Homologous laminar organization of the mouse and human subiculum

Abstract The subiculum is the major output component of the hippocampal formation and one of the major brain structures most affected by Alzheimer’s disease. Our previous work revealed a hidden laminar architecture within the mouse subiculum. However, the rotation of the hippocampal longitudinal axi...

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Autores principales:	Michael S. Bienkowski, Farshid Sepehrband, Nyoman D. Kurniawan, Jim Stanis, Laura Korobkova, Neda Khanjani, Kristi Clark, Houri Hintiryan, Carol A. Miller, Hong-Wei Dong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/74db091c0701444b8d9ea4ad6e4f2329
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spelling	oai:doaj.org-article:74db091c0701444b8d9ea4ad6e4f23292021-12-02T13:30:17ZHomologous laminar organization of the mouse and human subiculum10.1038/s41598-021-81362-w2045-2322https://doaj.org/article/74db091c0701444b8d9ea4ad6e4f23292021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81362-whttps://doaj.org/toc/2045-2322Abstract The subiculum is the major output component of the hippocampal formation and one of the major brain structures most affected by Alzheimer’s disease. Our previous work revealed a hidden laminar architecture within the mouse subiculum. However, the rotation of the hippocampal longitudinal axis across species makes it unclear how the laminar organization is represented in human subiculum. Using in situ hybridization data from the Allen Human Brain Atlas, we demonstrate that the human subiculum also contains complementary laminar gene expression patterns similar to the mouse. In addition, we provide evidence that the molecular domain boundaries in human subiculum correspond to microstructural differences observed in high resolution MRI and fiber density imaging. Finally, we show both similarities and differences in the gene expression profile of subiculum pyramidal cells within homologous lamina. Overall, we present a new 3D model of the anatomical organization of human subiculum and its evolution from the mouse.Michael S. BienkowskiFarshid SepehrbandNyoman D. KurniawanJim StanisLaura KorobkovaNeda KhanjaniKristi ClarkHouri HintiryanCarol A. MillerHong-Wei DongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michael S. Bienkowski Farshid Sepehrband Nyoman D. Kurniawan Jim Stanis Laura Korobkova Neda Khanjani Kristi Clark Houri Hintiryan Carol A. Miller Hong-Wei Dong Homologous laminar organization of the mouse and human subiculum
description	Abstract The subiculum is the major output component of the hippocampal formation and one of the major brain structures most affected by Alzheimer’s disease. Our previous work revealed a hidden laminar architecture within the mouse subiculum. However, the rotation of the hippocampal longitudinal axis across species makes it unclear how the laminar organization is represented in human subiculum. Using in situ hybridization data from the Allen Human Brain Atlas, we demonstrate that the human subiculum also contains complementary laminar gene expression patterns similar to the mouse. In addition, we provide evidence that the molecular domain boundaries in human subiculum correspond to microstructural differences observed in high resolution MRI and fiber density imaging. Finally, we show both similarities and differences in the gene expression profile of subiculum pyramidal cells within homologous lamina. Overall, we present a new 3D model of the anatomical organization of human subiculum and its evolution from the mouse.
format	article
author	Michael S. Bienkowski Farshid Sepehrband Nyoman D. Kurniawan Jim Stanis Laura Korobkova Neda Khanjani Kristi Clark Houri Hintiryan Carol A. Miller Hong-Wei Dong
author_facet	Michael S. Bienkowski Farshid Sepehrband Nyoman D. Kurniawan Jim Stanis Laura Korobkova Neda Khanjani Kristi Clark Houri Hintiryan Carol A. Miller Hong-Wei Dong
author_sort	Michael S. Bienkowski
title	Homologous laminar organization of the mouse and human subiculum
title_short	Homologous laminar organization of the mouse and human subiculum
title_full	Homologous laminar organization of the mouse and human subiculum
title_fullStr	Homologous laminar organization of the mouse and human subiculum
title_full_unstemmed	Homologous laminar organization of the mouse and human subiculum
title_sort	homologous laminar organization of the mouse and human subiculum
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/74db091c0701444b8d9ea4ad6e4f2329
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Homologous laminar organization of the mouse and human subiculum

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