Evaluation of FGF-19 and β-klotho as biomarkers in patients with intrahepatic cholestasis of pregnancy

Introduction Fibroblast growth factor-19 (FGF-19) and its co-receptor, beta-klotho, regulate bile acid synthesis in the liver as an enterohepatic feedback mechanism. In this study, our aim was to investigate the circulating FGF-19 and β-klotho levels in intrahepatic cholestasis of pregnancy (ICP) ca...

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Autores principales:	Ahter Tanay Tayyar, Ahmet Tayyar, Sukran Kozali, Resul Karakus, Nadiye Koroglu, Ilkbal Temel Yuksel, Gonca Yetkin Yildirim, Ismail Dag, Mustafa Eroglu
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2018
Materias:	fgf-19 beta-klotho intrahepatic cholestasis of pregnancy pathogenesis cyp7a1 fibroblast growth factor-19 β-klotho Medicine R
Acceso en línea:	https://doaj.org/article/74fe58c0417943409befd84ce5273909
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spelling	oai:doaj.org-article:74fe58c0417943409befd84ce52739092021-12-02T18:39:09ZEvaluation of FGF-19 and β-klotho as biomarkers in patients with intrahepatic cholestasis of pregnancy1734-19221896-915110.5114/aoms.2017.72424https://doaj.org/article/74fe58c0417943409befd84ce52739092018-12-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Evaluation-of-FGF-19-and-klotho-as-biomarkers-in-patients-with-intrahepatic-cholestasis,81301,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction Fibroblast growth factor-19 (FGF-19) and its co-receptor, beta-klotho, regulate bile acid synthesis in the liver as an enterohepatic feedback mechanism. In this study, our aim was to investigate the circulating FGF-19 and β-klotho levels in intrahepatic cholestasis of pregnancy (ICP) cases. Material and methods A cross-sectional study including 40 women whose pregnancies were complicated with ICP were recruited for the study group. Forty randomly selected healthy pregnant women comprised the control group. The patient characteristics, including maternal age, gravidity, parity, gestational age at the time of diagnosis, body mass index (BMI), and obstetric history, were recorded. The serum FGF-19 and β-klotho concentrations were measured using an enzyme-linked immunosorbent assay. Results Maternal age, gravidity, parity, body mass index at assessment, and gestational age at blood sampling were similar between the two groups (p > 0.05). Moreover, there were no significant differences in the FGF-19 and β-klotho concentrations between the two groups (p = 0.341 and p = 0.086, respectively). A positive correlation was detected between the β-klotho and FGF-19 levels, as well as between the FGF-19 level and BMI (r = 0.368, p = 0.020 and r = 0.389, p = 0.013, respectively). Conclusions The serum FGF-19 and β-klotho concentrations did not differ between the pregnancies with ICP and the healthy controls. However, in some cases, abnormalities in the FGF-19, β-klotho, and FGFR4 signaling system may play roles in the pathogenesis of ICP.Ahter Tanay TayyarAhmet TayyarSukran KozaliResul KarakusNadiye KorogluIlkbal Temel YukselGonca Yetkin YildirimIsmail DagMustafa ErogluTermedia Publishing Housearticlefgf-19beta-klothointrahepatic cholestasis of pregnancypathogenesiscyp7a1fibroblast growth factor-19β-klothoMedicineRENArchives of Medical Science, Vol 15, Iss 1, Pp 113-119 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	fgf-19 beta-klotho intrahepatic cholestasis of pregnancy pathogenesis cyp7a1 fibroblast growth factor-19 β-klotho Medicine R
spellingShingle	fgf-19 beta-klotho intrahepatic cholestasis of pregnancy pathogenesis cyp7a1 fibroblast growth factor-19 β-klotho Medicine R Ahter Tanay Tayyar Ahmet Tayyar Sukran Kozali Resul Karakus Nadiye Koroglu Ilkbal Temel Yuksel Gonca Yetkin Yildirim Ismail Dag Mustafa Eroglu Evaluation of FGF-19 and β-klotho as biomarkers in patients with intrahepatic cholestasis of pregnancy
description	Introduction Fibroblast growth factor-19 (FGF-19) and its co-receptor, beta-klotho, regulate bile acid synthesis in the liver as an enterohepatic feedback mechanism. In this study, our aim was to investigate the circulating FGF-19 and β-klotho levels in intrahepatic cholestasis of pregnancy (ICP) cases. Material and methods A cross-sectional study including 40 women whose pregnancies were complicated with ICP were recruited for the study group. Forty randomly selected healthy pregnant women comprised the control group. The patient characteristics, including maternal age, gravidity, parity, gestational age at the time of diagnosis, body mass index (BMI), and obstetric history, were recorded. The serum FGF-19 and β-klotho concentrations were measured using an enzyme-linked immunosorbent assay. Results Maternal age, gravidity, parity, body mass index at assessment, and gestational age at blood sampling were similar between the two groups (p > 0.05). Moreover, there were no significant differences in the FGF-19 and β-klotho concentrations between the two groups (p = 0.341 and p = 0.086, respectively). A positive correlation was detected between the β-klotho and FGF-19 levels, as well as between the FGF-19 level and BMI (r = 0.368, p = 0.020 and r = 0.389, p = 0.013, respectively). Conclusions The serum FGF-19 and β-klotho concentrations did not differ between the pregnancies with ICP and the healthy controls. However, in some cases, abnormalities in the FGF-19, β-klotho, and FGFR4 signaling system may play roles in the pathogenesis of ICP.
format	article
author	Ahter Tanay Tayyar Ahmet Tayyar Sukran Kozali Resul Karakus Nadiye Koroglu Ilkbal Temel Yuksel Gonca Yetkin Yildirim Ismail Dag Mustafa Eroglu
author_facet	Ahter Tanay Tayyar Ahmet Tayyar Sukran Kozali Resul Karakus Nadiye Koroglu Ilkbal Temel Yuksel Gonca Yetkin Yildirim Ismail Dag Mustafa Eroglu
author_sort	Ahter Tanay Tayyar
title	Evaluation of FGF-19 and β-klotho as biomarkers in patients with intrahepatic cholestasis of pregnancy
title_short	Evaluation of FGF-19 and β-klotho as biomarkers in patients with intrahepatic cholestasis of pregnancy
title_full	Evaluation of FGF-19 and β-klotho as biomarkers in patients with intrahepatic cholestasis of pregnancy
title_fullStr	Evaluation of FGF-19 and β-klotho as biomarkers in patients with intrahepatic cholestasis of pregnancy
title_full_unstemmed	Evaluation of FGF-19 and β-klotho as biomarkers in patients with intrahepatic cholestasis of pregnancy
title_sort	evaluation of fgf-19 and β-klotho as biomarkers in patients with intrahepatic cholestasis of pregnancy
publisher	Termedia Publishing House
publishDate	2018
url	https://doaj.org/article/74fe58c0417943409befd84ce5273909
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Evaluation of FGF-19 and β-klotho as biomarkers in patients with intrahepatic cholestasis of pregnancy

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