Astrocyte deletion of α2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway
Mutations of α2-Na/K ATPase can cause familial hemiplegic migraine via unclear mechanisms. Here, the authors show that deletion of α2-Na/K ATPase in astrocytes results in gene expression and metabolic changes leading to cortical spreading depression and episodic transient motor paralysis in mice.
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Nature Portfolio
2020
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oai:doaj.org-article:74f61a96ce2a40c79d4e03f28f0e919d2021-12-02T17:31:25ZAstrocyte deletion of α2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway10.1038/s41467-020-19915-22041-1723https://doaj.org/article/74f61a96ce2a40c79d4e03f28f0e919d2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19915-2https://doaj.org/toc/2041-1723Mutations of α2-Na/K ATPase can cause familial hemiplegic migraine via unclear mechanisms. Here, the authors show that deletion of α2-Na/K ATPase in astrocytes results in gene expression and metabolic changes leading to cortical spreading depression and episodic transient motor paralysis in mice.Sarah E. SmithXiaoying ChenLindsey M. BrierJonathan R. BumsteadNicholas R. RensingAlison E. RingelHaewon ShinAnna OldenborgJan R. CrowleyAnnie R. BiceKrikor DikranianJoseph E. IppolitoMarcia C. HaigisThomas PapouinGuoyan ZhaoMichael WongJoseph P. CulverAzad BonniNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Sarah E. Smith Xiaoying Chen Lindsey M. Brier Jonathan R. Bumstead Nicholas R. Rensing Alison E. Ringel Haewon Shin Anna Oldenborg Jan R. Crowley Annie R. Bice Krikor Dikranian Joseph E. Ippolito Marcia C. Haigis Thomas Papouin Guoyan Zhao Michael Wong Joseph P. Culver Azad Bonni Astrocyte deletion of α2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway |
| description |
Mutations of α2-Na/K ATPase can cause familial hemiplegic migraine via unclear mechanisms. Here, the authors show that deletion of α2-Na/K ATPase in astrocytes results in gene expression and metabolic changes leading to cortical spreading depression and episodic transient motor paralysis in mice. |
| format |
article |
| author |
Sarah E. Smith Xiaoying Chen Lindsey M. Brier Jonathan R. Bumstead Nicholas R. Rensing Alison E. Ringel Haewon Shin Anna Oldenborg Jan R. Crowley Annie R. Bice Krikor Dikranian Joseph E. Ippolito Marcia C. Haigis Thomas Papouin Guoyan Zhao Michael Wong Joseph P. Culver Azad Bonni |
| author_facet |
Sarah E. Smith Xiaoying Chen Lindsey M. Brier Jonathan R. Bumstead Nicholas R. Rensing Alison E. Ringel Haewon Shin Anna Oldenborg Jan R. Crowley Annie R. Bice Krikor Dikranian Joseph E. Ippolito Marcia C. Haigis Thomas Papouin Guoyan Zhao Michael Wong Joseph P. Culver Azad Bonni |
| author_sort |
Sarah E. Smith |
| title |
Astrocyte deletion of α2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway |
| title_short |
Astrocyte deletion of α2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway |
| title_full |
Astrocyte deletion of α2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway |
| title_fullStr |
Astrocyte deletion of α2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway |
| title_full_unstemmed |
Astrocyte deletion of α2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway |
| title_sort |
astrocyte deletion of α2-na/k atpase triggers episodic motor paralysis in mice via a metabolic pathway |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/74f61a96ce2a40c79d4e03f28f0e919d |
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