High-throughput behavioral screen in C. elegans reveals Parkinson’s disease drug candidates

Salman Sohrabi et al. develop an automated, high-throughput assay to study spasm-like curling behavior in C. elegans, which is related to motor control symptoms in Parkinson’s disease. They apply this screening approach to identify four candidate drugs for potential late-in-life interventions for Pa...

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Autores principales:	Salman Sohrabi, Danielle E. Mor, Rachel Kaletsky, William Keyes, Coleen T. Murphy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/74da37c3af4d4181ad273528c6947316
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spelling	oai:doaj.org-article:74da37c3af4d4181ad273528c69473162021-12-02T14:21:58ZHigh-throughput behavioral screen in C. elegans reveals Parkinson’s disease drug candidates10.1038/s42003-021-01731-z2399-3642https://doaj.org/article/74da37c3af4d4181ad273528c69473162021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01731-zhttps://doaj.org/toc/2399-3642Salman Sohrabi et al. develop an automated, high-throughput assay to study spasm-like curling behavior in C. elegans, which is related to motor control symptoms in Parkinson’s disease. They apply this screening approach to identify four candidate drugs for potential late-in-life interventions for Parkinson’s disease.Salman SohrabiDanielle E. MorRachel KaletskyWilliam KeyesColeen T. MurphyNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Salman Sohrabi Danielle E. Mor Rachel Kaletsky William Keyes Coleen T. Murphy High-throughput behavioral screen in C. elegans reveals Parkinson’s disease drug candidates
description	Salman Sohrabi et al. develop an automated, high-throughput assay to study spasm-like curling behavior in C. elegans, which is related to motor control symptoms in Parkinson’s disease. They apply this screening approach to identify four candidate drugs for potential late-in-life interventions for Parkinson’s disease.
format	article
author	Salman Sohrabi Danielle E. Mor Rachel Kaletsky William Keyes Coleen T. Murphy
author_facet	Salman Sohrabi Danielle E. Mor Rachel Kaletsky William Keyes Coleen T. Murphy
author_sort	Salman Sohrabi
title	High-throughput behavioral screen in C. elegans reveals Parkinson’s disease drug candidates
title_short	High-throughput behavioral screen in C. elegans reveals Parkinson’s disease drug candidates
title_full	High-throughput behavioral screen in C. elegans reveals Parkinson’s disease drug candidates
title_fullStr	High-throughput behavioral screen in C. elegans reveals Parkinson’s disease drug candidates
title_full_unstemmed	High-throughput behavioral screen in C. elegans reveals Parkinson’s disease drug candidates
title_sort	high-throughput behavioral screen in c. elegans reveals parkinson’s disease drug candidates
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/74da37c3af4d4181ad273528c6947316
work_keys_str_mv	AT salmansohrabi highthroughputbehavioralscreenincelegansrevealsparkinsonsdiseasedrugcandidates AT danielleemor highthroughputbehavioralscreenincelegansrevealsparkinsonsdiseasedrugcandidates AT rachelkaletsky highthroughputbehavioralscreenincelegansrevealsparkinsonsdiseasedrugcandidates AT williamkeyes highthroughputbehavioralscreenincelegansrevealsparkinsonsdiseasedrugcandidates AT coleentmurphy highthroughputbehavioralscreenincelegansrevealsparkinsonsdiseasedrugcandidates
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High-throughput behavioral screen in C. elegans reveals Parkinson’s disease drug candidates

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