Clinical, Electrophysiological and Radiological Features of Nitrous Oxide-Induced Neurological Disorders

Lei Bao,* Qing Li,* Qingjie Li, Hao Chen, Ruixue Zhang, Hongjuan Shi, Guiyun Cui Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lei BaoDepartment...

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Autores principales:	Bao L, Li Q, Chen H, Zhang R, Shi H, Cui G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	nitrous oxide neurological disorders subacute combined degeneration neuropathy vitamin b12 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/7508794f95cb431e8cd12414ef5d0fbf
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spelling	oai:doaj.org-article:7508794f95cb431e8cd12414ef5d0fbf2021-12-02T09:39:17ZClinical, Electrophysiological and Radiological Features of Nitrous Oxide-Induced Neurological Disorders1178-2021https://doaj.org/article/7508794f95cb431e8cd12414ef5d0fbf2020-04-01T00:00:00Zhttps://www.dovepress.com/clinical-electrophysiological-and-radiological-features-of-nitrous-oxi-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Lei Bao,* Qing Li,* Qingjie Li, Hao Chen, Ruixue Zhang, Hongjuan Shi, Guiyun Cui Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lei BaoDepartment of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221004, People’s Republic of ChinaTel/Fax +86 516 85802129Email baolei56@gmail.comPurpose: We summarized the clinical manifestations, laboratory and electrodiagnostic characteristics and magnetic resonance imaging (MRI) findings of nitrous oxide (N2O) abuse-induced neurological disorders.Patients and Methods: We retrospectively reviewed 33 patients with N2O abuse-induced neurological disorders and reported their demographic data, clinical manifestations, laboratory examinations, nerve conduction studies, together with spinal and brain MRI.Results: The most frequent clinical manifestations included numbness and weakness in the extremities and unspecified gait disturbance. Low serum vitamin B12 levels were found in 9 patients, and high homocysteine levels were noted in 27 patients. Nerve conduction studies showed a sensory-motor neuropathy. Sixteen patients showed bilateral high-intensity T2 signal within the posterior column on spinal MRI, and four patients showed cerebral white matter lesions on brain MRI.Conclusion: N2O abuse has become a significant public health problem because of the severe neurological disorders related to chronic abuse. Clinical physicians should be aware of the toxic effects of N2O.Keywords: nitrous oxide, neurological disorders, subacute combined degeneration, neuropathy, vitamin B12Bao LLi QLi QChen HZhang RShi HCui GDove Medical Pressarticlenitrous oxideneurological disorderssubacute combined degenerationneuropathyvitamin b12Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 977-984 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	nitrous oxide neurological disorders subacute combined degeneration neuropathy vitamin b12 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	nitrous oxide neurological disorders subacute combined degeneration neuropathy vitamin b12 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Bao L Li Q Li Q Chen H Zhang R Shi H Cui G Clinical, Electrophysiological and Radiological Features of Nitrous Oxide-Induced Neurological Disorders
description	Lei Bao,* Qing Li,* Qingjie Li, Hao Chen, Ruixue Zhang, Hongjuan Shi, Guiyun Cui Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lei BaoDepartment of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221004, People’s Republic of ChinaTel/Fax +86 516 85802129Email baolei56@gmail.comPurpose: We summarized the clinical manifestations, laboratory and electrodiagnostic characteristics and magnetic resonance imaging (MRI) findings of nitrous oxide (N2O) abuse-induced neurological disorders.Patients and Methods: We retrospectively reviewed 33 patients with N2O abuse-induced neurological disorders and reported their demographic data, clinical manifestations, laboratory examinations, nerve conduction studies, together with spinal and brain MRI.Results: The most frequent clinical manifestations included numbness and weakness in the extremities and unspecified gait disturbance. Low serum vitamin B12 levels were found in 9 patients, and high homocysteine levels were noted in 27 patients. Nerve conduction studies showed a sensory-motor neuropathy. Sixteen patients showed bilateral high-intensity T2 signal within the posterior column on spinal MRI, and four patients showed cerebral white matter lesions on brain MRI.Conclusion: N2O abuse has become a significant public health problem because of the severe neurological disorders related to chronic abuse. Clinical physicians should be aware of the toxic effects of N2O.Keywords: nitrous oxide, neurological disorders, subacute combined degeneration, neuropathy, vitamin B12
format	article
author	Bao L Li Q Li Q Chen H Zhang R Shi H Cui G
author_facet	Bao L Li Q Li Q Chen H Zhang R Shi H Cui G
author_sort	Bao L
title	Clinical, Electrophysiological and Radiological Features of Nitrous Oxide-Induced Neurological Disorders
title_short	Clinical, Electrophysiological and Radiological Features of Nitrous Oxide-Induced Neurological Disorders
title_full	Clinical, Electrophysiological and Radiological Features of Nitrous Oxide-Induced Neurological Disorders
title_fullStr	Clinical, Electrophysiological and Radiological Features of Nitrous Oxide-Induced Neurological Disorders
title_full_unstemmed	Clinical, Electrophysiological and Radiological Features of Nitrous Oxide-Induced Neurological Disorders
title_sort	clinical, electrophysiological and radiological features of nitrous oxide-induced neurological disorders
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/7508794f95cb431e8cd12414ef5d0fbf
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Clinical, Electrophysiological and Radiological Features of Nitrous Oxide-Induced Neurological Disorders

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