A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy
Ubiquitin (Ub)-mediated xenophagy is important in defense against Mycobacterium tuberculosis (Mtb). Here, Chai et al. describe autophagy triggering by Ub binding to the Mtb surface protein Rv1468c, and show that its deletion leads to increased bacterial loads and hyperinflammatory responses in mice.
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| Lenguaje: | EN |
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Nature Portfolio
2019
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| Acceso en línea: | https://doaj.org/article/74d2a3ea423348b2880c9a031a9391b8 |
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oai:doaj.org-article:74d2a3ea423348b2880c9a031a9391b82021-12-02T14:40:19ZA Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy10.1038/s41467-019-09955-82041-1723https://doaj.org/article/74d2a3ea423348b2880c9a031a9391b82019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09955-8https://doaj.org/toc/2041-1723Ubiquitin (Ub)-mediated xenophagy is important in defense against Mycobacterium tuberculosis (Mtb). Here, Chai et al. describe autophagy triggering by Ub binding to the Mtb surface protein Rv1468c, and show that its deletion leads to increased bacterial loads and hyperinflammatory responses in mice.Qiyao ChaiXudong WangLihua QiangYong ZhangPupu GeZhe LuYanzhao ZhongBingxi LiJing WangLingqiang ZhangDawang ZhouWei LiWenzhu DongYu PangGeorge Fu GaoCui Hua LiuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Qiyao Chai Xudong Wang Lihua Qiang Yong Zhang Pupu Ge Zhe Lu Yanzhao Zhong Bingxi Li Jing Wang Lingqiang Zhang Dawang Zhou Wei Li Wenzhu Dong Yu Pang George Fu Gao Cui Hua Liu A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy |
| description |
Ubiquitin (Ub)-mediated xenophagy is important in defense against Mycobacterium tuberculosis (Mtb). Here, Chai et al. describe autophagy triggering by Ub binding to the Mtb surface protein Rv1468c, and show that its deletion leads to increased bacterial loads and hyperinflammatory responses in mice. |
| format |
article |
| author |
Qiyao Chai Xudong Wang Lihua Qiang Yong Zhang Pupu Ge Zhe Lu Yanzhao Zhong Bingxi Li Jing Wang Lingqiang Zhang Dawang Zhou Wei Li Wenzhu Dong Yu Pang George Fu Gao Cui Hua Liu |
| author_facet |
Qiyao Chai Xudong Wang Lihua Qiang Yong Zhang Pupu Ge Zhe Lu Yanzhao Zhong Bingxi Li Jing Wang Lingqiang Zhang Dawang Zhou Wei Li Wenzhu Dong Yu Pang George Fu Gao Cui Hua Liu |
| author_sort |
Qiyao Chai |
| title |
A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy |
| title_short |
A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy |
| title_full |
A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy |
| title_fullStr |
A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy |
| title_full_unstemmed |
A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy |
| title_sort |
mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/74d2a3ea423348b2880c9a031a9391b8 |
| work_keys_str_mv |
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