Patient-derived xenografts and organoids model therapy response in prostate cancer

To date, patients still succumb to cancer, due to tumors not responding to therapy or ultimately acquiring resistance. Here the authors show that by exploiting patient derived organoids and a treatment-naïve patient derived xenograft, patient therapy can be personalized.

Guardado en:

Detalles Bibliográficos
Autores principales:	Sofia Karkampouna, Federico La Manna, Andrej Benjak, Mirjam Kiener, Marta De Menna, Eugenio Zoni, Joël Grosjean, Irena Klima, Andrea Garofoli, Marco Bolis, Arianna Vallerga, Jean-Philippe Theurillat, Maria R. De Filippo, Vera Genitsch, David Keller, Tijmen H. Booij, Christian U. Stirnimann, Kenneth Eng, Andrea Sboner, Charlotte K. Y. Ng, Salvatore Piscuoglio, Peter C. Gray, Martin Spahn, Mark A. Rubin, George N. Thalmann, Marianna Kruithof-de Julio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/74f8126482f64e7aa57d9156cdf767c0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:74f8126482f64e7aa57d9156cdf767c0
record_format	dspace
spelling	oai:doaj.org-article:74f8126482f64e7aa57d9156cdf767c02021-12-02T14:03:39ZPatient-derived xenografts and organoids model therapy response in prostate cancer10.1038/s41467-021-21300-62041-1723https://doaj.org/article/74f8126482f64e7aa57d9156cdf767c02021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21300-6https://doaj.org/toc/2041-1723To date, patients still succumb to cancer, due to tumors not responding to therapy or ultimately acquiring resistance. Here the authors show that by exploiting patient derived organoids and a treatment-naïve patient derived xenograft, patient therapy can be personalized.Sofia KarkampounaFederico La MannaAndrej BenjakMirjam KienerMarta De MennaEugenio ZoniJoël GrosjeanIrena KlimaAndrea GarofoliMarco BolisArianna VallergaJean-Philippe TheurillatMaria R. De FilippoVera GenitschDavid KellerTijmen H. BooijChristian U. StirnimannKenneth EngAndrea SbonerCharlotte K. Y. NgSalvatore PiscuoglioPeter C. GrayMartin SpahnMark A. RubinGeorge N. ThalmannMarianna Kruithof-de JulioNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sofia Karkampouna Federico La Manna Andrej Benjak Mirjam Kiener Marta De Menna Eugenio Zoni Joël Grosjean Irena Klima Andrea Garofoli Marco Bolis Arianna Vallerga Jean-Philippe Theurillat Maria R. De Filippo Vera Genitsch David Keller Tijmen H. Booij Christian U. Stirnimann Kenneth Eng Andrea Sboner Charlotte K. Y. Ng Salvatore Piscuoglio Peter C. Gray Martin Spahn Mark A. Rubin George N. Thalmann Marianna Kruithof-de Julio Patient-derived xenografts and organoids model therapy response in prostate cancer
description	To date, patients still succumb to cancer, due to tumors not responding to therapy or ultimately acquiring resistance. Here the authors show that by exploiting patient derived organoids and a treatment-naïve patient derived xenograft, patient therapy can be personalized.
format	article
author	Sofia Karkampouna Federico La Manna Andrej Benjak Mirjam Kiener Marta De Menna Eugenio Zoni Joël Grosjean Irena Klima Andrea Garofoli Marco Bolis Arianna Vallerga Jean-Philippe Theurillat Maria R. De Filippo Vera Genitsch David Keller Tijmen H. Booij Christian U. Stirnimann Kenneth Eng Andrea Sboner Charlotte K. Y. Ng Salvatore Piscuoglio Peter C. Gray Martin Spahn Mark A. Rubin George N. Thalmann Marianna Kruithof-de Julio
author_facet	Sofia Karkampouna Federico La Manna Andrej Benjak Mirjam Kiener Marta De Menna Eugenio Zoni Joël Grosjean Irena Klima Andrea Garofoli Marco Bolis Arianna Vallerga Jean-Philippe Theurillat Maria R. De Filippo Vera Genitsch David Keller Tijmen H. Booij Christian U. Stirnimann Kenneth Eng Andrea Sboner Charlotte K. Y. Ng Salvatore Piscuoglio Peter C. Gray Martin Spahn Mark A. Rubin George N. Thalmann Marianna Kruithof-de Julio
author_sort	Sofia Karkampouna
title	Patient-derived xenografts and organoids model therapy response in prostate cancer
title_short	Patient-derived xenografts and organoids model therapy response in prostate cancer
title_full	Patient-derived xenografts and organoids model therapy response in prostate cancer
title_fullStr	Patient-derived xenografts and organoids model therapy response in prostate cancer
title_full_unstemmed	Patient-derived xenografts and organoids model therapy response in prostate cancer
title_sort	patient-derived xenografts and organoids model therapy response in prostate cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/74f8126482f64e7aa57d9156cdf767c0
work_keys_str_mv	AT sofiakarkampouna patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer AT federicolamanna patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer AT andrejbenjak patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer AT mirjamkiener patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer AT martademenna patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer AT eugeniozoni patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer AT joelgrosjean patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer AT irenaklima patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer AT andreagarofoli patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer AT marcobolis patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer AT ariannavallerga patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer AT jeanphilippetheurillat patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer AT mariardefilippo patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer AT veragenitsch patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer AT davidkeller patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer AT tijmenhbooij patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer AT christianustirnimann patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer AT kennetheng patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer AT andreasboner patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer AT charlottekyng patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer AT salvatorepiscuoglio patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer AT petercgray patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer AT martinspahn patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer AT markarubin patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer AT georgenthalmann patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer AT mariannakruithofdejulio patientderivedxenograftsandorganoidsmodeltherapyresponseinprostatecancer
_version_	1718392088757796864

Patient-derived xenografts and organoids model therapy response in prostate cancer

Ejemplares similares