The effect of 808 nm and 905 nm wavelength light on recovery after spinal cord injury

Abstract We investigated the effect of a Multiwave Locked System laser (with a simultaneous 808 nm continuous emission and 905 nm pulse emission) on the spinal cord after spinal cord injury (SCI) in rats. The functional recovery was measured by locomotor tests (BBB, Beam walking, MotoRater) and a se...

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Autores principales:	Barbora Svobodova, Anna Kloudova, Jiri Ruzicka, Ludmila Kajtmanova, Leos Navratil, Radek Sedlacek, Tomas Suchy, Meena Jhanwar-Uniyal, Pavla Jendelova, Lucia Machova Urdzikova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/74c6f68c594d436b84386b9795b5b6b1
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spelling	oai:doaj.org-article:74c6f68c594d436b84386b9795b5b6b12021-12-02T15:09:24ZThe effect of 808 nm and 905 nm wavelength light on recovery after spinal cord injury10.1038/s41598-019-44141-22045-2322https://doaj.org/article/74c6f68c594d436b84386b9795b5b6b12019-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-44141-2https://doaj.org/toc/2045-2322Abstract We investigated the effect of a Multiwave Locked System laser (with a simultaneous 808 nm continuous emission and 905 nm pulse emission) on the spinal cord after spinal cord injury (SCI) in rats. The functional recovery was measured by locomotor tests (BBB, Beam walking, MotoRater) and a sensitivity test (Plantar test). The locomotor tests showed a significant improvement of the locomotor functions of the rats after laser treatment from the first week following lesioning, compared to the controls. The laser treatment significantly diminished thermal hyperalgesia after SCI as measured by the Plantar test. The atrophy of the soleus muscle was reduced in the laser treated rats. The histopathological investigation showed a positive effect of the laser therapy on white and gray matter sparing. Our data suggests an upregulation of M2 macrophages in laser treated animals by the increasing number of double labeled CD68+/CD206+ cells in the cranial and central parts of the lesion, compared to the control animals. A shift in microglial/macrophage polarization was confirmed by gene expression analysis by significant mRNA downregulation of Cd86 (marker of inflammatory M1), and non-significant upregulation of Arg1 (marker of M2). These results demonstrated that the combination of 808 nm and 905 nm wavelength light is a promising non-invasive therapy for improving functional recovery and tissue sparing after SCI.Barbora SvobodovaAnna KloudovaJiri RuzickaLudmila KajtmanovaLeos NavratilRadek SedlacekTomas SuchyMeena Jhanwar-UniyalPavla JendelovaLucia Machova UrdzikovaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Barbora Svobodova Anna Kloudova Jiri Ruzicka Ludmila Kajtmanova Leos Navratil Radek Sedlacek Tomas Suchy Meena Jhanwar-Uniyal Pavla Jendelova Lucia Machova Urdzikova The effect of 808 nm and 905 nm wavelength light on recovery after spinal cord injury
description	Abstract We investigated the effect of a Multiwave Locked System laser (with a simultaneous 808 nm continuous emission and 905 nm pulse emission) on the spinal cord after spinal cord injury (SCI) in rats. The functional recovery was measured by locomotor tests (BBB, Beam walking, MotoRater) and a sensitivity test (Plantar test). The locomotor tests showed a significant improvement of the locomotor functions of the rats after laser treatment from the first week following lesioning, compared to the controls. The laser treatment significantly diminished thermal hyperalgesia after SCI as measured by the Plantar test. The atrophy of the soleus muscle was reduced in the laser treated rats. The histopathological investigation showed a positive effect of the laser therapy on white and gray matter sparing. Our data suggests an upregulation of M2 macrophages in laser treated animals by the increasing number of double labeled CD68+/CD206+ cells in the cranial and central parts of the lesion, compared to the control animals. A shift in microglial/macrophage polarization was confirmed by gene expression analysis by significant mRNA downregulation of Cd86 (marker of inflammatory M1), and non-significant upregulation of Arg1 (marker of M2). These results demonstrated that the combination of 808 nm and 905 nm wavelength light is a promising non-invasive therapy for improving functional recovery and tissue sparing after SCI.
format	article
author	Barbora Svobodova Anna Kloudova Jiri Ruzicka Ludmila Kajtmanova Leos Navratil Radek Sedlacek Tomas Suchy Meena Jhanwar-Uniyal Pavla Jendelova Lucia Machova Urdzikova
author_facet	Barbora Svobodova Anna Kloudova Jiri Ruzicka Ludmila Kajtmanova Leos Navratil Radek Sedlacek Tomas Suchy Meena Jhanwar-Uniyal Pavla Jendelova Lucia Machova Urdzikova
author_sort	Barbora Svobodova
title	The effect of 808 nm and 905 nm wavelength light on recovery after spinal cord injury
title_short	The effect of 808 nm and 905 nm wavelength light on recovery after spinal cord injury
title_full	The effect of 808 nm and 905 nm wavelength light on recovery after spinal cord injury
title_fullStr	The effect of 808 nm and 905 nm wavelength light on recovery after spinal cord injury
title_full_unstemmed	The effect of 808 nm and 905 nm wavelength light on recovery after spinal cord injury
title_sort	effect of 808 nm and 905 nm wavelength light on recovery after spinal cord injury
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/74c6f68c594d436b84386b9795b5b6b1
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The effect of 808 nm and 905 nm wavelength light on recovery after spinal cord injury

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