Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion

Ephrin receptors mediate contact inhibition, but their intracellular trafficking during this process is unknown. Here the authors show that EphA2 receptor trafficking is regulated by the Rab GTPase effector Rab-coupling protein, which associates with Rab14-endosomes upon LMTK3-mediated phosphorylati...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Christine Gundry, Sergi Marco, Elena Rainero, Bryan Miller, Emmanuel Dornier, Louise Mitchell, Patrick T. Caswell, Andrew D. Campbell, Anna Hogeweg, Owen J. Sansom, Jennifer P. Morton, Jim C. Norman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/74f2ebe037a54017b8f114ad988e154b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:74f2ebe037a54017b8f114ad988e154b
record_format	dspace
spelling	oai:doaj.org-article:74f2ebe037a54017b8f114ad988e154b2021-12-02T15:38:51ZPhosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion10.1038/ncomms146462041-1723https://doaj.org/article/74f2ebe037a54017b8f114ad988e154b2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14646https://doaj.org/toc/2041-1723Ephrin receptors mediate contact inhibition, but their intracellular trafficking during this process is unknown. Here the authors show that EphA2 receptor trafficking is regulated by the Rab GTPase effector Rab-coupling protein, which associates with Rab14-endosomes upon LMTK3-mediated phosphorylation.Christine GundrySergi MarcoElena RaineroBryan MillerEmmanuel DornierLouise MitchellPatrick T. CaswellAndrew D. CampbellAnna HogewegOwen J. SansomJennifer P. MortonJim C. NormanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christine Gundry Sergi Marco Elena Rainero Bryan Miller Emmanuel Dornier Louise Mitchell Patrick T. Caswell Andrew D. Campbell Anna Hogeweg Owen J. Sansom Jennifer P. Morton Jim C. Norman Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion
description	Ephrin receptors mediate contact inhibition, but their intracellular trafficking during this process is unknown. Here the authors show that EphA2 receptor trafficking is regulated by the Rab GTPase effector Rab-coupling protein, which associates with Rab14-endosomes upon LMTK3-mediated phosphorylation.
format	article
author	Christine Gundry Sergi Marco Elena Rainero Bryan Miller Emmanuel Dornier Louise Mitchell Patrick T. Caswell Andrew D. Campbell Anna Hogeweg Owen J. Sansom Jennifer P. Morton Jim C. Norman
author_facet	Christine Gundry Sergi Marco Elena Rainero Bryan Miller Emmanuel Dornier Louise Mitchell Patrick T. Caswell Andrew D. Campbell Anna Hogeweg Owen J. Sansom Jennifer P. Morton Jim C. Norman
author_sort	Christine Gundry
title	Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion
title_short	Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion
title_full	Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion
title_fullStr	Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion
title_full_unstemmed	Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion
title_sort	phosphorylation of rab-coupling protein by lmtk3 controls rab14-dependent epha2 trafficking to promote cell:cell repulsion
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/74f2ebe037a54017b8f114ad988e154b
work_keys_str_mv	AT christinegundry phosphorylationofrabcouplingproteinbylmtk3controlsrab14dependentepha2traffickingtopromotecellcellrepulsion AT sergimarco phosphorylationofrabcouplingproteinbylmtk3controlsrab14dependentepha2traffickingtopromotecellcellrepulsion AT elenarainero phosphorylationofrabcouplingproteinbylmtk3controlsrab14dependentepha2traffickingtopromotecellcellrepulsion AT bryanmiller phosphorylationofrabcouplingproteinbylmtk3controlsrab14dependentepha2traffickingtopromotecellcellrepulsion AT emmanueldornier phosphorylationofrabcouplingproteinbylmtk3controlsrab14dependentepha2traffickingtopromotecellcellrepulsion AT louisemitchell phosphorylationofrabcouplingproteinbylmtk3controlsrab14dependentepha2traffickingtopromotecellcellrepulsion AT patricktcaswell phosphorylationofrabcouplingproteinbylmtk3controlsrab14dependentepha2traffickingtopromotecellcellrepulsion AT andrewdcampbell phosphorylationofrabcouplingproteinbylmtk3controlsrab14dependentepha2traffickingtopromotecellcellrepulsion AT annahogeweg phosphorylationofrabcouplingproteinbylmtk3controlsrab14dependentepha2traffickingtopromotecellcellrepulsion AT owenjsansom phosphorylationofrabcouplingproteinbylmtk3controlsrab14dependentepha2traffickingtopromotecellcellrepulsion AT jenniferpmorton phosphorylationofrabcouplingproteinbylmtk3controlsrab14dependentepha2traffickingtopromotecellcellrepulsion AT jimcnorman phosphorylationofrabcouplingproteinbylmtk3controlsrab14dependentepha2traffickingtopromotecellcellrepulsion
_version_	1718386056015904768

Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion

Ejemplares similares