Programmable DNA looping using engineered bivalent dCas9 complexes

DNA loops are a ubiquitious feature of gene regulation across the kingdoms of life. Here the authors design a Cas9-based dimerization system for inducing DNA loops in E. coli, allowing activation and rewiring of gene expression.

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Detalles Bibliográficos
Autores principales:	Nan Hao, Keith E. Shearwin, Ian B. Dodd
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/74f9626a97ce451fafaa5aa6b162cad8
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spelling	oai:doaj.org-article:74f9626a97ce451fafaa5aa6b162cad82021-12-02T15:38:53ZProgrammable DNA looping using engineered bivalent dCas9 complexes10.1038/s41467-017-01873-x2041-1723https://doaj.org/article/74f9626a97ce451fafaa5aa6b162cad82017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01873-xhttps://doaj.org/toc/2041-1723DNA loops are a ubiquitious feature of gene regulation across the kingdoms of life. Here the authors design a Cas9-based dimerization system for inducing DNA loops in E. coli, allowing activation and rewiring of gene expression.Nan HaoKeith E. ShearwinIan B. DoddNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nan Hao Keith E. Shearwin Ian B. Dodd Programmable DNA looping using engineered bivalent dCas9 complexes
description	DNA loops are a ubiquitious feature of gene regulation across the kingdoms of life. Here the authors design a Cas9-based dimerization system for inducing DNA loops in E. coli, allowing activation and rewiring of gene expression.
format	article
author	Nan Hao Keith E. Shearwin Ian B. Dodd
author_facet	Nan Hao Keith E. Shearwin Ian B. Dodd
author_sort	Nan Hao
title	Programmable DNA looping using engineered bivalent dCas9 complexes
title_short	Programmable DNA looping using engineered bivalent dCas9 complexes
title_full	Programmable DNA looping using engineered bivalent dCas9 complexes
title_fullStr	Programmable DNA looping using engineered bivalent dCas9 complexes
title_full_unstemmed	Programmable DNA looping using engineered bivalent dCas9 complexes
title_sort	programmable dna looping using engineered bivalent dcas9 complexes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/74f9626a97ce451fafaa5aa6b162cad8
work_keys_str_mv	AT nanhao programmablednaloopingusingengineeredbivalentdcas9complexes AT keitheshearwin programmablednaloopingusingengineeredbivalentdcas9complexes AT ianbdodd programmablednaloopingusingengineeredbivalentdcas9complexes
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Programmable DNA looping using engineered bivalent dCas9 complexes

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