Prevalence and factors predictive of intraocular fungal infection in patients with fungemia at an academic urban tertiary care center

Elena Geraymovych,1 Joseph H Conduff,2 Puneet S Braich,3 Christopher T Leffler,3 Vikram S Brar3 1Department of Ophthalmology, University of Texas Health Science Center at San Antonio, San Antonio, TX, 2Virginia Commonwealth University School of Medicine, 3Department of Ophthalmology, Virginia Commo...

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Autores principales:	Geraymovych E, Conduff JH, Braich PS, Leffler CT, Brar VS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/74f0fc7cf54340bf86db04fc3a287d25
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spelling	oai:doaj.org-article:74f0fc7cf54340bf86db04fc3a287d252021-12-02T04:25:25ZPrevalence and factors predictive of intraocular fungal infection in patients with fungemia at an academic urban tertiary care center1177-5483https://doaj.org/article/74f0fc7cf54340bf86db04fc3a287d252015-09-01T00:00:00Zhttps://www.dovepress.com/prevalence-and-factors-predictive-of-intraocular-fungal-infection-in-p-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Elena Geraymovych,1 Joseph H Conduff,2 Puneet S Braich,3 Christopher T Leffler,3 Vikram S Brar3 1Department of Ophthalmology, University of Texas Health Science Center at San Antonio, San Antonio, TX, 2Virginia Commonwealth University School of Medicine, 3Department of Ophthalmology, Virginia Commonwealth University, Richmond, VA, USA Objective: To report the prevalence and to identify factors predictive of intraocular infection in patients with fungemia receiving prophylactic antifungal therapy. Methods: A retrospective review of patients who received prophylactic antifungal therapy and a dilated fundus examination at an academic urban tertiary care center from 2000 to 2007. Basic demographic information, fungal species grown, antifungal agent(s) used, number of positive blood culture specimens, visual acuity, visual symptoms, and known risks of disseminated candidiasis were noted. Logistic regression analysis was used to determine the factors significantly associated with intraocular fungal infection. Results: A total of 132 patients with positive fungemia culture were requested to have ophthalmology consults. The prevalence of ocular infection was 6.9% (N=9). All nine patients were infected with Candida species. Undergoing gastrointestinal (GI) surgery within the prior 6 months was significantly related to developing intraocular infection, with an odds ratio of 18.5 (95% confidence interval, 15.1–24.3; P=0.002). Having ≥3 positive fungal blood cultures was also a significant risk factor, with an odds ratio of 2.6 (95% confidence interval, 1.8–3.7; P=0.03). Among 40 patients having GI surgery, eight (20.0%) had intraocular fungal disease, compared with one of 92 patients (1.1%) not having GI surgery. Among 125 patients with a negative baseline examination result, two of 32 patients (6.3%), who had recent GI surgery, subsequently developed fungal ocular disease, compared with 0 of 93 patients (0%), who did not have recent GI surgery. Conclusion: Recent GI surgery and higher numbers of positive fungal blood culture specimens may be predictive of candida ocular infections. Normal baseline fundoscopy examination results in patients with such risks may require repeat evaluations to detect delayed manifestations. Keywords: fungal chorioretinitis, fungal endophthalmitis, risks factors for intraocular fungal infection, risks of gasterointestinal surgeryGeraymovych EConduff JHBraich PSLeffler CTBrar VSDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 1853-1858 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Geraymovych E Conduff JH Braich PS Leffler CT Brar VS Prevalence and factors predictive of intraocular fungal infection in patients with fungemia at an academic urban tertiary care center
description	Elena Geraymovych,1 Joseph H Conduff,2 Puneet S Braich,3 Christopher T Leffler,3 Vikram S Brar3 1Department of Ophthalmology, University of Texas Health Science Center at San Antonio, San Antonio, TX, 2Virginia Commonwealth University School of Medicine, 3Department of Ophthalmology, Virginia Commonwealth University, Richmond, VA, USA Objective: To report the prevalence and to identify factors predictive of intraocular infection in patients with fungemia receiving prophylactic antifungal therapy. Methods: A retrospective review of patients who received prophylactic antifungal therapy and a dilated fundus examination at an academic urban tertiary care center from 2000 to 2007. Basic demographic information, fungal species grown, antifungal agent(s) used, number of positive blood culture specimens, visual acuity, visual symptoms, and known risks of disseminated candidiasis were noted. Logistic regression analysis was used to determine the factors significantly associated with intraocular fungal infection. Results: A total of 132 patients with positive fungemia culture were requested to have ophthalmology consults. The prevalence of ocular infection was 6.9% (N=9). All nine patients were infected with Candida species. Undergoing gastrointestinal (GI) surgery within the prior 6 months was significantly related to developing intraocular infection, with an odds ratio of 18.5 (95% confidence interval, 15.1–24.3; P=0.002). Having ≥3 positive fungal blood cultures was also a significant risk factor, with an odds ratio of 2.6 (95% confidence interval, 1.8–3.7; P=0.03). Among 40 patients having GI surgery, eight (20.0%) had intraocular fungal disease, compared with one of 92 patients (1.1%) not having GI surgery. Among 125 patients with a negative baseline examination result, two of 32 patients (6.3%), who had recent GI surgery, subsequently developed fungal ocular disease, compared with 0 of 93 patients (0%), who did not have recent GI surgery. Conclusion: Recent GI surgery and higher numbers of positive fungal blood culture specimens may be predictive of candida ocular infections. Normal baseline fundoscopy examination results in patients with such risks may require repeat evaluations to detect delayed manifestations. Keywords: fungal chorioretinitis, fungal endophthalmitis, risks factors for intraocular fungal infection, risks of gasterointestinal surgery
format	article
author	Geraymovych E Conduff JH Braich PS Leffler CT Brar VS
author_facet	Geraymovych E Conduff JH Braich PS Leffler CT Brar VS
author_sort	Geraymovych E
title	Prevalence and factors predictive of intraocular fungal infection in patients with fungemia at an academic urban tertiary care center
title_short	Prevalence and factors predictive of intraocular fungal infection in patients with fungemia at an academic urban tertiary care center
title_full	Prevalence and factors predictive of intraocular fungal infection in patients with fungemia at an academic urban tertiary care center
title_fullStr	Prevalence and factors predictive of intraocular fungal infection in patients with fungemia at an academic urban tertiary care center
title_full_unstemmed	Prevalence and factors predictive of intraocular fungal infection in patients with fungemia at an academic urban tertiary care center
title_sort	prevalence and factors predictive of intraocular fungal infection in patients with fungemia at an academic urban tertiary care center
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/74f0fc7cf54340bf86db04fc3a287d25
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Prevalence and factors predictive of intraocular fungal infection in patients with fungemia at an academic urban tertiary care center

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