Specific human cytomegalovirus signature detected in NK cell metabolic changes post vaccination

Abstract Effective vaccines for human immunodeficiency virus-1 (HIV-1) and hepatitis C virus (HCV) remain a significant challenge for these infectious diseases. Given that the innate immune response is key to controlling the scale and nature of developing adaptive immune responses, targeting natural...

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Autores principales:	Elena Woods, Vanessa Zaiatz-Bittencourt, Ciaran Bannan, Colm Bergin, David K. Finlay, Matthias Hoffmann, Anthony Brown, Bethany Turner, Shokouh Makvandi-Nejad, Ventzi Vassilev, Stefania Capone, Antonella Folgori, Tomáš Hanke, Eleanor Barnes, Lucy Dorrell, Clair M. Gardiner, PEACHI Consortium
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/74d0067fe0754a63bf1b9631ac60ca73
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spelling	oai:doaj.org-article:74d0067fe0754a63bf1b9631ac60ca732021-12-02T18:51:05ZSpecific human cytomegalovirus signature detected in NK cell metabolic changes post vaccination10.1038/s41541-021-00381-w2059-0105https://doaj.org/article/74d0067fe0754a63bf1b9631ac60ca732021-09-01T00:00:00Zhttps://doi.org/10.1038/s41541-021-00381-whttps://doaj.org/toc/2059-0105Abstract Effective vaccines for human immunodeficiency virus-1 (HIV-1) and hepatitis C virus (HCV) remain a significant challenge for these infectious diseases. Given that the innate immune response is key to controlling the scale and nature of developing adaptive immune responses, targeting natural killer (NK) cells that can promote a T-helper type 1 (Th1)-type immune response through the production of interferon-γ (IFNγ) remains an untapped strategic target for improved vaccination approaches. Here, we investigate metabolic and functional responses of NK cells to simian adenovirus prime and MVA boost vaccination in a cohort of healthy volunteers receiving a dual HCV-HIV-1 vaccine. Early and late timepoints demonstrated metabolic changes that contributed to the sustained proliferation of all NK cells. However, a strong impact of human cytomegalovirus (HCMV) on some metabolic and functional responses in NK cells was observed in HCMV seropositive participants. These changes were not restricted to molecularly defined adaptive NK cells; indeed, canonical NK cells that produced most IFNγ in response to vaccination were equally impacted in individuals with latent HCMV. In summary, NK cells undergo metabolic changes in response to vaccination, and understanding these in the context of HCMV is an important step towards rational vaccine design against a range of human viral pathogens.Elena WoodsVanessa Zaiatz-BittencourtCiaran BannanColm BerginDavid K. FinlayMatthias HoffmannAnthony BrownBethany TurnerShokouh Makvandi-NejadVentzi VassilevStefania CaponeAntonella FolgoriTomáš HankeEleanor BarnesLucy DorrellClair M. GardinerPEACHI ConsortiumNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 6, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Elena Woods Vanessa Zaiatz-Bittencourt Ciaran Bannan Colm Bergin David K. Finlay Matthias Hoffmann Anthony Brown Bethany Turner Shokouh Makvandi-Nejad Ventzi Vassilev Stefania Capone Antonella Folgori Tomáš Hanke Eleanor Barnes Lucy Dorrell Clair M. Gardiner PEACHI Consortium Specific human cytomegalovirus signature detected in NK cell metabolic changes post vaccination
description	Abstract Effective vaccines for human immunodeficiency virus-1 (HIV-1) and hepatitis C virus (HCV) remain a significant challenge for these infectious diseases. Given that the innate immune response is key to controlling the scale and nature of developing adaptive immune responses, targeting natural killer (NK) cells that can promote a T-helper type 1 (Th1)-type immune response through the production of interferon-γ (IFNγ) remains an untapped strategic target for improved vaccination approaches. Here, we investigate metabolic and functional responses of NK cells to simian adenovirus prime and MVA boost vaccination in a cohort of healthy volunteers receiving a dual HCV-HIV-1 vaccine. Early and late timepoints demonstrated metabolic changes that contributed to the sustained proliferation of all NK cells. However, a strong impact of human cytomegalovirus (HCMV) on some metabolic and functional responses in NK cells was observed in HCMV seropositive participants. These changes were not restricted to molecularly defined adaptive NK cells; indeed, canonical NK cells that produced most IFNγ in response to vaccination were equally impacted in individuals with latent HCMV. In summary, NK cells undergo metabolic changes in response to vaccination, and understanding these in the context of HCMV is an important step towards rational vaccine design against a range of human viral pathogens.
format	article
author	Elena Woods Vanessa Zaiatz-Bittencourt Ciaran Bannan Colm Bergin David K. Finlay Matthias Hoffmann Anthony Brown Bethany Turner Shokouh Makvandi-Nejad Ventzi Vassilev Stefania Capone Antonella Folgori Tomáš Hanke Eleanor Barnes Lucy Dorrell Clair M. Gardiner PEACHI Consortium
author_facet	Elena Woods Vanessa Zaiatz-Bittencourt Ciaran Bannan Colm Bergin David K. Finlay Matthias Hoffmann Anthony Brown Bethany Turner Shokouh Makvandi-Nejad Ventzi Vassilev Stefania Capone Antonella Folgori Tomáš Hanke Eleanor Barnes Lucy Dorrell Clair M. Gardiner PEACHI Consortium
author_sort	Elena Woods
title	Specific human cytomegalovirus signature detected in NK cell metabolic changes post vaccination
title_short	Specific human cytomegalovirus signature detected in NK cell metabolic changes post vaccination
title_full	Specific human cytomegalovirus signature detected in NK cell metabolic changes post vaccination
title_fullStr	Specific human cytomegalovirus signature detected in NK cell metabolic changes post vaccination
title_full_unstemmed	Specific human cytomegalovirus signature detected in NK cell metabolic changes post vaccination
title_sort	specific human cytomegalovirus signature detected in nk cell metabolic changes post vaccination
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/74d0067fe0754a63bf1b9631ac60ca73
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Specific human cytomegalovirus signature detected in NK cell metabolic changes post vaccination

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