A robust and efficient method for Mendelian randomization with hundreds of genetic variants

Mendelian randomization (MR) is a method for inferring causal relationships between risk factors and outcomes via associated genetic variants. Here, Burgess et al. develop the contamination mixture method which yields robust MR results in the presence of invalid instrumental variables and groups var...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Stephen Burgess, Christopher N Foley, Elias Allara, James R Staley, Joanna M. M. Howson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/74ff71ea549c46d682697de209ffda29
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:74ff71ea549c46d682697de209ffda29
record_format	dspace
spelling	oai:doaj.org-article:74ff71ea549c46d682697de209ffda292021-12-02T15:39:15ZA robust and efficient method for Mendelian randomization with hundreds of genetic variants10.1038/s41467-019-14156-42041-1723https://doaj.org/article/74ff71ea549c46d682697de209ffda292020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14156-4https://doaj.org/toc/2041-1723Mendelian randomization (MR) is a method for inferring causal relationships between risk factors and outcomes via associated genetic variants. Here, Burgess et al. develop the contamination mixture method which yields robust MR results in the presence of invalid instrumental variables and groups variants by their effect estimates.Stephen BurgessChristopher N FoleyElias AllaraJames R StaleyJoanna M. M. HowsonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephen Burgess Christopher N Foley Elias Allara James R Staley Joanna M. M. Howson A robust and efficient method for Mendelian randomization with hundreds of genetic variants
description	Mendelian randomization (MR) is a method for inferring causal relationships between risk factors and outcomes via associated genetic variants. Here, Burgess et al. develop the contamination mixture method which yields robust MR results in the presence of invalid instrumental variables and groups variants by their effect estimates.
format	article
author	Stephen Burgess Christopher N Foley Elias Allara James R Staley Joanna M. M. Howson
author_facet	Stephen Burgess Christopher N Foley Elias Allara James R Staley Joanna M. M. Howson
author_sort	Stephen Burgess
title	A robust and efficient method for Mendelian randomization with hundreds of genetic variants
title_short	A robust and efficient method for Mendelian randomization with hundreds of genetic variants
title_full	A robust and efficient method for Mendelian randomization with hundreds of genetic variants
title_fullStr	A robust and efficient method for Mendelian randomization with hundreds of genetic variants
title_full_unstemmed	A robust and efficient method for Mendelian randomization with hundreds of genetic variants
title_sort	robust and efficient method for mendelian randomization with hundreds of genetic variants
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/74ff71ea549c46d682697de209ffda29
work_keys_str_mv	AT stephenburgess arobustandefficientmethodformendelianrandomizationwithhundredsofgeneticvariants AT christophernfoley arobustandefficientmethodformendelianrandomizationwithhundredsofgeneticvariants AT eliasallara arobustandefficientmethodformendelianrandomizationwithhundredsofgeneticvariants AT jamesrstaley arobustandefficientmethodformendelianrandomizationwithhundredsofgeneticvariants AT joannammhowson arobustandefficientmethodformendelianrandomizationwithhundredsofgeneticvariants AT stephenburgess robustandefficientmethodformendelianrandomizationwithhundredsofgeneticvariants AT christophernfoley robustandefficientmethodformendelianrandomizationwithhundredsofgeneticvariants AT eliasallara robustandefficientmethodformendelianrandomizationwithhundredsofgeneticvariants AT jamesrstaley robustandefficientmethodformendelianrandomizationwithhundredsofgeneticvariants AT joannammhowson robustandefficientmethodformendelianrandomizationwithhundredsofgeneticvariants
_version_	1718385940975583232

A robust and efficient method for Mendelian randomization with hundreds of genetic variants

Ejemplares similares