tollefsbol Donna Arnett Christopher B. Newgard Tomi Akinyemiju Association of Life-Course Educational Attainment and Breast Cancer Grade in the MEND Study
description	Background: Nigeria reports the highest age-standardized mortality rate for breast cancer (BC) among African countries and disproportionately high rates of high-grade cancer. Histological grade is a strong predictor of mortality, and evidence suggests that educational attainment influences cancer outcomes. Objective: We characterize the association between educational trends across the life-course and BC grade at diagnosis. Methods: Data on 224 BC patients enrolled in the Mechanisms for Established and Novel Risk Factors for Breast Cancer in Nigerian Women (MEND) study was analyzed. Participant and parental (mother and father) education was categorized as low (primary school or less) or high (secondary school or greater). Accordingly, the educational trend across the life-course was determined for each participant relative to each parent: stable high, increasing, decreasing, or stable low. BC grade was classified as high (grade 3) or low (grades 1–2). Findings: About 34% of participants, 71% of fathers, and 85% of mothers had low education. Approximately one-third of participants were diagnosed with high-grade BC. Participants with low-grade BC were more likely to have highly educated fathers (p = 0.04). After adjusting for age, comorbidities, marital status and mammogram screening, participants with highly educated fathers were 60% less likely to have high-grade BC (aOR 0.41; 95% CI 0.20 to 0.84) compared to those with less-educated fathers. Stable high life-course education relative to father was also associated with a significantly lower likelihood of having high-grade BC (aOR 0.36; 95% CI 0.15 to 0.87) compared to stable low life-course education. No significant associations were observed for the participant’s education, mother’s education, or life-course education relative to mother. Conclusions: Early-life socioeconomic status (SES) may influence BC grade. This deserves further study to inform policies that may be useful in reducing high-grade BC in Nigeria.
format	article
author	Anjali Gupta Kelley Jones April Deveaux Malcolm Bevel Omolola Salako Adetola Daramola Allison Hall Olusegun Alatise Gabriel Ogun Adewale Adeniyi Akinlolu Ojo Omobolaji Ayandipo Thomas Olajide Olalekan Olasehinde Olukayode Arowolo Adewale Adisa Oludolapo Afuwape Aralola Olusanya Aderemi Adegoke Trygve O. Tollefsbol Donna Arnett Christopher B. Newgard Tomi Akinyemiju
author_facet	Anjali Gupta Kelley Jones April Deveaux Malcolm Bevel Omolola Salako Adetola Daramola Allison Hall Olusegun Alatise Gabriel Ogun Adewale Adeniyi Akinlolu Ojo Omobolaji Ayandipo Thomas Olajide Olalekan Olasehinde Olukayode Arowolo Adewale Adisa Oludolapo Afuwape Aralola Olusanya Aderemi Adegoke Trygve O. Tollefsbol Donna Arnett Christopher B. Newgard Tomi Akinyemiju
author_sort	Anjali Gupta
title	Association of Life-Course Educational Attainment and Breast Cancer Grade in the MEND Study
title_short	Association of Life-Course Educational Attainment and Breast Cancer Grade in the MEND Study
title_full	Association of Life-Course Educational Attainment and Breast Cancer Grade in the MEND Study
title_fullStr	Association of Life-Course Educational Attainment and Breast Cancer Grade in the MEND Study
title_full_unstemmed	Association of Life-Course Educational Attainment and Breast Cancer Grade in the MEND Study
title_sort	association of life-course educational attainment and breast cancer grade in the mend study
publisher	Ubiquity Press
publishDate	2021
url	https://doaj.org/article/74c0a716fc504a859a639c9769cf20cb
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Association of Life-Course Educational Attainment and Breast Cancer Grade in the MEND Study

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