High-throughput behavioral screen in C. elegans reveals Parkinson’s disease drug candidates

Salman Sohrabi et al. develop an automated, high-throughput assay to study spasm-like curling behavior in C. elegans, which is related to motor control symptoms in Parkinson’s disease. They apply this screening approach to identify four candidate drugs for potential late-in-life interventions for Pa...

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Autores principales: Salman Sohrabi, Danielle E. Mor, Rachel Kaletsky, William Keyes, Coleen T. Murphy
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/74da37c3af4d4181ad273528c6947316
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Sumario:Salman Sohrabi et al. develop an automated, high-throughput assay to study spasm-like curling behavior in C. elegans, which is related to motor control symptoms in Parkinson’s disease. They apply this screening approach to identify four candidate drugs for potential late-in-life interventions for Parkinson’s disease.