Carbon nanotubes as cancer therapeutic carriers and mediators

Kuk Hui Son,1 Jeong Hee Hong,2 Jin Woo Lee3 1Department of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Center, 2Department of Physiology, 3Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, Republic of Korea Abstract: Carbon nanotubes (CNTs) ha...

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Autores principales:	Son KH, Hong JH, Lee JW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Carbon nanotubes (CNTs) Cancer Therapy Carrier Mediator Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/75069c195d374b77a7f68cee7c3525a7
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spelling	oai:doaj.org-article:75069c195d374b77a7f68cee7c3525a72021-12-02T00:37:18ZCarbon nanotubes as cancer therapeutic carriers and mediators1178-2013https://doaj.org/article/75069c195d374b77a7f68cee7c3525a72016-10-01T00:00:00Zhttps://www.dovepress.com/carbon-nanotubes-as-cancer-therapeutic-carriers-and-mediators-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Kuk Hui Son,1 Jeong Hee Hong,2 Jin Woo Lee3 1Department of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Center, 2Department of Physiology, 3Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, Republic of Korea Abstract: Carbon nanotubes (CNTs) have received increasing attention in biomedical fields because of their unique structures and properties, including high aspect ratios, large surface areas, rich surface chemical functionalities, and size stability on the nanoscale. Particularly, they are attractive as carriers and mediators for cancer therapy. Through appropriate functionalization, CNTs have been used as nanocarriers for anticancer drugs including doxorubicin, camptothecin, carboplatin, cisplatin, paclitaxel, Pt(II), and Pt(IV), and genes including plasmid DNA, small-interfering RNA, oligonucleotides, and RNA/DNA aptamers. CNTs can also deliver proteins and immunotherapy components. Using combinations of light energy, they have also been applied as mediators for photothermal therapy and photodynamic therapy to directly destroy cancer cells without severely damaging normal tissue. If limitations such as a long-term cytotoxicity in the body, lack of size uniformity during the synthetic process, loading deviations for drug–CNT complexes, and release controllability at the target point are overcome, CNTs will become one of the strongest tools that are available for various other biomedical fields as well as for cancer therapy. Keywords: carbon nanotubes, cancer, therapy, carrier, mediatorSon KHHong JHLee JWDove Medical PressarticleCarbon nanotubes (CNTs)CancerTherapyCarrierMediatorMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 5163-5185 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Carbon nanotubes (CNTs) Cancer Therapy Carrier Mediator Medicine (General) R5-920
spellingShingle	Carbon nanotubes (CNTs) Cancer Therapy Carrier Mediator Medicine (General) R5-920 Son KH Hong JH Lee JW Carbon nanotubes as cancer therapeutic carriers and mediators
description	Kuk Hui Son,1 Jeong Hee Hong,2 Jin Woo Lee3 1Department of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Center, 2Department of Physiology, 3Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, Republic of Korea Abstract: Carbon nanotubes (CNTs) have received increasing attention in biomedical fields because of their unique structures and properties, including high aspect ratios, large surface areas, rich surface chemical functionalities, and size stability on the nanoscale. Particularly, they are attractive as carriers and mediators for cancer therapy. Through appropriate functionalization, CNTs have been used as nanocarriers for anticancer drugs including doxorubicin, camptothecin, carboplatin, cisplatin, paclitaxel, Pt(II), and Pt(IV), and genes including plasmid DNA, small-interfering RNA, oligonucleotides, and RNA/DNA aptamers. CNTs can also deliver proteins and immunotherapy components. Using combinations of light energy, they have also been applied as mediators for photothermal therapy and photodynamic therapy to directly destroy cancer cells without severely damaging normal tissue. If limitations such as a long-term cytotoxicity in the body, lack of size uniformity during the synthetic process, loading deviations for drug–CNT complexes, and release controllability at the target point are overcome, CNTs will become one of the strongest tools that are available for various other biomedical fields as well as for cancer therapy. Keywords: carbon nanotubes, cancer, therapy, carrier, mediator
format	article
author	Son KH Hong JH Lee JW
author_facet	Son KH Hong JH Lee JW
author_sort	Son KH
title	Carbon nanotubes as cancer therapeutic carriers and mediators
title_short	Carbon nanotubes as cancer therapeutic carriers and mediators
title_full	Carbon nanotubes as cancer therapeutic carriers and mediators
title_fullStr	Carbon nanotubes as cancer therapeutic carriers and mediators
title_full_unstemmed	Carbon nanotubes as cancer therapeutic carriers and mediators
title_sort	carbon nanotubes as cancer therapeutic carriers and mediators
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/75069c195d374b77a7f68cee7c3525a7
work_keys_str_mv	AT sonkh carbonnanotubesascancertherapeuticcarriersandmediators AT hongjh carbonnanotubesascancertherapeuticcarriersandmediators AT leejw carbonnanotubesascancertherapeuticcarriersandmediators
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Carbon nanotubes as cancer therapeutic carriers and mediators

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