CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells

Clark et al. explore the ability of ligands to activate the calcitonin-like receptor (CLR) in primary endothelial cells, and the influence of co-expressed receptor-activity modifying proteins (RAMPs). Their study reveals that GPCR agonist bias occurs naturally in human cells and plays a fundamental...

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Autores principales:	Ashley J. Clark, Niamh Mullooly, Dewi Safitri, Matthew Harris, Tessa de Vries, Antoinette MaassenVanDenBrink, David R. Poyner, Davide Gianni, Mark Wigglesworth, Graham Ladds
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/750a5c1d0a384cd190361d11fbf63d68
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:750a5c1d0a384cd190361d11fbf63d682021-12-02T17:14:23ZCGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells10.1038/s42003-021-02293-w2399-3642https://doaj.org/article/750a5c1d0a384cd190361d11fbf63d682021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02293-whttps://doaj.org/toc/2399-3642Clark et al. explore the ability of ligands to activate the calcitonin-like receptor (CLR) in primary endothelial cells, and the influence of co-expressed receptor-activity modifying proteins (RAMPs). Their study reveals that GPCR agonist bias occurs naturally in human cells and plays a fundamental role in providing unique functions to endogenous agonists.Ashley J. ClarkNiamh MulloolyDewi SafitriMatthew HarrisTessa de VriesAntoinette MaassenVanDenBrinkDavid R. PoynerDavide GianniMark WigglesworthGraham LaddsNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Ashley J. Clark Niamh Mullooly Dewi Safitri Matthew Harris Tessa de Vries Antoinette MaassenVanDenBrink David R. Poyner Davide Gianni Mark Wigglesworth Graham Ladds CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells
description	Clark et al. explore the ability of ligands to activate the calcitonin-like receptor (CLR) in primary endothelial cells, and the influence of co-expressed receptor-activity modifying proteins (RAMPs). Their study reveals that GPCR agonist bias occurs naturally in human cells and plays a fundamental role in providing unique functions to endogenous agonists.
format	article
author	Ashley J. Clark Niamh Mullooly Dewi Safitri Matthew Harris Tessa de Vries Antoinette MaassenVanDenBrink David R. Poyner Davide Gianni Mark Wigglesworth Graham Ladds
author_facet	Ashley J. Clark Niamh Mullooly Dewi Safitri Matthew Harris Tessa de Vries Antoinette MaassenVanDenBrink David R. Poyner Davide Gianni Mark Wigglesworth Graham Ladds
author_sort	Ashley J. Clark
title	CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells
title_short	CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells
title_full	CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells
title_fullStr	CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells
title_full_unstemmed	CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells
title_sort	cgrp, adrenomedullin and adrenomedullin 2 display endogenous gpcr agonist bias in primary human cardiovascular cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/750a5c1d0a384cd190361d11fbf63d68
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CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells

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