Constitutive PGC-1α overexpression in skeletal muscle does not protect from age-dependent decline in neurogenesis

Abstract Aerobic exercise prevents age-dependent decline in cognition and hippocampal neurogenesis. The transcription factor peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC-1α) mediates many of the exercise-induced benefits in skeletal muscle, including the release of fact...

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Autores principales: Lars Karlsson, María Nazareth González-Alvarado, Reza Motalleb, Klas Blomgren, Mats Börjesson, Hans Georg Kuhn
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/74f670ac4f37438ab1c911718eab4057
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