Safety, infectivity and immunogenicity of a genetically attenuated blood-stage malaria vaccine

Safety, infectivity and immunogenicity of a genetically attenuated blood-stage malaria vaccine

Abstract Background There is a clear need for novel approaches to malaria vaccine development. We aimed to develop a genetically attenuated blood-stage vaccine and test its safety, infectivity, and immunogenicity in healthy volunteers. Our approach was to target the gene encoding the knob-associated...

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Autores principales: Rebecca Webster, Silvana Sekuloski, Anand Odedra, Stephen Woolley, Helen Jennings, Fiona Amante, Katharine R. Trenholme, Julie Healer, Alan F. Cowman, Emily M. Eriksson, Priyanka Sathe, Jocelyn Penington, Adam J. Blanch, Matthew W. A. Dixon, Leann Tilley, Michael F. Duffy, Alister Craig, Janet Storm, Jo-Anne Chan, Krystal Evans, Anthony T. Papenfuss, Louis Schofield, Paul Griffin, Bridget E. Barber, Dean Andrew, Michelle J. Boyle, Fabian de Labastida Rivera, Christian Engwerda, James S. McCarthy
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
Malaria
Vaccine
Plasmodium falciparum
Genetically attenuated
KAHRP
PfEMP1
Medicine
R
Acceso en línea:https://doaj.org/article/74cfc9b904474091b17850c1e5910004
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