Regulatory Functions of Protein Tyrosine Phosphatase Receptor Type O in Immune Cells

The members of the protein tyrosine phosphatase (PTP) family are key regulators in multiple signal transduction pathways and therefore they play important roles in many cellular processes, including immune response. As a member of PTP family, protein tyrosine phosphatase receptor type O (PTPRO) belo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Feiling Xie, Hongmei Dong, Hao Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	protein tyrosine phosphatases PTPRO PTPROt B cells T cells macrophages Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/74d2970a8fd44e8c83912c2ceadb8171
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:74d2970a8fd44e8c83912c2ceadb8171
record_format	dspace
spelling	oai:doaj.org-article:74d2970a8fd44e8c83912c2ceadb81712021-11-22T06:33:15ZRegulatory Functions of Protein Tyrosine Phosphatase Receptor Type O in Immune Cells1664-322410.3389/fimmu.2021.783370https://doaj.org/article/74d2970a8fd44e8c83912c2ceadb81712021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.783370/fullhttps://doaj.org/toc/1664-3224The members of the protein tyrosine phosphatase (PTP) family are key regulators in multiple signal transduction pathways and therefore they play important roles in many cellular processes, including immune response. As a member of PTP family, protein tyrosine phosphatase receptor type O (PTPRO) belongs to the R3 receptor-like protein tyrosine phosphatases. The expression of PTPRO isoforms is tissue-specific and the truncated PTPRO (PTPROt) is mainly observed in hematopoietic cells, including B cells, T cells, macrophages and other immune cells. Therefore, PTPROt may play an important role in immune cells by affecting their growth, differentiation, activation and immune responses. In this review, we will focus on the regulatory roles and underlying molecular mechanisms of PTPRO/PTPROt in immune cells, including B cells, T cells, and macrophages.Feiling XieFeiling XieHongmei DongHongmei DongHao ZhangHao ZhangHao ZhangHao ZhangFrontiers Media S.A.articleprotein tyrosine phosphatasesPTPROPTPROtB cellsT cellsmacrophagesImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	protein tyrosine phosphatases PTPRO PTPROt B cells T cells macrophages Immunologic diseases. Allergy RC581-607
spellingShingle	protein tyrosine phosphatases PTPRO PTPROt B cells T cells macrophages Immunologic diseases. Allergy RC581-607 Feiling Xie Feiling Xie Hongmei Dong Hongmei Dong Hao Zhang Hao Zhang Hao Zhang Hao Zhang Regulatory Functions of Protein Tyrosine Phosphatase Receptor Type O in Immune Cells
description	The members of the protein tyrosine phosphatase (PTP) family are key regulators in multiple signal transduction pathways and therefore they play important roles in many cellular processes, including immune response. As a member of PTP family, protein tyrosine phosphatase receptor type O (PTPRO) belongs to the R3 receptor-like protein tyrosine phosphatases. The expression of PTPRO isoforms is tissue-specific and the truncated PTPRO (PTPROt) is mainly observed in hematopoietic cells, including B cells, T cells, macrophages and other immune cells. Therefore, PTPROt may play an important role in immune cells by affecting their growth, differentiation, activation and immune responses. In this review, we will focus on the regulatory roles and underlying molecular mechanisms of PTPRO/PTPROt in immune cells, including B cells, T cells, and macrophages.
format	article
author	Feiling Xie Feiling Xie Hongmei Dong Hongmei Dong Hao Zhang Hao Zhang Hao Zhang Hao Zhang
author_facet	Feiling Xie Feiling Xie Hongmei Dong Hongmei Dong Hao Zhang Hao Zhang Hao Zhang Hao Zhang
author_sort	Feiling Xie
title	Regulatory Functions of Protein Tyrosine Phosphatase Receptor Type O in Immune Cells
title_short	Regulatory Functions of Protein Tyrosine Phosphatase Receptor Type O in Immune Cells
title_full	Regulatory Functions of Protein Tyrosine Phosphatase Receptor Type O in Immune Cells
title_fullStr	Regulatory Functions of Protein Tyrosine Phosphatase Receptor Type O in Immune Cells
title_full_unstemmed	Regulatory Functions of Protein Tyrosine Phosphatase Receptor Type O in Immune Cells
title_sort	regulatory functions of protein tyrosine phosphatase receptor type o in immune cells
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/74d2970a8fd44e8c83912c2ceadb8171
work_keys_str_mv	AT feilingxie regulatoryfunctionsofproteintyrosinephosphatasereceptortypeoinimmunecells AT feilingxie regulatoryfunctionsofproteintyrosinephosphatasereceptortypeoinimmunecells AT hongmeidong regulatoryfunctionsofproteintyrosinephosphatasereceptortypeoinimmunecells AT hongmeidong regulatoryfunctionsofproteintyrosinephosphatasereceptortypeoinimmunecells AT haozhang regulatoryfunctionsofproteintyrosinephosphatasereceptortypeoinimmunecells AT haozhang regulatoryfunctionsofproteintyrosinephosphatasereceptortypeoinimmunecells AT haozhang regulatoryfunctionsofproteintyrosinephosphatasereceptortypeoinimmunecells AT haozhang regulatoryfunctionsofproteintyrosinephosphatasereceptortypeoinimmunecells
_version_	1718418110647631872

Regulatory Functions of Protein Tyrosine Phosphatase Receptor Type O in Immune Cells

Ejemplares similares