The Potential Use of Aptamers in The Process of Drug Development

Single-stranded nucleic acids can fold and create unique 3-dimensional structures when interacting with other molecules. The unique structure can achieve high specificity and affinity for the particular target. Synthetic oligonucleotide binding agents, also known as aptamers, are generated through t...

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Autores principales:	Tooba Gholikhani, Balam Jimenez Brito, Frey Livingston, Shalen Kumar
Formato:	article
Lenguaje:	EN
Publicado:	Tabriz University of Medical Sciences 2021
Materias:	aptamers drug discovery selex review drug development Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/74de1c6a52444bdcbe5e985b869311ff
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spelling	oai:doaj.org-article:74de1c6a52444bdcbe5e985b869311ff2021-11-29T05:52:21ZThe Potential Use of Aptamers in The Process of Drug Development2383-288610.34172/PS.2021.17https://doaj.org/article/74de1c6a52444bdcbe5e985b869311ff2021-12-01T00:00:00Zhttps://ps.tbzmed.ac.ir/PDF/ps-27-503.pdfhttps://doaj.org/toc/2383-2886Single-stranded nucleic acids can fold and create unique 3-dimensional structures when interacting with other molecules. The unique structure can achieve high specificity and affinity for the particular target. Synthetic oligonucleotide binding agents, also known as aptamers, are generated through the rational process of Systematic Evolution of Ligands by Exponential Enrichment (SELEX). As this technology matures, it shows increasing promise for use in the field of therapeutic drugs, drug discovery, development, and delivery, and this report seeks to detail how this technology may be applied.Tooba GholikhaniBalam Jimenez BritoFrey LivingstonShalen KumarTabriz University of Medical Sciencesarticleaptamersdrug discoveryselexreviewdrug developmentPharmacy and materia medicaRS1-441ENPharmaceutical Sciences, Vol 27, Iss 4, Pp 503-510 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aptamers drug discovery selex review drug development Pharmacy and materia medica RS1-441
spellingShingle	aptamers drug discovery selex review drug development Pharmacy and materia medica RS1-441 Tooba Gholikhani Balam Jimenez Brito Frey Livingston Shalen Kumar The Potential Use of Aptamers in The Process of Drug Development
description	Single-stranded nucleic acids can fold and create unique 3-dimensional structures when interacting with other molecules. The unique structure can achieve high specificity and affinity for the particular target. Synthetic oligonucleotide binding agents, also known as aptamers, are generated through the rational process of Systematic Evolution of Ligands by Exponential Enrichment (SELEX). As this technology matures, it shows increasing promise for use in the field of therapeutic drugs, drug discovery, development, and delivery, and this report seeks to detail how this technology may be applied.
format	article
author	Tooba Gholikhani Balam Jimenez Brito Frey Livingston Shalen Kumar
author_facet	Tooba Gholikhani Balam Jimenez Brito Frey Livingston Shalen Kumar
author_sort	Tooba Gholikhani
title	The Potential Use of Aptamers in The Process of Drug Development
title_short	The Potential Use of Aptamers in The Process of Drug Development
title_full	The Potential Use of Aptamers in The Process of Drug Development
title_fullStr	The Potential Use of Aptamers in The Process of Drug Development
title_full_unstemmed	The Potential Use of Aptamers in The Process of Drug Development
title_sort	potential use of aptamers in the process of drug development
publisher	Tabriz University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/74de1c6a52444bdcbe5e985b869311ff
work_keys_str_mv	AT toobagholikhani thepotentialuseofaptamersintheprocessofdrugdevelopment AT balamjimenezbrito thepotentialuseofaptamersintheprocessofdrugdevelopment AT freylivingston thepotentialuseofaptamersintheprocessofdrugdevelopment AT shalenkumar thepotentialuseofaptamersintheprocessofdrugdevelopment AT toobagholikhani potentialuseofaptamersintheprocessofdrugdevelopment AT balamjimenezbrito potentialuseofaptamersintheprocessofdrugdevelopment AT freylivingston potentialuseofaptamersintheprocessofdrugdevelopment AT shalenkumar potentialuseofaptamersintheprocessofdrugdevelopment
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The Potential Use of Aptamers in The Process of Drug Development

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