Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)

Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)

The gut microbiome affects systemic metabolism and is a therapeutic target for type 2 diabetes. Here the authors demonstrate in a randomized controlled trial that effects of berberine, a plant alkaloid known to lower blood glucose, may be explained by the inhibition of Ruminococcus bromii mediated b...

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Autores principales: Yifei Zhang, Yanyun Gu, Huahui Ren, Shujie Wang, Huanzi Zhong, Xinjie Zhao, Jing Ma, Xuejiang Gu, Yaoming Xue, Shan Huang, Jialin Yang, Li Chen, Gang Chen, Shen Qu, Jun Liang, Li Qin, Qin Huang, Yongde Peng, Qi Li, Xiaolin Wang, Ping Kong, Guixue Hou, Mengyu Gao, Zhun Shi, Xuelin Li, Yixuan Qiu, Yuanqiang Zou, Huanming Yang, Jian Wang, Guowang Xu, Shenghan Lai, Junhua Li, Guang Ning, Weiqing Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
Q
Acceso en línea:https://doaj.org/article/74c9d1428bb541f88cc853d5a77532db
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spelling oai:doaj.org-article:74c9d1428bb541f88cc853d5a77532db2021-12-02T18:01:49ZGut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)10.1038/s41467-020-18414-82041-1723https://doaj.org/article/74c9d1428bb541f88cc853d5a77532db2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18414-8https://doaj.org/toc/2041-1723The gut microbiome affects systemic metabolism and is a therapeutic target for type 2 diabetes. Here the authors demonstrate in a randomized controlled trial that effects of berberine, a plant alkaloid known to lower blood glucose, may be explained by the inhibition of Ruminococcus bromii mediated biotransformation of the bile acid deoxycholic acid.Yifei ZhangYanyun GuHuahui RenShujie WangHuanzi ZhongXinjie ZhaoJing MaXuejiang GuYaoming XueShan HuangJialin YangLi ChenGang ChenShen QuJun LiangLi QinQin HuangYongde PengQi LiXiaolin WangPing KongGuixue HouMengyu GaoZhun ShiXuelin LiYixuan QiuYuanqiang ZouHuanming YangJian WangGuowang XuShenghan LaiJunhua LiGuang NingWeiqing WangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yifei Zhang
Yanyun Gu
Huahui Ren
Shujie Wang
Huanzi Zhong
Xinjie Zhao
Jing Ma
Xuejiang Gu
Yaoming Xue
Shan Huang
Jialin Yang
Li Chen
Gang Chen
Shen Qu
Jun Liang
Li Qin
Qin Huang
Yongde Peng
Qi Li
Xiaolin Wang
Ping Kong
Guixue Hou
Mengyu Gao
Zhun Shi
Xuelin Li
Yixuan Qiu
Yuanqiang Zou
Huanming Yang
Jian Wang
Guowang Xu
Shenghan Lai
Junhua Li
Guang Ning
Weiqing Wang
Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)
description The gut microbiome affects systemic metabolism and is a therapeutic target for type 2 diabetes. Here the authors demonstrate in a randomized controlled trial that effects of berberine, a plant alkaloid known to lower blood glucose, may be explained by the inhibition of Ruminococcus bromii mediated biotransformation of the bile acid deoxycholic acid.
format article
author Yifei Zhang
Yanyun Gu
Huahui Ren
Shujie Wang
Huanzi Zhong
Xinjie Zhao
Jing Ma
Xuejiang Gu
Yaoming Xue
Shan Huang
Jialin Yang
Li Chen
Gang Chen
Shen Qu
Jun Liang
Li Qin
Qin Huang
Yongde Peng
Qi Li
Xiaolin Wang
Ping Kong
Guixue Hou
Mengyu Gao
Zhun Shi
Xuelin Li
Yixuan Qiu
Yuanqiang Zou
Huanming Yang
Jian Wang
Guowang Xu
Shenghan Lai
Junhua Li
Guang Ning
Weiqing Wang
author_facet Yifei Zhang
Yanyun Gu
Huahui Ren
Shujie Wang
Huanzi Zhong
Xinjie Zhao
Jing Ma
Xuejiang Gu
Yaoming Xue
Shan Huang
Jialin Yang
Li Chen
Gang Chen
Shen Qu
Jun Liang
Li Qin
Qin Huang
Yongde Peng
Qi Li
Xiaolin Wang
Ping Kong
Guixue Hou
Mengyu Gao
Zhun Shi
Xuelin Li
Yixuan Qiu
Yuanqiang Zou
Huanming Yang
Jian Wang
Guowang Xu
Shenghan Lai
Junhua Li
Guang Ning
Weiqing Wang
author_sort Yifei Zhang
title Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)
title_short Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)
title_full Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)
title_fullStr Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)
title_full_unstemmed Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)
title_sort gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the premote study)
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/74c9d1428bb541f88cc853d5a77532db
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