NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice

Rift Valley fever virus (RVFV) can cause severe diseases in humans, including encephalitis. Here the authors show that NSs, the major virulence factor of RVFV, is an amyloidogenic protein forming fibrils in infected mouse brains and causing increased mortality in mice.

Guardado en:

Detalles Bibliográficos
Autores principales:	Psylvia Léger, Eliana Nachman, Karsten Richter, Carole Tamietti, Jana Koch, Robin Burk, Susann Kummer, Qilin Xin, Megan Stanifer, Michèle Bouloy, Steeve Boulant, Hans-Georg Kräusslich, Xavier Montagutelli, Marie Flamand, Carmen Nussbaum-Krammer, Pierre-Yves Lozach
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/74f1f51789f34696aeebabd489877a8c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:74f1f51789f34696aeebabd489877a8c
record_format	dspace
spelling	oai:doaj.org-article:74f1f51789f34696aeebabd489877a8c2021-12-02T16:32:14ZNSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice10.1038/s41467-020-17101-y2041-1723https://doaj.org/article/74f1f51789f34696aeebabd489877a8c2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17101-yhttps://doaj.org/toc/2041-1723Rift Valley fever virus (RVFV) can cause severe diseases in humans, including encephalitis. Here the authors show that NSs, the major virulence factor of RVFV, is an amyloidogenic protein forming fibrils in infected mouse brains and causing increased mortality in mice.Psylvia LégerEliana NachmanKarsten RichterCarole TamiettiJana KochRobin BurkSusann KummerQilin XinMegan StaniferMichèle BouloySteeve BoulantHans-Georg KräusslichXavier MontagutelliMarie FlamandCarmen Nussbaum-KrammerPierre-Yves LozachNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Psylvia Léger Eliana Nachman Karsten Richter Carole Tamietti Jana Koch Robin Burk Susann Kummer Qilin Xin Megan Stanifer Michèle Bouloy Steeve Boulant Hans-Georg Kräusslich Xavier Montagutelli Marie Flamand Carmen Nussbaum-Krammer Pierre-Yves Lozach NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice
description	Rift Valley fever virus (RVFV) can cause severe diseases in humans, including encephalitis. Here the authors show that NSs, the major virulence factor of RVFV, is an amyloidogenic protein forming fibrils in infected mouse brains and causing increased mortality in mice.
format	article
author	Psylvia Léger Eliana Nachman Karsten Richter Carole Tamietti Jana Koch Robin Burk Susann Kummer Qilin Xin Megan Stanifer Michèle Bouloy Steeve Boulant Hans-Georg Kräusslich Xavier Montagutelli Marie Flamand Carmen Nussbaum-Krammer Pierre-Yves Lozach
author_facet	Psylvia Léger Eliana Nachman Karsten Richter Carole Tamietti Jana Koch Robin Burk Susann Kummer Qilin Xin Megan Stanifer Michèle Bouloy Steeve Boulant Hans-Georg Kräusslich Xavier Montagutelli Marie Flamand Carmen Nussbaum-Krammer Pierre-Yves Lozach
author_sort	Psylvia Léger
title	NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice
title_short	NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice
title_full	NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice
title_fullStr	NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice
title_full_unstemmed	NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice
title_sort	nss amyloid formation is associated with the virulence of rift valley fever virus in mice
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/74f1f51789f34696aeebabd489877a8c
work_keys_str_mv	AT psylvialeger nssamyloidformationisassociatedwiththevirulenceofriftvalleyfevervirusinmice AT eliananachman nssamyloidformationisassociatedwiththevirulenceofriftvalleyfevervirusinmice AT karstenrichter nssamyloidformationisassociatedwiththevirulenceofriftvalleyfevervirusinmice AT caroletamietti nssamyloidformationisassociatedwiththevirulenceofriftvalleyfevervirusinmice AT janakoch nssamyloidformationisassociatedwiththevirulenceofriftvalleyfevervirusinmice AT robinburk nssamyloidformationisassociatedwiththevirulenceofriftvalleyfevervirusinmice AT susannkummer nssamyloidformationisassociatedwiththevirulenceofriftvalleyfevervirusinmice AT qilinxin nssamyloidformationisassociatedwiththevirulenceofriftvalleyfevervirusinmice AT meganstanifer nssamyloidformationisassociatedwiththevirulenceofriftvalleyfevervirusinmice AT michelebouloy nssamyloidformationisassociatedwiththevirulenceofriftvalleyfevervirusinmice AT steeveboulant nssamyloidformationisassociatedwiththevirulenceofriftvalleyfevervirusinmice AT hansgeorgkrausslich nssamyloidformationisassociatedwiththevirulenceofriftvalleyfevervirusinmice AT xaviermontagutelli nssamyloidformationisassociatedwiththevirulenceofriftvalleyfevervirusinmice AT marieflamand nssamyloidformationisassociatedwiththevirulenceofriftvalleyfevervirusinmice AT carmennussbaumkrammer nssamyloidformationisassociatedwiththevirulenceofriftvalleyfevervirusinmice AT pierreyveslozach nssamyloidformationisassociatedwiththevirulenceofriftvalleyfevervirusinmice
_version_	1718383816214577152

NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice

Ejemplares similares