CERVICAL NEOPLASIA AND VIRUS LOAD OF HPV 16 GENOTYPE

Abstract. The 83 biopsies from HPV16-positive cervical epithelial neoplasies were studied by cytological, histological, immunomorphological methods and PCR. At cervical ectopia virus loading changed from 2.49 up to 6.65 lg copies of DNA HPV/105. At CIN II and CIN III the quantity of a virus exceeded...

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Autores principales:	V. S. Chirsky, V. A. Ershov, A. A. Vyazovaya, O. V. Narvskaya, L. V. Lyalina
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	hpv viral load cervix uteri cin cancer perimeter of nucleus Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/750bfeeafc5a4bd3a657f101cb542f42
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spelling	oai:doaj.org-article:750bfeeafc5a4bd3a657f101cb542f422021-11-22T07:09:46ZCERVICAL NEOPLASIA AND VIRUS LOAD OF HPV 16 GENOTYPE2220-76192313-739810.15789/2220-7619-2014-2-192-196https://doaj.org/article/750bfeeafc5a4bd3a657f101cb542f422014-07-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/172https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. The 83 biopsies from HPV16-positive cervical epithelial neoplasies were studied by cytological, histological, immunomorphological methods and PCR. At cervical ectopia virus loading changed from 2.49 up to 6.65 lg copies of DNA HPV/105. At CIN II and CIN III the quantity of a virus exceeded 4 lg copies of DNA HPV/105 of cells, at the CIN I, Ca in situ and SCC — 5 lg copies of DNA HPV/105 of cells. At progressing of neoplasia frequency of revealing of clinically significant parameters of virus loading correlated with increase in average values of nuclear perimeter of cells, associated with HPV. At ectopia and LSIL expression of capsid protein L1 testified about virus production. At HSIL and SCC at absence expression L1 HPV high parameters of virus load testified to infringement of life cycle papillomaviruses.V. S. ChirskyV. A. ErshovA. A. VyazovayaO. V. NarvskayaL. V. LyalinaSankt-Peterburg : NIIÈM imeni Pasteraarticlehpvviral loadcervix utericincancerperimeter of nucleusInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 4, Iss 2, Pp 192-196 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	hpv viral load cervix uteri cin cancer perimeter of nucleus Infectious and parasitic diseases RC109-216
spellingShingle	hpv viral load cervix uteri cin cancer perimeter of nucleus Infectious and parasitic diseases RC109-216 V. S. Chirsky V. A. Ershov A. A. Vyazovaya O. V. Narvskaya L. V. Lyalina CERVICAL NEOPLASIA AND VIRUS LOAD OF HPV 16 GENOTYPE
description	Abstract. The 83 biopsies from HPV16-positive cervical epithelial neoplasies were studied by cytological, histological, immunomorphological methods and PCR. At cervical ectopia virus loading changed from 2.49 up to 6.65 lg copies of DNA HPV/105. At CIN II and CIN III the quantity of a virus exceeded 4 lg copies of DNA HPV/105 of cells, at the CIN I, Ca in situ and SCC — 5 lg copies of DNA HPV/105 of cells. At progressing of neoplasia frequency of revealing of clinically significant parameters of virus loading correlated with increase in average values of nuclear perimeter of cells, associated with HPV. At ectopia and LSIL expression of capsid protein L1 testified about virus production. At HSIL and SCC at absence expression L1 HPV high parameters of virus load testified to infringement of life cycle papillomaviruses.
format	article
author	V. S. Chirsky V. A. Ershov A. A. Vyazovaya O. V. Narvskaya L. V. Lyalina
author_facet	V. S. Chirsky V. A. Ershov A. A. Vyazovaya O. V. Narvskaya L. V. Lyalina
author_sort	V. S. Chirsky
title	CERVICAL NEOPLASIA AND VIRUS LOAD OF HPV 16 GENOTYPE
title_short	CERVICAL NEOPLASIA AND VIRUS LOAD OF HPV 16 GENOTYPE
title_full	CERVICAL NEOPLASIA AND VIRUS LOAD OF HPV 16 GENOTYPE
title_fullStr	CERVICAL NEOPLASIA AND VIRUS LOAD OF HPV 16 GENOTYPE
title_full_unstemmed	CERVICAL NEOPLASIA AND VIRUS LOAD OF HPV 16 GENOTYPE
title_sort	cervical neoplasia and virus load of hpv 16 genotype
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/750bfeeafc5a4bd3a657f101cb542f42
work_keys_str_mv	AT vschirsky cervicalneoplasiaandvirusloadofhpv16genotype AT vaershov cervicalneoplasiaandvirusloadofhpv16genotype AT aavyazovaya cervicalneoplasiaandvirusloadofhpv16genotype AT ovnarvskaya cervicalneoplasiaandvirusloadofhpv16genotype AT lvlyalina cervicalneoplasiaandvirusloadofhpv16genotype
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CERVICAL NEOPLASIA AND VIRUS LOAD OF HPV 16 GENOTYPE

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