Influence of biological markers on overall survival in surgically treated patients with non-small cell lung cancer

Background/Aim. Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors and a leading cause of cancer-related deaths. The aim of this study was to assess the impact of biological markers on the overall survival rate in surgically treated NSCLC patients who received adjuvant che...

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Autores principales:	Lončarević Olivera, Lončarević Slobodan, Vekić Berislav, Đukanović Leonida, Vuković Jelena, Rančić Nemanja
Formato:	article
Lenguaje:	EN SR
Publicado:	Military Health Department, Ministry of Defance, Serbia 2021
Materias:	biomarkers carcinoma, non-small-cell lung immunohistochemistry survival neoplasm staging surgical procedures, operative Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/74f2cf493cb74e868f51b33e7441b553
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spelling	oai:doaj.org-article:74f2cf493cb74e868f51b33e7441b5532021-12-01T13:00:25ZInfluence of biological markers on overall survival in surgically treated patients with non-small cell lung cancer0042-84502406-072010.2298/VSP191030035Lhttps://doaj.org/article/74f2cf493cb74e868f51b33e7441b5532021-01-01T00:00:00Zhttp://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84502000035L.pdfhttps://doaj.org/toc/0042-8450https://doaj.org/toc/2406-0720Background/Aim. Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors and a leading cause of cancer-related deaths. The aim of this study was to assess the impact of biological markers on the overall survival rate in surgically treated NSCLC patients who received adjuvant chemotherapy and/or radiation therapy. Methods. This retrospective case series study included patients with NSCLC treated in the period between 2008 and 2017 at the Pulmonology Clinic and the Clinic for Chest Surgery, Military Medical Academy, Belgrade, Serbia. The survival analysis performed was based on immunohistological findings, histology type, and tumor, node, metastasis (TNM) stages. Results. The mortality rate was higher in the adenocarcinoma patient group compared to the squamous cell carcinoma group, albeit without statistical significance (58.3% vs. 31.2%, respectively; p = 0.175). Overall survival was shorter in the adenocarcinoma patient group compared to the squamous cell carcinoma group by approximately 750 days. Likewise, overall survival was shorter in the adenocarcinoma patient group compared to the squamous cell carcinoma group for CD31 positive (p = 0.029), p-63 positive (p = 0.049), MMP-9 positive (p = 0.032), and matrix metalloproteinase (MMP)-2 positive patients (p = 0.016). Conclusion. Adenocarcinoma is a more aggressive cancer type compared to squamous cell carcinoma with shorter overall survival. Our research showed a poorer overall survival in the adeno-carcinoma group of patients compared to the squamous cell carcinoma group in CD31, p-63, MMP-9, and MMP-2 positive patients.Lončarević OliveraLončarević SlobodanVekić BerislavĐukanović LeonidaVuković JelenaRančić NemanjaMilitary Health Department, Ministry of Defance, Serbiaarticlebiomarkerscarcinoma, non-small-cell lungimmunohistochemistrysurvivalneoplasm stagingsurgical procedures, operativeMedicine (General)R5-920ENSRVojnosanitetski Pregled, Vol 78, Iss 11, Pp 1155-1165 (2021)
institution	DOAJ
collection	DOAJ
language	EN SR
topic	biomarkers carcinoma, non-small-cell lung immunohistochemistry survival neoplasm staging surgical procedures, operative Medicine (General) R5-920
spellingShingle	biomarkers carcinoma, non-small-cell lung immunohistochemistry survival neoplasm staging surgical procedures, operative Medicine (General) R5-920 Lončarević Olivera Lončarević Slobodan Vekić Berislav Đukanović Leonida Vuković Jelena Rančić Nemanja Influence of biological markers on overall survival in surgically treated patients with non-small cell lung cancer
description	Background/Aim. Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors and a leading cause of cancer-related deaths. The aim of this study was to assess the impact of biological markers on the overall survival rate in surgically treated NSCLC patients who received adjuvant chemotherapy and/or radiation therapy. Methods. This retrospective case series study included patients with NSCLC treated in the period between 2008 and 2017 at the Pulmonology Clinic and the Clinic for Chest Surgery, Military Medical Academy, Belgrade, Serbia. The survival analysis performed was based on immunohistological findings, histology type, and tumor, node, metastasis (TNM) stages. Results. The mortality rate was higher in the adenocarcinoma patient group compared to the squamous cell carcinoma group, albeit without statistical significance (58.3% vs. 31.2%, respectively; p = 0.175). Overall survival was shorter in the adenocarcinoma patient group compared to the squamous cell carcinoma group by approximately 750 days. Likewise, overall survival was shorter in the adenocarcinoma patient group compared to the squamous cell carcinoma group for CD31 positive (p = 0.029), p-63 positive (p = 0.049), MMP-9 positive (p = 0.032), and matrix metalloproteinase (MMP)-2 positive patients (p = 0.016). Conclusion. Adenocarcinoma is a more aggressive cancer type compared to squamous cell carcinoma with shorter overall survival. Our research showed a poorer overall survival in the adeno-carcinoma group of patients compared to the squamous cell carcinoma group in CD31, p-63, MMP-9, and MMP-2 positive patients.
format	article
author	Lončarević Olivera Lončarević Slobodan Vekić Berislav Đukanović Leonida Vuković Jelena Rančić Nemanja
author_facet	Lončarević Olivera Lončarević Slobodan Vekić Berislav Đukanović Leonida Vuković Jelena Rančić Nemanja
author_sort	Lončarević Olivera
title	Influence of biological markers on overall survival in surgically treated patients with non-small cell lung cancer
title_short	Influence of biological markers on overall survival in surgically treated patients with non-small cell lung cancer
title_full	Influence of biological markers on overall survival in surgically treated patients with non-small cell lung cancer
title_fullStr	Influence of biological markers on overall survival in surgically treated patients with non-small cell lung cancer
title_full_unstemmed	Influence of biological markers on overall survival in surgically treated patients with non-small cell lung cancer
title_sort	influence of biological markers on overall survival in surgically treated patients with non-small cell lung cancer
publisher	Military Health Department, Ministry of Defance, Serbia
publishDate	2021
url	https://doaj.org/article/74f2cf493cb74e868f51b33e7441b553
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Influence of biological markers on overall survival in surgically treated patients with non-small cell lung cancer

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