PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum

Calcium dependent protein kinase 1 (CDPK1) plays an important role in asexual development of Plasmodium falciparum. Using phosphoproteomics and conditional knockdown of CDPK1, the authors here identify CDPK1 substrates and a cross-talk between CDPK1 and PKA, and show the role of CDPK1 in parasite in...

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Autores principales:	Sudhir Kumar, Manish Kumar, Roseleen Ekka, Jeffrey D. Dvorin, Aditya S. Paul, Anil K. Madugundu, Tim Gilberger, Harsha Gowda, Manoj T. Duraisingh, T. S. Keshava Prasad, Pushkar Sharma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/74c94d5ff9f648c2a5538d04ec0915e0
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spelling	oai:doaj.org-article:74c94d5ff9f648c2a5538d04ec0915e02021-12-02T13:23:47ZPfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum10.1038/s41467-017-00053-12041-1723https://doaj.org/article/74c94d5ff9f648c2a5538d04ec0915e02017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00053-1https://doaj.org/toc/2041-1723Calcium dependent protein kinase 1 (CDPK1) plays an important role in asexual development of Plasmodium falciparum. Using phosphoproteomics and conditional knockdown of CDPK1, the authors here identify CDPK1 substrates and a cross-talk between CDPK1 and PKA, and show the role of CDPK1 in parasite invasion.Sudhir KumarManish KumarRoseleen EkkaJeffrey D. DvorinAditya S. PaulAnil K. MadugunduTim GilbergerHarsha GowdaManoj T. DuraisinghT. S. Keshava PrasadPushkar SharmaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sudhir Kumar Manish Kumar Roseleen Ekka Jeffrey D. Dvorin Aditya S. Paul Anil K. Madugundu Tim Gilberger Harsha Gowda Manoj T. Duraisingh T. S. Keshava Prasad Pushkar Sharma PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum
description	Calcium dependent protein kinase 1 (CDPK1) plays an important role in asexual development of Plasmodium falciparum. Using phosphoproteomics and conditional knockdown of CDPK1, the authors here identify CDPK1 substrates and a cross-talk between CDPK1 and PKA, and show the role of CDPK1 in parasite invasion.
format	article
author	Sudhir Kumar Manish Kumar Roseleen Ekka Jeffrey D. Dvorin Aditya S. Paul Anil K. Madugundu Tim Gilberger Harsha Gowda Manoj T. Duraisingh T. S. Keshava Prasad Pushkar Sharma
author_facet	Sudhir Kumar Manish Kumar Roseleen Ekka Jeffrey D. Dvorin Aditya S. Paul Anil K. Madugundu Tim Gilberger Harsha Gowda Manoj T. Duraisingh T. S. Keshava Prasad Pushkar Sharma
author_sort	Sudhir Kumar
title	PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum
title_short	PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum
title_full	PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum
title_fullStr	PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum
title_full_unstemmed	PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum
title_sort	pfcdpk1 mediated signaling in erythrocytic stages of plasmodium falciparum
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/74c94d5ff9f648c2a5538d04ec0915e0
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PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum

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