Nicotine delivery and relief of craving after consumption of European JUUL e-cigarettes prior and after pod modification

Abstract The emergence of e-cigarettes on the consumer market led to a tremendous rise in e-cigarette consumption among adolescents in the United States. The success of JUUL and other pod systems was linked to its high nicotine delivery capacity. In compliance with the European Tobacco Product direc...

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Autores principales:	Nadja Mallock, Andrea Rabenstein, Solveig Gernun, Peter Laux, Christoph Hutzler, Susanne Karch, Gabriele Koller, Frank Henkler-Stephani, Maria Kristina Parr, Oliver Pogarell, Andreas Luch, Tobias Rüther
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/74c8724cb1b1475889079af7a3f7830a
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spelling	oai:doaj.org-article:74c8724cb1b1475889079af7a3f7830a2021-12-02T14:58:14ZNicotine delivery and relief of craving after consumption of European JUUL e-cigarettes prior and after pod modification10.1038/s41598-021-91593-62045-2322https://doaj.org/article/74c8724cb1b1475889079af7a3f7830a2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91593-6https://doaj.org/toc/2045-2322Abstract The emergence of e-cigarettes on the consumer market led to a tremendous rise in e-cigarette consumption among adolescents in the United States. The success of JUUL and other pod systems was linked to its high nicotine delivery capacity. In compliance with the European Tobacco Product directive, liquid nicotine contents in the European JUUL variants are limited to 20 mg/mL or below. A short time after launching the initial version in Europe, JUUL pods have been modified in terms of the wick material used. This modification has been demonstrated previously to lead to an elevated aerosol generation, consequently, to a larger amount of nicotine per puff generated. The present study was designed to assess whether the mentioned differences between the “initial” and “modified” JUUL versions may cause a significant difference during consumption, and how nicotine delivery compares with tobacco cigarettes. In this single-center three-arm study, nicotine pharmacokinetics and influence on urge to smoke/vape were compared for tobacco cigarettes, the “initial” version of the European JUUL, and the “modified” version of the European JUUL. Participants, 15 active smokers and 17 active e-cigarette users, were instructed to consume their study product according to a pre-directed puffing protocol. Venous blood was sampled for nicotine analysis to cover the acute phase and the first 30 min after starting. Nicotine delivery and the reduction of urge to smoke/vape upon usage of both European JUUL variants were lower in comparison to tobacco cigarettes. This suggests a lower addictive potential. Modification of the pod design did not result in significant differences at the first ten puffs, as confirmed by a vaping machine experiment. Apparently, the limitations by the initially used wick material only come into effect after longer usage time.Nadja MallockAndrea RabensteinSolveig GernunPeter LauxChristoph HutzlerSusanne KarchGabriele KollerFrank Henkler-StephaniMaria Kristina ParrOliver PogarellAndreas LuchTobias RütherNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nadja Mallock Andrea Rabenstein Solveig Gernun Peter Laux Christoph Hutzler Susanne Karch Gabriele Koller Frank Henkler-Stephani Maria Kristina Parr Oliver Pogarell Andreas Luch Tobias Rüther Nicotine delivery and relief of craving after consumption of European JUUL e-cigarettes prior and after pod modification
description	Abstract The emergence of e-cigarettes on the consumer market led to a tremendous rise in e-cigarette consumption among adolescents in the United States. The success of JUUL and other pod systems was linked to its high nicotine delivery capacity. In compliance with the European Tobacco Product directive, liquid nicotine contents in the European JUUL variants are limited to 20 mg/mL or below. A short time after launching the initial version in Europe, JUUL pods have been modified in terms of the wick material used. This modification has been demonstrated previously to lead to an elevated aerosol generation, consequently, to a larger amount of nicotine per puff generated. The present study was designed to assess whether the mentioned differences between the “initial” and “modified” JUUL versions may cause a significant difference during consumption, and how nicotine delivery compares with tobacco cigarettes. In this single-center three-arm study, nicotine pharmacokinetics and influence on urge to smoke/vape were compared for tobacco cigarettes, the “initial” version of the European JUUL, and the “modified” version of the European JUUL. Participants, 15 active smokers and 17 active e-cigarette users, were instructed to consume their study product according to a pre-directed puffing protocol. Venous blood was sampled for nicotine analysis to cover the acute phase and the first 30 min after starting. Nicotine delivery and the reduction of urge to smoke/vape upon usage of both European JUUL variants were lower in comparison to tobacco cigarettes. This suggests a lower addictive potential. Modification of the pod design did not result in significant differences at the first ten puffs, as confirmed by a vaping machine experiment. Apparently, the limitations by the initially used wick material only come into effect after longer usage time.
format	article
author	Nadja Mallock Andrea Rabenstein Solveig Gernun Peter Laux Christoph Hutzler Susanne Karch Gabriele Koller Frank Henkler-Stephani Maria Kristina Parr Oliver Pogarell Andreas Luch Tobias Rüther
author_facet	Nadja Mallock Andrea Rabenstein Solveig Gernun Peter Laux Christoph Hutzler Susanne Karch Gabriele Koller Frank Henkler-Stephani Maria Kristina Parr Oliver Pogarell Andreas Luch Tobias Rüther
author_sort	Nadja Mallock
title	Nicotine delivery and relief of craving after consumption of European JUUL e-cigarettes prior and after pod modification
title_short	Nicotine delivery and relief of craving after consumption of European JUUL e-cigarettes prior and after pod modification
title_full	Nicotine delivery and relief of craving after consumption of European JUUL e-cigarettes prior and after pod modification
title_fullStr	Nicotine delivery and relief of craving after consumption of European JUUL e-cigarettes prior and after pod modification
title_full_unstemmed	Nicotine delivery and relief of craving after consumption of European JUUL e-cigarettes prior and after pod modification
title_sort	nicotine delivery and relief of craving after consumption of european juul e-cigarettes prior and after pod modification
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/74c8724cb1b1475889079af7a3f7830a
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Nicotine delivery and relief of craving after consumption of European JUUL e-cigarettes prior and after pod modification

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