Investigation into the presence of and serological response to XMRV in CFS patients.

The novel human gammaretrovirus xenotropic murine leukemia virus-related virus (XMRV), originally described in prostate cancer, has also been implicated in chronic fatigue syndrome (CFS). When later reports failed to confirm the link to CFS, they were often criticised for not using the conditions de...

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Autores principales:	Otto Erlwein, Mark J Robinson, Steve Kaye, Gillian Wills, Shozo Izui, Simon Wessely, Jonathan Weber, Anthony Cleare, David Collier, Myra O McClure
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7509145a233746fc83c81e1ee8d96881
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spelling	oai:doaj.org-article:7509145a233746fc83c81e1ee8d968812021-11-18T06:57:31ZInvestigation into the presence of and serological response to XMRV in CFS patients.1932-620310.1371/journal.pone.0017592https://doaj.org/article/7509145a233746fc83c81e1ee8d968812011-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21408077/?tool=EBIhttps://doaj.org/toc/1932-6203The novel human gammaretrovirus xenotropic murine leukemia virus-related virus (XMRV), originally described in prostate cancer, has also been implicated in chronic fatigue syndrome (CFS). When later reports failed to confirm the link to CFS, they were often criticised for not using the conditions described in the original study. Here, we revisit our patient cohort to investigate the XMRV status in those patients by means of the original PCR protocol which linked the virus to CFS. In addition, sera from our CFS patients were assayed for the presence of xenotropic virus envelope protein, as well as a serological response to it. The results further strengthen our contention that there is no evidence for an association of XMRV with CFS, at least in the UK.Otto ErlweinMark J RobinsonSteve KayeGillian WillsShozo IzuiSimon WesselyJonathan WeberAnthony CleareDavid CollierMyra O McClurePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 3, p e17592 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Otto Erlwein Mark J Robinson Steve Kaye Gillian Wills Shozo Izui Simon Wessely Jonathan Weber Anthony Cleare David Collier Myra O McClure Investigation into the presence of and serological response to XMRV in CFS patients.
description	The novel human gammaretrovirus xenotropic murine leukemia virus-related virus (XMRV), originally described in prostate cancer, has also been implicated in chronic fatigue syndrome (CFS). When later reports failed to confirm the link to CFS, they were often criticised for not using the conditions described in the original study. Here, we revisit our patient cohort to investigate the XMRV status in those patients by means of the original PCR protocol which linked the virus to CFS. In addition, sera from our CFS patients were assayed for the presence of xenotropic virus envelope protein, as well as a serological response to it. The results further strengthen our contention that there is no evidence for an association of XMRV with CFS, at least in the UK.
format	article
author	Otto Erlwein Mark J Robinson Steve Kaye Gillian Wills Shozo Izui Simon Wessely Jonathan Weber Anthony Cleare David Collier Myra O McClure
author_facet	Otto Erlwein Mark J Robinson Steve Kaye Gillian Wills Shozo Izui Simon Wessely Jonathan Weber Anthony Cleare David Collier Myra O McClure
author_sort	Otto Erlwein
title	Investigation into the presence of and serological response to XMRV in CFS patients.
title_short	Investigation into the presence of and serological response to XMRV in CFS patients.
title_full	Investigation into the presence of and serological response to XMRV in CFS patients.
title_fullStr	Investigation into the presence of and serological response to XMRV in CFS patients.
title_full_unstemmed	Investigation into the presence of and serological response to XMRV in CFS patients.
title_sort	investigation into the presence of and serological response to xmrv in cfs patients.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/7509145a233746fc83c81e1ee8d96881
work_keys_str_mv	AT ottoerlwein investigationintothepresenceofandserologicalresponsetoxmrvincfspatients AT markjrobinson investigationintothepresenceofandserologicalresponsetoxmrvincfspatients AT stevekaye investigationintothepresenceofandserologicalresponsetoxmrvincfspatients AT gillianwills investigationintothepresenceofandserologicalresponsetoxmrvincfspatients AT shozoizui investigationintothepresenceofandserologicalresponsetoxmrvincfspatients AT simonwessely investigationintothepresenceofandserologicalresponsetoxmrvincfspatients AT jonathanweber investigationintothepresenceofandserologicalresponsetoxmrvincfspatients AT anthonycleare investigationintothepresenceofandserologicalresponsetoxmrvincfspatients AT davidcollier investigationintothepresenceofandserologicalresponsetoxmrvincfspatients AT myraomcclure investigationintothepresenceofandserologicalresponsetoxmrvincfspatients
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Investigation into the presence of and serological response to XMRV in CFS patients.

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