Circulating IL-10 is compromised in patients predisposed to developing and in patients with severe knee osteoarthritis

Abstract The purpose of this investigation was to identify if serum interleukin (IL)-10 and tumor necrosis factor (TNF)-α concentrations and their ratio (IL-10/TNF-α) are altered in subjects predisposed to developing knee osteoarthritis following ligamentous injury and in those with severe knee oste...

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Autores principales:	Tyler Barker, Victoria E. Rogers, Vanessa T. Henriksen, Roy H. Trawick, Nathan G. Momberger, G. Lynn Rasmussen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/74f9bfa71507493ca38f0b7463bb1e5e
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spelling	oai:doaj.org-article:74f9bfa71507493ca38f0b7463bb1e5e2021-12-02T13:51:06ZCirculating IL-10 is compromised in patients predisposed to developing and in patients with severe knee osteoarthritis10.1038/s41598-021-81382-62045-2322https://doaj.org/article/74f9bfa71507493ca38f0b7463bb1e5e2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81382-6https://doaj.org/toc/2045-2322Abstract The purpose of this investigation was to identify if serum interleukin (IL)-10 and tumor necrosis factor (TNF)-α concentrations and their ratio (IL-10/TNF-α) are altered in subjects predisposed to developing knee osteoarthritis following ligamentous injury and in those with severe knee osteoarthritis. Serum IL-10 and TNF-α concentrations were measured in four groups of subjects (n = 218): (1) reportedly-healthy and non-injured control subjects (CON; n = 92), (2) subjects scheduled to undergo anterior cruciate ligament surgery (ACL; n = 42), (3) non-surgical subjects with knee osteoarthritis (OA; n = 60), and (4) subjects with knee osteoarthritis scheduled to undergo total knee arthroplasty (TKA; n = 24). X-ray images were used to grade the severity of knee osteoarthritis. Serum IL-10 and the serum IL-10/TNF-α ratio were significantly lower while serum TNF-α was not significantly perturbed with severe compared to moderate knee osteoarthritis (i.e., Kellgren-Lawrence grade 4 vs. 3, respectively). Serum IL-10 was significantly lower in the absence of serum TNF-α alterations in the ACL group. We conclude that serum IL-10 concentrations are compromised in subjects predisposed to developing knee osteoarthritis following ligamentous trauma and in subjects with radiographic evidence of severe knee osteoarthritis.Tyler BarkerVictoria E. RogersVanessa T. HenriksenRoy H. TrawickNathan G. MombergerG. Lynn RasmussenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tyler Barker Victoria E. Rogers Vanessa T. Henriksen Roy H. Trawick Nathan G. Momberger G. Lynn Rasmussen Circulating IL-10 is compromised in patients predisposed to developing and in patients with severe knee osteoarthritis
description	Abstract The purpose of this investigation was to identify if serum interleukin (IL)-10 and tumor necrosis factor (TNF)-α concentrations and their ratio (IL-10/TNF-α) are altered in subjects predisposed to developing knee osteoarthritis following ligamentous injury and in those with severe knee osteoarthritis. Serum IL-10 and TNF-α concentrations were measured in four groups of subjects (n = 218): (1) reportedly-healthy and non-injured control subjects (CON; n = 92), (2) subjects scheduled to undergo anterior cruciate ligament surgery (ACL; n = 42), (3) non-surgical subjects with knee osteoarthritis (OA; n = 60), and (4) subjects with knee osteoarthritis scheduled to undergo total knee arthroplasty (TKA; n = 24). X-ray images were used to grade the severity of knee osteoarthritis. Serum IL-10 and the serum IL-10/TNF-α ratio were significantly lower while serum TNF-α was not significantly perturbed with severe compared to moderate knee osteoarthritis (i.e., Kellgren-Lawrence grade 4 vs. 3, respectively). Serum IL-10 was significantly lower in the absence of serum TNF-α alterations in the ACL group. We conclude that serum IL-10 concentrations are compromised in subjects predisposed to developing knee osteoarthritis following ligamentous trauma and in subjects with radiographic evidence of severe knee osteoarthritis.
format	article
author	Tyler Barker Victoria E. Rogers Vanessa T. Henriksen Roy H. Trawick Nathan G. Momberger G. Lynn Rasmussen
author_facet	Tyler Barker Victoria E. Rogers Vanessa T. Henriksen Roy H. Trawick Nathan G. Momberger G. Lynn Rasmussen
author_sort	Tyler Barker
title	Circulating IL-10 is compromised in patients predisposed to developing and in patients with severe knee osteoarthritis
title_short	Circulating IL-10 is compromised in patients predisposed to developing and in patients with severe knee osteoarthritis
title_full	Circulating IL-10 is compromised in patients predisposed to developing and in patients with severe knee osteoarthritis
title_fullStr	Circulating IL-10 is compromised in patients predisposed to developing and in patients with severe knee osteoarthritis
title_full_unstemmed	Circulating IL-10 is compromised in patients predisposed to developing and in patients with severe knee osteoarthritis
title_sort	circulating il-10 is compromised in patients predisposed to developing and in patients with severe knee osteoarthritis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/74f9bfa71507493ca38f0b7463bb1e5e
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Circulating IL-10 is compromised in patients predisposed to developing and in patients with severe knee osteoarthritis

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