Mechanosensitive Piezo1 Channel Evoked-Mechanical Signals in Atherosclerosis

Shafiu A Umar Shinge, 1 Daifang Zhang, 1, 2 Tobias Achu Muluh, 3 Yongmei Nie, 1, 4 Fengxu Yu 1, 4 1Cardiovascular Surgery Department, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 2Clinical Research Center, Affiliated Hospital of Southw...

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Autores principales:	Shinge SAU, Zhang D, Achu Muluh T, Nie Y, Yu F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	atherogenesis piezo1 channel endothelial cell inflammation shear stress mechanotransduction Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/74e21cc696614f8397008ec2a8a3d04d
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spelling	oai:doaj.org-article:74e21cc696614f8397008ec2a8a3d04d2021-12-02T14:49:53ZMechanosensitive Piezo1 Channel Evoked-Mechanical Signals in Atherosclerosis1178-7031https://doaj.org/article/74e21cc696614f8397008ec2a8a3d04d2021-07-01T00:00:00Zhttps://www.dovepress.com/mechanosensitive-piezo1-channel-evoked-mechanical-signals-in-atheroscl-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Shafiu A Umar Shinge, 1 Daifang Zhang, 1, 2 Tobias Achu Muluh, 3 Yongmei Nie, 1, 4 Fengxu Yu 1, 4 1Cardiovascular Surgery Department, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 2Clinical Research Center, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 3Oncology Department, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 4Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Southwest Medical University, Luzhou, Sichuan, People’s Republic of ChinaCorrespondence: Yongmei Nie; Fengxu Yu Tel +8619938597025; +8613980259707 Email nieyongmei@126.com; yuluchuan@163.comAbstract: Recently, more and more works have focused and used extensive resources on atherosclerosis research, which is one of the major causes of death globally. Alongside traditional risk factors, such as hyperlipidemia, smoking, hypertension, obesity, and diabetes, mechanical forces, including shear stress, pressure and stretches exerted on endothelial cells by flow, is proved to be crucial in atherosclerosis development. Studies have recognized the mechanosensitive Piezo1 channel as a special sensor and transducer of various mechanical forces into biochemical signals, and recent studies report its role in atherosclerosis through different mechanical forces in pressure, stretching and turbulent shear stress. Based on our expertise in this field and considering the recent advancement of atherosclerosis research, we will be focusing on the function of Piezo1 and its involvement in various cellular mechanisms and consequent involvement in the development of atherosclerosis in this review. Also, we will discuss various functions of Piezo1 involvement in atherosclerosis and come up with new mechanistic insight for future research. Based on the recent findings, we suggest Piezo1 as a valid candidate for novel therapeutic innovations, in which deep exploration and translating its findings into the clinic will be a new therapeutic strategy for cardiovascular diseases, particularly atherosclerosis.Keywords: atherogenesis, Piezo1 channel, endothelial cell, inflammation, shear stress, mechanotransductionShinge SAUZhang DAchu Muluh TNie YYu FDove Medical Pressarticleatherogenesispiezo1 channelendothelial cellinflammationshear stressmechanotransductionPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 3621-3636 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atherogenesis piezo1 channel endothelial cell inflammation shear stress mechanotransduction Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	atherogenesis piezo1 channel endothelial cell inflammation shear stress mechanotransduction Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Shinge SAU Zhang D Achu Muluh T Nie Y Yu F Mechanosensitive Piezo1 Channel Evoked-Mechanical Signals in Atherosclerosis
description	Shafiu A Umar Shinge, 1 Daifang Zhang, 1, 2 Tobias Achu Muluh, 3 Yongmei Nie, 1, 4 Fengxu Yu 1, 4 1Cardiovascular Surgery Department, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 2Clinical Research Center, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 3Oncology Department, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 4Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Southwest Medical University, Luzhou, Sichuan, People’s Republic of ChinaCorrespondence: Yongmei Nie; Fengxu Yu Tel +8619938597025; +8613980259707 Email nieyongmei@126.com; yuluchuan@163.comAbstract: Recently, more and more works have focused and used extensive resources on atherosclerosis research, which is one of the major causes of death globally. Alongside traditional risk factors, such as hyperlipidemia, smoking, hypertension, obesity, and diabetes, mechanical forces, including shear stress, pressure and stretches exerted on endothelial cells by flow, is proved to be crucial in atherosclerosis development. Studies have recognized the mechanosensitive Piezo1 channel as a special sensor and transducer of various mechanical forces into biochemical signals, and recent studies report its role in atherosclerosis through different mechanical forces in pressure, stretching and turbulent shear stress. Based on our expertise in this field and considering the recent advancement of atherosclerosis research, we will be focusing on the function of Piezo1 and its involvement in various cellular mechanisms and consequent involvement in the development of atherosclerosis in this review. Also, we will discuss various functions of Piezo1 involvement in atherosclerosis and come up with new mechanistic insight for future research. Based on the recent findings, we suggest Piezo1 as a valid candidate for novel therapeutic innovations, in which deep exploration and translating its findings into the clinic will be a new therapeutic strategy for cardiovascular diseases, particularly atherosclerosis.Keywords: atherogenesis, Piezo1 channel, endothelial cell, inflammation, shear stress, mechanotransduction
format	article
author	Shinge SAU Zhang D Achu Muluh T Nie Y Yu F
author_facet	Shinge SAU Zhang D Achu Muluh T Nie Y Yu F
author_sort	Shinge SAU
title	Mechanosensitive Piezo1 Channel Evoked-Mechanical Signals in Atherosclerosis
title_short	Mechanosensitive Piezo1 Channel Evoked-Mechanical Signals in Atherosclerosis
title_full	Mechanosensitive Piezo1 Channel Evoked-Mechanical Signals in Atherosclerosis
title_fullStr	Mechanosensitive Piezo1 Channel Evoked-Mechanical Signals in Atherosclerosis
title_full_unstemmed	Mechanosensitive Piezo1 Channel Evoked-Mechanical Signals in Atherosclerosis
title_sort	mechanosensitive piezo1 channel evoked-mechanical signals in atherosclerosis
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/74e21cc696614f8397008ec2a8a3d04d
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Mechanosensitive Piezo1 Channel Evoked-Mechanical Signals in Atherosclerosis

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