Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases

The IL-36 family of cytokines were identified in the early 2000’s as a new subfamily of the IL-1 cytokine family, and since then, the role of IL-36 cytokines during various inflammatory processes has been characterized. While most of the research has focused on the role of these cytokines in autoimm...

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Autores principales:	Hernán F. Peñaloza, Rick van der Geest, Joel A. Ybe, Theodore J. Standiford, Janet S. Lee
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	interleukin-36 cytokines IL-1Rrp2 host/microbe proteases inflammatory response amplification lung infectious diseases lung inflammation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/7515a4e4023b479f9acd42feaa6c8494
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spelling	oai:doaj.org-article:7515a4e4023b479f9acd42feaa6c84942021-11-30T14:00:33ZInterleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases1664-322410.3389/fimmu.2021.754702https://doaj.org/article/7515a4e4023b479f9acd42feaa6c84942021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.754702/fullhttps://doaj.org/toc/1664-3224The IL-36 family of cytokines were identified in the early 2000’s as a new subfamily of the IL-1 cytokine family, and since then, the role of IL-36 cytokines during various inflammatory processes has been characterized. While most of the research has focused on the role of these cytokines in autoimmune skin diseases such as psoriasis and dermatitis, recent studies have also shown the importance of IL-36 cytokines in the lung inflammatory response during infectious and non-infectious diseases. In this review, we discuss the biology of IL-36 cytokines in terms of how they are produced and activated, as well as their effects on myeloid and lymphoid cells during inflammation. We also discuss the role of these cytokines during lung infectious diseases caused by bacteria and influenza virus, as well as other inflammatory conditions in the lungs such as allergic asthma, lung fibrosis, chronic obstructive pulmonary disease, cystic fibrosis and cancer. Finally, we discuss the current therapeutic advances that target the IL-36 pathway and the possibility to extend these tools to treat lung inflammatory diseases.Hernán F. PeñalozaRick van der GeestJoel A. YbeTheodore J. StandifordJanet S. LeeJanet S. LeeFrontiers Media S.A.articleinterleukin-36 cytokinesIL-1Rrp2host/microbe proteasesinflammatory response amplificationlung infectious diseaseslung inflammationImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	interleukin-36 cytokines IL-1Rrp2 host/microbe proteases inflammatory response amplification lung infectious diseases lung inflammation Immunologic diseases. Allergy RC581-607
spellingShingle	interleukin-36 cytokines IL-1Rrp2 host/microbe proteases inflammatory response amplification lung infectious diseases lung inflammation Immunologic diseases. Allergy RC581-607 Hernán F. Peñaloza Rick van der Geest Joel A. Ybe Theodore J. Standiford Janet S. Lee Janet S. Lee Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases
description	The IL-36 family of cytokines were identified in the early 2000’s as a new subfamily of the IL-1 cytokine family, and since then, the role of IL-36 cytokines during various inflammatory processes has been characterized. While most of the research has focused on the role of these cytokines in autoimmune skin diseases such as psoriasis and dermatitis, recent studies have also shown the importance of IL-36 cytokines in the lung inflammatory response during infectious and non-infectious diseases. In this review, we discuss the biology of IL-36 cytokines in terms of how they are produced and activated, as well as their effects on myeloid and lymphoid cells during inflammation. We also discuss the role of these cytokines during lung infectious diseases caused by bacteria and influenza virus, as well as other inflammatory conditions in the lungs such as allergic asthma, lung fibrosis, chronic obstructive pulmonary disease, cystic fibrosis and cancer. Finally, we discuss the current therapeutic advances that target the IL-36 pathway and the possibility to extend these tools to treat lung inflammatory diseases.
format	article
author	Hernán F. Peñaloza Rick van der Geest Joel A. Ybe Theodore J. Standiford Janet S. Lee Janet S. Lee
author_facet	Hernán F. Peñaloza Rick van der Geest Joel A. Ybe Theodore J. Standiford Janet S. Lee Janet S. Lee
author_sort	Hernán F. Peñaloza
title	Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases
title_short	Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases
title_full	Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases
title_fullStr	Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases
title_full_unstemmed	Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases
title_sort	interleukin-36 cytokines in infectious and non-infectious lung diseases
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7515a4e4023b479f9acd42feaa6c8494
work_keys_str_mv	AT hernanfpenaloza interleukin36cytokinesininfectiousandnoninfectiouslungdiseases AT rickvandergeest interleukin36cytokinesininfectiousandnoninfectiouslungdiseases AT joelaybe interleukin36cytokinesininfectiousandnoninfectiouslungdiseases AT theodorejstandiford interleukin36cytokinesininfectiousandnoninfectiouslungdiseases AT janetslee interleukin36cytokinesininfectiousandnoninfectiouslungdiseases AT janetslee interleukin36cytokinesininfectiousandnoninfectiouslungdiseases
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Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases

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