Two-component latency distributions indicate two-step vesicular release at simple glutamatergic synapses

Traditionally, synaptic release latency has been viewed as constant. Here, at parallel fiber-interneuron synapses, authors see that with sustained release emerges a slow component of increased latencies, which can be simulated with a 2-step model comprised of vesicle docking followed by release.

Guardado en:

Detalles Bibliográficos
Autores principales:	Takafumi Miki, Yukihiro Nakamura, Gerardo Malagon, Erwin Neher, Alain Marty
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/74ed8df94cbc4fd0a111f0e6a354cd32
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:74ed8df94cbc4fd0a111f0e6a354cd32
record_format	dspace
spelling	oai:doaj.org-article:74ed8df94cbc4fd0a111f0e6a354cd322021-12-02T16:49:37ZTwo-component latency distributions indicate two-step vesicular release at simple glutamatergic synapses10.1038/s41467-018-06336-52041-1723https://doaj.org/article/74ed8df94cbc4fd0a111f0e6a354cd322018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06336-5https://doaj.org/toc/2041-1723Traditionally, synaptic release latency has been viewed as constant. Here, at parallel fiber-interneuron synapses, authors see that with sustained release emerges a slow component of increased latencies, which can be simulated with a 2-step model comprised of vesicle docking followed by release.Takafumi MikiYukihiro NakamuraGerardo MalagonErwin NeherAlain MartyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Takafumi Miki Yukihiro Nakamura Gerardo Malagon Erwin Neher Alain Marty Two-component latency distributions indicate two-step vesicular release at simple glutamatergic synapses
description	Traditionally, synaptic release latency has been viewed as constant. Here, at parallel fiber-interneuron synapses, authors see that with sustained release emerges a slow component of increased latencies, which can be simulated with a 2-step model comprised of vesicle docking followed by release.
format	article
author	Takafumi Miki Yukihiro Nakamura Gerardo Malagon Erwin Neher Alain Marty
author_facet	Takafumi Miki Yukihiro Nakamura Gerardo Malagon Erwin Neher Alain Marty
author_sort	Takafumi Miki
title	Two-component latency distributions indicate two-step vesicular release at simple glutamatergic synapses
title_short	Two-component latency distributions indicate two-step vesicular release at simple glutamatergic synapses
title_full	Two-component latency distributions indicate two-step vesicular release at simple glutamatergic synapses
title_fullStr	Two-component latency distributions indicate two-step vesicular release at simple glutamatergic synapses
title_full_unstemmed	Two-component latency distributions indicate two-step vesicular release at simple glutamatergic synapses
title_sort	two-component latency distributions indicate two-step vesicular release at simple glutamatergic synapses
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/74ed8df94cbc4fd0a111f0e6a354cd32
work_keys_str_mv	AT takafumimiki twocomponentlatencydistributionsindicatetwostepvesicularreleaseatsimpleglutamatergicsynapses AT yukihironakamura twocomponentlatencydistributionsindicatetwostepvesicularreleaseatsimpleglutamatergicsynapses AT gerardomalagon twocomponentlatencydistributionsindicatetwostepvesicularreleaseatsimpleglutamatergicsynapses AT erwinneher twocomponentlatencydistributionsindicatetwostepvesicularreleaseatsimpleglutamatergicsynapses AT alainmarty twocomponentlatencydistributionsindicatetwostepvesicularreleaseatsimpleglutamatergicsynapses
_version_	1718383284948303872

Two-component latency distributions indicate two-step vesicular release at simple glutamatergic synapses

Ejemplares similares