A robust and efficient method for Mendelian randomization with hundreds of genetic variants

A robust and efficient method for Mendelian randomization with hundreds of genetic variants

Mendelian randomization (MR) is a method for inferring causal relationships between risk factors and outcomes via associated genetic variants. Here, Burgess et al. develop the contamination mixture method which yields robust MR results in the presence of invalid instrumental variables and groups var...

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Autores principales: Stephen Burgess, Christopher N Foley, Elias Allara, James R Staley, Joanna M. M. Howson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/74ff71ea549c46d682697de209ffda29
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