A widespread alternate form of cap-dependent mRNA translation initiation

Binding of eIF4E to the 5′ cap of mRNAs is a key early step in canonical translation initiation, but the requirement for eIF4E is not universal. Here the authors show that the eIF4G homolog DAP5 interacts with eIF3 to promote cap-dependent translation of a significant number of mRNA in an eIF4E-inde...

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Autores principales:	Columba de la Parra, Amanda Ernlund, Amandine Alard, Kelly Ruggles, Beatrix Ueberheide, Robert J. Schneider
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/750fa7f27de34646a8ea452e76018a5c
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spelling	oai:doaj.org-article:750fa7f27de34646a8ea452e76018a5c2021-12-02T16:49:18ZA widespread alternate form of cap-dependent mRNA translation initiation10.1038/s41467-018-05539-02041-1723https://doaj.org/article/750fa7f27de34646a8ea452e76018a5c2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05539-0https://doaj.org/toc/2041-1723Binding of eIF4E to the 5′ cap of mRNAs is a key early step in canonical translation initiation, but the requirement for eIF4E is not universal. Here the authors show that the eIF4G homolog DAP5 interacts with eIF3 to promote cap-dependent translation of a significant number of mRNA in an eIF4E-independent manner.Columba de la ParraAmanda ErnlundAmandine AlardKelly RugglesBeatrix UeberheideRobert J. SchneiderNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Columba de la Parra Amanda Ernlund Amandine Alard Kelly Ruggles Beatrix Ueberheide Robert J. Schneider A widespread alternate form of cap-dependent mRNA translation initiation
description	Binding of eIF4E to the 5′ cap of mRNAs is a key early step in canonical translation initiation, but the requirement for eIF4E is not universal. Here the authors show that the eIF4G homolog DAP5 interacts with eIF3 to promote cap-dependent translation of a significant number of mRNA in an eIF4E-independent manner.
format	article
author	Columba de la Parra Amanda Ernlund Amandine Alard Kelly Ruggles Beatrix Ueberheide Robert J. Schneider
author_facet	Columba de la Parra Amanda Ernlund Amandine Alard Kelly Ruggles Beatrix Ueberheide Robert J. Schneider
author_sort	Columba de la Parra
title	A widespread alternate form of cap-dependent mRNA translation initiation
title_short	A widespread alternate form of cap-dependent mRNA translation initiation
title_full	A widespread alternate form of cap-dependent mRNA translation initiation
title_fullStr	A widespread alternate form of cap-dependent mRNA translation initiation
title_full_unstemmed	A widespread alternate form of cap-dependent mRNA translation initiation
title_sort	widespread alternate form of cap-dependent mrna translation initiation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/750fa7f27de34646a8ea452e76018a5c
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A widespread alternate form of cap-dependent mRNA translation initiation

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