Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia

Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a gestational disease caused by maternal immune responses against fetal platelets. Using a FNAIT mouse model and human trophoblast cell lines, here the authors show that uterine natural killer cell-mediated trophoblast apoptosis contributes to FN...

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Autores principales:	Issaka Yougbaré, Wei-She Tai, Darko Zdravic, Brigitta Elaine Oswald, Sean Lang, Guangheng Zhu, Howard Leong-Poi, Dawei Qu, Lisa Yu, Caroline Dunk, Jianhong Zhang, John G. Sled, Stephen J. Lye, Jelena Brkić, Chun Peng, Petter Höglund, B. Anne Croy, S. Lee Adamson, Xiao-Yan Wen, Duncan J. Stewart, John Freedman, Heyu Ni
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7510b05885154c00ab69cd14d56278e4
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spelling	oai:doaj.org-article:7510b05885154c00ab69cd14d56278e42021-12-02T10:47:59ZActivated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia10.1038/s41467-017-00269-12041-1723https://doaj.org/article/7510b05885154c00ab69cd14d56278e42017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00269-1https://doaj.org/toc/2041-1723Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a gestational disease caused by maternal immune responses against fetal platelets. Using a FNAIT mouse model and human trophoblast cell lines, here the authors show that uterine natural killer cell-mediated trophoblast apoptosis contributes to FNAIT pathogenesis.Issaka YougbaréWei-She TaiDarko ZdravicBrigitta Elaine OswaldSean LangGuangheng ZhuHoward Leong-PoiDawei QuLisa YuCaroline DunkJianhong ZhangJohn G. SledStephen J. LyeJelena BrkićChun PengPetter HöglundB. Anne CroyS. Lee AdamsonXiao-Yan WenDuncan J. StewartJohn FreedmanHeyu NiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Issaka Yougbaré Wei-She Tai Darko Zdravic Brigitta Elaine Oswald Sean Lang Guangheng Zhu Howard Leong-Poi Dawei Qu Lisa Yu Caroline Dunk Jianhong Zhang John G. Sled Stephen J. Lye Jelena Brkić Chun Peng Petter Höglund B. Anne Croy S. Lee Adamson Xiao-Yan Wen Duncan J. Stewart John Freedman Heyu Ni Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia
description	Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a gestational disease caused by maternal immune responses against fetal platelets. Using a FNAIT mouse model and human trophoblast cell lines, here the authors show that uterine natural killer cell-mediated trophoblast apoptosis contributes to FNAIT pathogenesis.
format	article
author	Issaka Yougbaré Wei-She Tai Darko Zdravic Brigitta Elaine Oswald Sean Lang Guangheng Zhu Howard Leong-Poi Dawei Qu Lisa Yu Caroline Dunk Jianhong Zhang John G. Sled Stephen J. Lye Jelena Brkić Chun Peng Petter Höglund B. Anne Croy S. Lee Adamson Xiao-Yan Wen Duncan J. Stewart John Freedman Heyu Ni
author_facet	Issaka Yougbaré Wei-She Tai Darko Zdravic Brigitta Elaine Oswald Sean Lang Guangheng Zhu Howard Leong-Poi Dawei Qu Lisa Yu Caroline Dunk Jianhong Zhang John G. Sled Stephen J. Lye Jelena Brkić Chun Peng Petter Höglund B. Anne Croy S. Lee Adamson Xiao-Yan Wen Duncan J. Stewart John Freedman Heyu Ni
author_sort	Issaka Yougbaré
title	Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia
title_short	Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia
title_full	Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia
title_fullStr	Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia
title_full_unstemmed	Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia
title_sort	activated nk cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7510b05885154c00ab69cd14d56278e4
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Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia

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