Heteromeric Anopheline odorant receptors exhibit distinct channel properties.

<h4>Background</h4>Insect odorant receptors (ORs) function as odorant-gated ion channels consisting of a conventional, odorant-binding OR and the Orco coreceptor. While Orco can function as a homomeric ion channel, the role(s) of the conventional OR in heteromeric OR complexes has largel...

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Autores principales:	Gregory M Pask, Patrick L Jones, Michael Rützler, David C Rinker, Laurence J Zwiebel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/74ef5fd23ceb4e3b9cf240e2ea6cae9b
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spelling	oai:doaj.org-article:74ef5fd23ceb4e3b9cf240e2ea6cae9b2021-11-18T07:32:35ZHeteromeric Anopheline odorant receptors exhibit distinct channel properties.1932-620310.1371/journal.pone.0028774https://doaj.org/article/74ef5fd23ceb4e3b9cf240e2ea6cae9b2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22174894/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Insect odorant receptors (ORs) function as odorant-gated ion channels consisting of a conventional, odorant-binding OR and the Orco coreceptor. While Orco can function as a homomeric ion channel, the role(s) of the conventional OR in heteromeric OR complexes has largely focused only on odorant recognition.<h4>Results</h4>To investigate other roles of odorant-binding ORs, we have employed patch clamp electrophysiology to investigate the properties of the channel pore of several OR complexes formed by a range of different odorant-specific Anopheles gambiae ORs (AgOrs) each paired with AgOrco. These studies reveal significant differences in cation permeability and ruthenium red susceptibility among different AgOr complexes.<h4>Conclusions</h4>With observable differences in channel function, the data support a model in which the odorant-binding OR also affects the channel pore. The variable effect contributed by the conventional OR on the conductive properties of odorant-gated sensory channels adds additional complexity to insect olfactory signaling, with differences in odor coding beginning with ORs on the periphery of the olfactory system.Gregory M PaskPatrick L JonesMichael RützlerDavid C RinkerLaurence J ZwiebelPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 12, p e28774 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gregory M Pask Patrick L Jones Michael Rützler David C Rinker Laurence J Zwiebel Heteromeric Anopheline odorant receptors exhibit distinct channel properties.
description	<h4>Background</h4>Insect odorant receptors (ORs) function as odorant-gated ion channels consisting of a conventional, odorant-binding OR and the Orco coreceptor. While Orco can function as a homomeric ion channel, the role(s) of the conventional OR in heteromeric OR complexes has largely focused only on odorant recognition.<h4>Results</h4>To investigate other roles of odorant-binding ORs, we have employed patch clamp electrophysiology to investigate the properties of the channel pore of several OR complexes formed by a range of different odorant-specific Anopheles gambiae ORs (AgOrs) each paired with AgOrco. These studies reveal significant differences in cation permeability and ruthenium red susceptibility among different AgOr complexes.<h4>Conclusions</h4>With observable differences in channel function, the data support a model in which the odorant-binding OR also affects the channel pore. The variable effect contributed by the conventional OR on the conductive properties of odorant-gated sensory channels adds additional complexity to insect olfactory signaling, with differences in odor coding beginning with ORs on the periphery of the olfactory system.
format	article
author	Gregory M Pask Patrick L Jones Michael Rützler David C Rinker Laurence J Zwiebel
author_facet	Gregory M Pask Patrick L Jones Michael Rützler David C Rinker Laurence J Zwiebel
author_sort	Gregory M Pask
title	Heteromeric Anopheline odorant receptors exhibit distinct channel properties.
title_short	Heteromeric Anopheline odorant receptors exhibit distinct channel properties.
title_full	Heteromeric Anopheline odorant receptors exhibit distinct channel properties.
title_fullStr	Heteromeric Anopheline odorant receptors exhibit distinct channel properties.
title_full_unstemmed	Heteromeric Anopheline odorant receptors exhibit distinct channel properties.
title_sort	heteromeric anopheline odorant receptors exhibit distinct channel properties.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/74ef5fd23ceb4e3b9cf240e2ea6cae9b
work_keys_str_mv	AT gregorympask heteromericanophelineodorantreceptorsexhibitdistinctchannelproperties AT patrickljones heteromericanophelineodorantreceptorsexhibitdistinctchannelproperties AT michaelrutzler heteromericanophelineodorantreceptorsexhibitdistinctchannelproperties AT davidcrinker heteromericanophelineodorantreceptorsexhibitdistinctchannelproperties AT laurencejzwiebel heteromericanophelineodorantreceptorsexhibitdistinctchannelproperties
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Heteromeric Anopheline odorant receptors exhibit distinct channel properties.

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